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Impacts of heat exposure in utero on long-term health and social outcomes: a systematic review.
Brink N, Lakhoo DP, Solarin I, Maimela G, von Dadelszen P, Norris S, Chersich MF; Climate and Heat-Health Study Group. Brink N, et al. BMC Pregnancy Childbirth. 2024 May 4;24(1):344. doi: 10.1186/s12884-024-06512-0. BMC Pregnancy Childbirth. 2024. PMID: 38704541 Free PMC article.
BACKGROUND: Climate change, particularly global warming, is amongst the greatest threats to human health. While short-term effects of heat exposure in pregnancy, such as preterm birth, are well documented, long-term effects have received less attention. This …
BACKGROUND: Climate change, particularly global warming, is amongst the greatest threats to human health. While short-term effects of …
Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms.
Ziegler KF, Joshi K, Wright CS, Roy S, Caruso W, Biswas RR, Iyer-Biswas S. Ziegler KF, et al. Among authors: wright cs. Mol Biol Cell. 2024 Jun 1;35(6):ar78. doi: 10.1091/mbc.E23-11-0452. Epub 2024 Apr 10. Mol Biol Cell. 2024. PMID: 38598301
Microfluidic platforms enable long-term quantification of stochastic behaviors of individual bacterial cells under precisely controlled growth conditions. ...
Microfluidic platforms enable long-term quantification of stochastic behaviors of individual bacterial cells under precisely controll …
An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii.
Zhang J, Huang YJ, Trapecar M, Wright C, Schneider K, Kemmitt J, Hernandez-Gordillo V, Yoon JY, Poyet M, Alm EJ, Breault DT, Trumper DL, Griffith LG. Zhang J, et al. Among authors: wright c. NPJ Biofilms Microbiomes. 2024 Mar 29;10(1):31. doi: 10.1038/s41522-024-00501-z. NPJ Biofilms Microbiomes. 2024. PMID: 38553449 Free PMC article.
Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes, hindering the understanding of …
Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long- …
Association between long-term use of calcium channel blockers (CCB) and the risk of breast cancer: a retrospective longitudinal observational study protocol.
Ho C, Ha NT, Youens D, Abhayaratna WP, Bulsara MK, Hughes JD, Mishra G, Pearson SA, Preen DB, Reid CM, Ruiter R, Saunders CM, Stricker BH, van Rooij FJA, Wright C, Moorin R. Ho C, et al. Among authors: wright c. BMJ Open. 2024 Mar 8;14(3):e080982. doi: 10.1136/bmjopen-2023-080982. BMJ Open. 2024. PMID: 38458796 Free PMC article.
INTRODUCTION: Calcium channel blockers (CCB), a commonly prescribed antihypertensive (AHT) medicine, may be associated with increased risk of breast cancer. The proposed study aims to examine whether long-term CCB use is associated with the development of breast cancer and …
INTRODUCTION: Calcium channel blockers (CCB), a commonly prescribed antihypertensive (AHT) medicine, may be associated with increased risk o …
Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver.
Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ. Grayck MR, et al. Among authors: wright cj. Pediatr Res. 2024 Feb 23. doi: 10.1038/s41390-024-03071-0. Online ahead of print. Pediatr Res. 2024. PMID: 38396130
More work is needed to determine if this contributes to long-term hepatic dysfunction, and whether immunomodulatory approaches can prevent this injury. ...We believe that these results may explain in part hepatic dysfunction with neonatal sepsis, and that there may be unre …
More work is needed to determine if this contributes to long-term hepatic dysfunction, and whether immunomodulatory approaches can pr …
Comparative genomics reveals the dynamics of chromosome evolution in Lepidoptera.
Wright CJ, Stevens L, Mackintosh A, Lawniczak M, Blaxter M. Wright CJ, et al. Nat Ecol Evol. 2024 Apr;8(4):777-790. doi: 10.1038/s41559-024-02329-4. Epub 2024 Feb 21. Nat Ecol Evol. 2024. PMID: 38383850 Free PMC article.
Here we analyse 210 chromosomally complete lepidopteran genomes and show that the chromosomes of extant lepidopterans are derived from 32 ancestral linkage groups, which we term Merian elements. Merian elements have remained largely intact through 250 million years of evol …
Here we analyse 210 chromosomally complete lepidopteran genomes and show that the chromosomes of extant lepidopterans are derived from 32 an …
Kumanu Tāngata: the aftermatch study - protocol to examine the health outcomes of high-level male rugby union players using linked administrative data.
D'Souza S, Milne BJ, Li C, Anns F, Gardner A, Lumley T, Morton SMB, Murphy IR, Verhagen E, Wright C, Quarrie K. D'Souza S, et al. Among authors: wright c. BMJ Open Sport Exerc Med. 2024 Feb 14;10(1):e001795. doi: 10.1136/bmjsem-2023-001795. eCollection 2024. BMJ Open Sport Exerc Med. 2024. PMID: 38362564 Free PMC article.
There is increasing interest in the potential long-term outcomes of participation in contact and collision sports, driven by evidence of higher rates of neurodegenerative diseases among former athletes. ...
There is increasing interest in the potential long-term outcomes of participation in contact and collision sports, driven by evidence …
Alliance for clinical trials in Oncology (Alliance) trial A022101/NRG-GI009: a pragmatic randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: evaluating radiation, ablation, and surgery (ERASur).
Hitchcock KE, Miller ED, Shi Q, Dixon JG, Gholami S, White SB, Wu C, Goulet CC, George M, Jee KW, Wright CL, Yaeger R, Shergill A, Hong TS, George TJ, O'Reilly EM, Meyerhardt JA, Romesser PB. Hitchcock KE, et al. Among authors: wright cl. BMC Cancer. 2024 Feb 13;24(1):201. doi: 10.1186/s12885-024-11899-2. BMC Cancer. 2024. PMID: 38350888 Free PMC article. Clinical Trial.
BACKGROUND: For patients with liver-confined metastatic colorectal cancer (mCRC), local therapy of isolated metastases has been associated with long-term progression-free and overall survival (OS). However, for patients with more advanced mCRC, including those with extrahe …
BACKGROUND: For patients with liver-confined metastatic colorectal cancer (mCRC), local therapy of isolated metastases has been associated w …
Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells.
Desmond LW, Holbrook EM, Wright CTO, Zambrano CA, Stamper CE, Bohr AD, Frank MG, Podell BK, Moreno JA, MacDonald AS, Reber SO, Hernández-Pando R, Lowry CA. Desmond LW, et al. Among authors: wright cto. Int J Mol Sci. 2023 Dec 29;25(1):474. doi: 10.3390/ijms25010474. Int J Mol Sci. 2023. PMID: 38203645 Free PMC article.
Thus, M. vaccae NCTC 11659 acutely (within 48 h) induced immune-activating and microglial-priming effects when applied directly to murine BV-2 microglial cells, in contrast to its long-term anti-inflammatory and immunoregulatory effects observed on the CNS when whole-cell, …
Thus, M. vaccae NCTC 11659 acutely (within 48 h) induced immune-activating and microglial-priming effects when applied directly to murine BV …
319 results