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COVID-related disruptions to colorectal cancer screening, diagnosis, and treatment could increase cancer Burden in Australia and Canada: A modelling study.
Worthington J, Sun Z, Fu R, Lew JB, Chan KKW, Li Q, Eskander A, Hui H, McLoughlin K, Caruana M, Peacock S, Yong JHE, Canfell K, Feletto E, Malagón T. Worthington J, et al. PLoS One. 2024 Apr 1;19(4):e0296945. doi: 10.1371/journal.pone.0296945. eCollection 2024. PLoS One. 2024. PMID: 38557758 Free PMC article.
This modelling study estimates the impact of disruptions on colorectal cancer cases and deaths in Canada and Australia, informed by data on screening, diagnosis, and treatment procedures. Modelling was used to estimate short- and long-term effects on colorectal cancer inci …
This modelling study estimates the impact of disruptions on colorectal cancer cases and deaths in Canada and Australia, informed by data on …
Potential global loss of life expected due to COVID-19 disruptions to organised colorectal cancer screening.
Worthington J, van Wifferen F, Sun Z, de Jonge L, Lew JB, Greuter MJE, van den Puttelaar R, Feletto E, Lansdorp-Vogelaar I, Coupé VMH, Ein Yong JH, Canfell K; I-PaRCS Consortium. Worthington J, et al. EClinicalMedicine. 2023 Jul 20;62:102081. doi: 10.1016/j.eclinm.2023.102081. eCollection 2023 Aug. EClinicalMedicine. 2023. PMID: 37538541 Free PMC article.
Four independent microsimulation models (ASCCA, MISCAN-Colon, OncoSim, and Policy1-Bowel) were used to estimate the long-term impact on CRC cases and deaths, based on decreases to screening participation in 2020. ...
Four independent microsimulation models (ASCCA, MISCAN-Colon, OncoSim, and Policy1-Bowel) were used to estimate the long-term impact …
Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain.
Piwowarczyk-Nowak A, Pałasz A, Bogus K, Krzystanek M, Błaszczyk I, Worthington JJ, Grajoszek A. Piwowarczyk-Nowak A, et al. Among authors: worthington jj. Mol Biol Rep. 2022 Sep;49(9):9041-9049. doi: 10.1007/s11033-022-07578-9. Epub 2022 Jun 11. Mol Biol Rep. 2022. PMID: 35690686
The present work was therefore focused on local expression of the aforementioned stress-related neuropeptides in the rat brain after long-term treatment with escitalopram and clonazepam. METHODS: Studies were carried out on adult, male Sprague-Dawley rats that were divided …
The present work was therefore focused on local expression of the aforementioned stress-related neuropeptides in the rat brain after long- …
Qualitative Assessment of the Conservative Management of Nocturia with Standardised Written Materials for Lower Urinary Tract Symptoms in Men Treated in Primary Care.
Olaniyi P, Cotterill N, Drake MJ, Frost J, Lane JA, Ridd M, Robles L, Taylor G, Worthington J, Wheeler J. Olaniyi P, et al. Among authors: worthington j. Eur Urol Focus. 2022 Jan;8(1):75-80. doi: 10.1016/j.euf.2022.01.003. Epub 2022 Jan 13. Eur Urol Focus. 2022. PMID: 35034867 Clinical Trial.
The TRIUMPH LUTS intervention booklet offers explanations and self-management guidance. Men with long-term disruptive symptoms, a perception that the booklet content was novel or worthwhile, and a belief that self-management might help, were more receptive to the intervent …
The TRIUMPH LUTS intervention booklet offers explanations and self-management guidance. Men with long-term disruptive symptoms, a per …
Antipsychotics increase steroidogenic enzyme gene expression in the rat brainstem.
Bogus K, Żarczyńska M, Pałasz A, Suszka-Świtek A, Worthington JJ, Krzystanek M, Żarczyński P. Bogus K, et al. Among authors: worthington jj. Mol Biol Rep. 2022 Feb;49(2):1601-1608. doi: 10.1007/s11033-021-06943-4. Epub 2021 Nov 19. Mol Biol Rep. 2022. PMID: 34797492 Free PMC article.
