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Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Taylor S, Ominsky MS, Hu R, Pacheco E, He YD, Brown DL, Aguirre JI, Wronski TJ, Buntich S, Afshari CA, Pyrah I, Nioi P, Boyce RW. Taylor S, et al. Among authors: wronski tj. Bone. 2016 Mar;84:148-159. doi: 10.1016/j.bone.2015.12.013. Epub 2015 Dec 22. Bone. 2016. PMID: 26721737 Free article.
To obtain insight into the temporal cellular and transcriptional changes in the osteoblast (OB) lineage associated with long-term Scl-Ab treatment, stereological and transcriptional analyses of the OB lineage were performed on lumbar vertebrae from aged ovariectomized rats …
To obtain insight into the temporal cellular and transcriptional changes in the osteoblast (OB) lineage associated with long-term Scl …
Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.
Turner RT, Dube M, Branscum AJ, Wong CP, Olson DA, Zhong X, Kweh MF, Larkin IV, Wronski TJ, Rosen CJ, Kalra SP, Iwaniec UT. Turner RT, et al. Among authors: wronski tj. J Endocrinol. 2015 Dec;227(3):129-41. doi: 10.1530/JOE-15-0280. Epub 2015 Oct 20. J Endocrinol. 2015. PMID: 26487675 Free PMC article.
Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effects, including accelerating age-related cancellous bone loss. ...
Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can resu …
Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.
Jackson MA, Iwaniec UT, Turner RT, Wronski TJ, Kalra SP. Jackson MA, et al. Among authors: wronski tj. Peptides. 2011 Aug;32(8):1575-80. doi: 10.1016/j.peptides.2011.04.029. Epub 2011 May 27. Peptides. 2011. PMID: 21640774 Free PMC article.
However, in addition to its direct beneficial effects, leptin has been reported to have indirect (central nervous system-mediated) antiosteogenic effects on bone, which may limit the efficacy of elevated serum leptin to prevent estrogen deficiency-associated bone loss. The presen …
However, in addition to its direct beneficial effects, leptin has been reported to have indirect (central nervous system-mediated) antiosteo …
Skeletal effects of fibroblast growth factor mimetic (F2A) in ovariectomized rats.
Aguirre JI, Franz SE, Altman MK, Stabley JN, Lin X, Zamora PO, Wronski TJ. Aguirre JI, et al. Among authors: wronski tj. J Musculoskelet Neuronal Interact. 2009 Jan-Mar;9(1):38-43. J Musculoskelet Neuronal Interact. 2009. PMID: 19240367 Free article.
The current study was designed to determine whether short-term, systemic treatment with F2A, a mimetic for FGF-2, has skeletal effects in ovariectomized (OVX) rats and adverse side effects in non-skeletal tissues. ...
The current study was designed to determine whether short-term, systemic treatment with F2A, a mimetic for FGF-2, has skeletal effect …
Selected extraskeletal effects of systemic treatment with basic fibroblast growth factor in ovariectomized rats.
Wamsley HL, Iwaniec UT, Wronski TJ. Wamsley HL, et al. Among authors: wronski tj. Toxicol Pathol. 2005;33(5):577-83. doi: 10.1080/01926230500243060. Toxicol Pathol. 2005. PMID: 16105801
Though bFGF strongly stimulates bone formation at osteopenic skeletal sites, its extraskeletal effects may restrict the long-term use of bFGF in its current form as an osteoporosis therapy....
Though bFGF strongly stimulates bone formation at osteopenic skeletal sites, its extraskeletal effects may restrict the long-term use …
Skeletal effects of systemic treatment with basic fibroblast growth factor.
Wronski TJ. Wronski TJ. J Musculoskelet Neuronal Interact. 2001 Sep;2(1):9-14. J Musculoskelet Neuronal Interact. 2001. PMID: 15758472 Free article.
These effects include marked increases in osteoblast number and activity along cancellous and endocortical bone surfaces, which result in accumulation of osteoid and augmentation of cancellous and cortical bone mass after only short-term treatment with bFGF. Osteoclast sur …
These effects include marked increases in osteoblast number and activity along cancellous and endocortical bone surfaces, which result in ac …
Effects of disrupted beta1-integrin function on the skeletal response to short-term hindlimb unloading in mice.
Iwaniec UT, Wronski TJ, Amblard D, Nishimura Y, van der Meulen MC, Wade CE, Bourgeois MA, Damsky CD, Globus RK. Iwaniec UT, et al. Among authors: wronski tj. J Appl Physiol (1985). 2005 Feb;98(2):690-6. doi: 10.1152/japplphysiol.00689.2004. Epub 2004 Oct 1. J Appl Physiol (1985). 2005. PMID: 15465888 Free article.
However, the strength and stiffness of the femoral diaphysis were unaffected by short-term hindlimb unloading in both genotypes. The observed increase in osteoclast surface was greater in unloaded TG mice (92%) than in unloaded WT mice (52%). ...
However, the strength and stiffness of the femoral diaphysis were unaffected by short-term hindlimb unloading in both genotypes. The …
Spaceflight alters bone mechanics and modeling drifts in growing rats.
Vajda EG, Wronski TJ, Halloran BP, Bachus KN, Miller SC. Vajda EG, et al. Among authors: wronski tj. Aviat Space Environ Med. 2001 Aug;72(8):720-6. Aviat Space Environ Med. 2001. PMID: 11506233
BACKGROUND: Alterations in bone metabolism may be a particularly serious consequence of spaceflight and a major obstacle to long-term space exploration. The effects of spaceflight on bone mechanics are unclear. ...
BACKGROUND: Alterations in bone metabolism may be a particularly serious consequence of spaceflight and a major obstacle to long-term …
Skeletal effects of calcitonin treatment and withdrawal in ovariectomized rats.
Shen Y, Li M, Wronski TJ. Shen Y, et al. Among authors: wronski tj. Calcif Tissue Int. 1996 Apr;58(4):263-7. doi: 10.1007/BF02508646. Calcif Tissue Int. 1996. PMID: 8661958
The study was designed to determine, by histomorphometric techniques, bone changes as a function of time during long-term treatment with salmon calcitonin (CT) and after withdrawal of the hormone in ovariectomized (OVX) rats. ...
The study was designed to determine, by histomorphometric techniques, bone changes as a function of time during long-term treatment w …
17 results