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Deep-supercooling for extended preservation of adipose-derived stem cells.
Huang H, Rey-Bedón C, Yarmush ML, Usta OB. Huang H, et al. Among authors: yarmush ml. Cryobiology. 2020 Feb 1;92:67-75. doi: 10.1016/j.cryobiol.2019.11.004. Epub 2019 Nov 18. Cryobiology. 2020. PMID: 31751557 Free PMC article.
Traditional cryopreservation via slow-freezing or vitrification provides long-term storage but requires cytotoxic cryoprotectants (CPA) and tedious CPA loading/unloading, cooling, and recovering procedures. ...Enabled by surface sealing with an immiscible oil phase, cell s …
Traditional cryopreservation via slow-freezing or vitrification provides long-term storage but requires cytotoxic cryoprotectants (CP …
A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles.
Li L, Gokduman K, Gokaltun A, Yarmush ML, Usta OB. Li L, et al. Among authors: yarmush ml. Nanomedicine (Lond). 2019 Aug;14(16):2209-2226. doi: 10.2217/nnm-2019-0086. Epub 2019 Jun 10. Nanomedicine (Lond). 2019. PMID: 31179822 Free PMC article.
Methods: A microfluidic 3D hepatocyte chip with three material layers, which contains primary rat hepatocytes, has been fabricated and tested using different concentrations (50, 100 and 200 mug/ml) of SPION in 3-day (short-term) and 1-week (long-term) cultures. Resu …
Methods: A microfluidic 3D hepatocyte chip with three material layers, which contains primary rat hepatocytes, has been fabricated and teste …
Oxygenated UW Solution Decreases ATP Decay and Improves Survival After Transplantation of DCD Liver Grafts.
Martins PN, Berendsen TA, Yeh H, Bruinsma BG, Izamis ML, Op den Dries S, Gillooly AR, Porte R, Yarmush ML, Uygun K, Markmann JF. Martins PN, et al. Among authors: yarmush ml. Transplantation. 2019 Feb;103(2):363-370. doi: 10.1097/TP.0000000000002530. Transplantation. 2019. PMID: 30422952
Animals that received DCD grafts preserved in higher oxygenation solution showed improved survival: 4 out of 6 animals survived long-term whereas all control group animals died within 24 hours. CONCLUSIONS: The additional oxygen provided by PFC during static cold preservat …
Animals that received DCD grafts preserved in higher oxygenation solution showed improved survival: 4 out of 6 animals survived long-term …
Long-term deep-supercooling of large-volume water and red cell suspensions via surface sealing with immiscible liquids.
Huang H, Yarmush ML, Usta OB. Huang H, et al. Among authors: yarmush ml. Nat Commun. 2018 Aug 10;9(1):3201. doi: 10.1038/s41467-018-05636-0. Nat Commun. 2018. PMID: 30097570 Free PMC article.
Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume (> 1 ml), and low temperatures (< -10 C) supercooling of aqueous solutions. ...
Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volu …
Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain.
Devalliere J, Chen Y, Dooley K, Yarmush ML, Uygun BE. Devalliere J, et al. Among authors: yarmush ml. Acta Biomater. 2018 Sep 15;78:151-164. doi: 10.1016/j.actbio.2018.07.046. Epub 2018 Jul 31. Acta Biomater. 2018. PMID: 30071351 Free PMC article.
Altogether, our results demonstrate that this method allowed functional re-endothelialization of liver scaffold and show great potential toward the generation of functional bioengineered liver for long-term transplantation. STATEMENT OF SIGNIFICANCE: There is a critical ne …
Altogether, our results demonstrate that this method allowed functional re-endothelialization of liver scaffold and show great potential tow …
Regulation of Energy Homeostasis After Gastric Bypass Surgery.
Yarmush ML, D'Alessandro M, Saeidi N. Yarmush ML, et al. Annu Rev Biomed Eng. 2017 Jun 21;19:459-484. doi: 10.1146/annurev-bioeng-071813-105140. Annu Rev Biomed Eng. 2017. PMID: 28633561 Review.
RYGB has been the gold standard of bariatric surgery because the beneficial long-term outcomes, which include sustainable weight loss and type 2 diabetes mellitus (T2DM) resolution, are far superior to those obtained with other bariatric surgeries. ...
RYGB has been the gold standard of bariatric surgery because the beneficial long-term outcomes, which include sustainable weight loss …
Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns.
Castleberry SA, Golberg A, Sharkh MA, Khan S, Almquist BD, Austen WG Jr, Yarmush ML, Hammond PT. Castleberry SA, et al. Among authors: yarmush ml. Biomaterials. 2016 Jul;95:22-34. doi: 10.1016/j.biomaterials.2016.04.007. Epub 2016 Apr 14. Biomaterials. 2016. PMID: 27108403 Free PMC article.
The absence of these structures contributes to a number of the long-term morbidities of wound healing, including loss of function for tissues, increased risk of re-injury, and aesthetic complications. ...
The absence of these structures contributes to a number of the long-term morbidities of wound healing, including loss of function for …
Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization.
McCarty WJ, Prodanov L, Bale SS, Bhushan A, Jindal R, Yarmush ML, Usta OB. McCarty WJ, et al. Among authors: yarmush ml. J Vis Exp. 2015 Sep 29;(103):53078. doi: 10.3791/53078. J Vis Exp. 2015. PMID: 26485274 Free PMC article.
These thin collagen layers stabilize cell morphology and function, as shown using primary hepatocytes as an example cell, allowing for the long term culture of microtissues in microfluidic devices....
These thin collagen layers stabilize cell morphology and function, as shown using primary hepatocytes as an example cell, allowing for the l …
Long-term maintenance of a microfluidic 3D human liver sinusoid.
Prodanov L, Jindal R, Bale SS, Hegde M, McCarty WJ, Golberg I, Bhushan A, Yarmush ML, Usta OB. Prodanov L, et al. Among authors: yarmush ml. Biotechnol Bioeng. 2016 Jan;113(1):241-6. doi: 10.1002/bit.25700. Epub 2015 Aug 26. Biotechnol Bioeng. 2016. PMID: 26152452 Free PMC article.
The development of long-term human organotypic liver-on-a-chip models for successful prediction of toxic response is one of the most important and urgent goals of the NIH/DARPA's initiative to replicate and replace chronic and acute drug testing in animals. ...
The development of long-term human organotypic liver-on-a-chip models for successful prediction of toxic response is one of the most …
Supercooling preservation and transplantation of the rat liver.
Bruinsma BG, Berendsen TA, Izamis ML, Yeh H, Yarmush ML, Uygun K. Bruinsma BG, et al. Among authors: yarmush ml. Nat Protoc. 2015 Mar;10(3):484-94. doi: 10.1038/nprot.2015.011. Epub 2015 Feb 18. Nat Protoc. 2015. PMID: 25692985 Free PMC article.
Although it is successful for shorter durations, this method of preservation does not allow long-term storage of the liver. The gradual loss of hepatic viability during preservation puts pressure on organ sharing and allocation, may limit the use of suboptimal grafts and n …
Although it is successful for shorter durations, this method of preservation does not allow long-term storage of the liver. The gradu …
60 results