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Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics.
Mims TS, Kumari R, Leathem C, Antunes K, Joseph S, Yen MI, Ferstl D, Jamieson SM, Sabbar A, Biebel C, Lazarevic N, Willis NB, Henry L, Yen CE, Smith JP, Gosain A, Meisel M, Willis KA, Talati AJ, Elabiad MT, Hibl B, Pierre JF. Mims TS, et al. Among authors: yen mi. Am J Physiol Gastrointest Liver Physiol. 2023 Dec 1;325(6):G556-G569. doi: 10.1152/ajpgi.00129.2023. Epub 2023 Sep 27. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37753583
We randomized mouse pups to PN or sham surgery controls +/- ABX exposure. ABX or short-term PN decreased liver and brain organ weights, intestinal length, and mucosal architecture (vs. controls). ...Within the gut, PN elevated the relative abundance of Akkermansia, Enteroc …
We randomized mouse pups to PN or sham surgery controls +/- ABX exposure. ABX or short-term PN decreased liver and brain organ weight …