Total mRNA was isolated from homogenized brainstem samples for RealTime-PCR to estimate gene expression of related aromatase, 3beta-HSD and P450scc. Long-term treatment with the selected antipsychotics was reflected in the modulation of steroidogenic enzyme gene expression …
Total mRNA was isolated from homogenized brainstem samples for RealTime-PCR to estimate gene expression of related aromatase, 3beta-HSD and …
Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem.
Pałasz A, Żarczyński P, Bogus K, Mordecka-Chamera K, Della Vecchia A, Skałbania J, Worthington JJ, Krzystanek M, Żarczyńska M. Pałasz A, et al. Among authors: worthington jj. Pharmacol Rep. 2021 Aug;73(4):1188-1194. doi: 10.1007/s43440-021-00267-7. Epub 2021 Apr 29. Pharmacol Rep. 2021. PMID: 33928538 Free PMC article.
Total mRNA was isolated from homogenized samples of both structures and the RT-PCR method was used for estimation of related SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expression. RESULTS: Long-term treatment with olanzapine is reflected in qualitatively differ …
Total mRNA was isolated from homogenized samples of both structures and the RT-PCR method was used for estimation of related SMIM20/phoenixi …
Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
Skałbania J, Pałasz A, Błaszczyk I, Suszka-Świtek A, Krzystanek M, Tulcanaz KP, Worthington JJ, Mordecka-Chamera K. Skałbania J, et al. Among authors: worthington jj. Pharmacol Rep. 2021 Aug;73(4):1164-1169. doi: 10.1007/s43440-021-00259-7. Epub 2021 Apr 12. Pharmacol Rep. 2021. PMID: 33843023 Free PMC article.
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation....
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progeni …
Olanzapine Increases Neural Chemorepulsant-Draxin Expression in the Adult Rat Hippocampus.
Pałasz A, Suszka-Świtek A, Francikowski J, Krzystanek M, Bogus K, Skałbania J, Worthington JJ, Mrzyk I. Pałasz A, et al. Among authors: worthington jj. Pharmaceuticals (Basel). 2021 Mar 27;14(4):298. doi: 10.3390/ph14040298. Pharmaceuticals (Basel). 2021. PMID: 33801609 Free PMC article.
After analysis of local fluorescence intensity, we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ) and granular zone of the rat hippocampus following long-term olanzapine administration. This study reveals, for the first time, the …
After analysis of local fluorescence intensity, we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ …
Impact of the COVID-19 pandemic on faecal immunochemical test-based colorectal cancer screening programmes in Australia, Canada, and the Netherlands: a comparative modelling study.
de Jonge L, Worthington J, van Wifferen F, Iragorri N, Peterse EFP, Lew JB, Greuter MJE, Smith HA, Feletto E, Yong JHE, Canfell K, Coupé VMH, Lansdorp-Vogelaar I; COVID-19 and Cancer Global Modelling Consortium working group 2. de Jonge L, et al. Among authors: worthington j. Lancet Gastroenterol Hepatol. 2021 Apr;6(4):304-314. doi: 10.1016/S2468-1253(21)00003-0. Epub 2021 Feb 3. Lancet Gastroenterol Hepatol. 2021. PMID: 33548185 Free PMC article.
We aimed to estimate the impact of hypothetical disruptions to organised faecal immunochemical test-based colorectal cancer screening programmes on short-term and long-term colorectal cancer incidence and mortality in three countries using microsimulation modelling. …
We aimed to estimate the impact of hypothetical disruptions to organised faecal immunochemical test-based colorectal cancer screening progra …
Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain.
Pałasz A, Piwowarczyk-Nowak A, Suszka-Świtek A, Bogus K, Filipczyk Ł, Vecchia AD, Mordecka-Chamera K, Menezes IC, Worthington JJ, Krzystanek M, Wiaderkiewicz R. Pałasz A, et al. Among authors: worthington jj. Mol Biol Rep. 2020 Oct;47(10):8273-8278. doi: 10.1007/s11033-020-05806-8. Epub 2020 Sep 10. Mol Biol Rep. 2020. PMID: 32914264 Free PMC article.
In the current study we examined POMC, kisspeptin, Kiss1R and MCHR1 mRNA expression in the selected brain structures (hypothalamus, hippocampus, amygdala, striatum, cerebellum and brainstem) of rats chronically treated with a 10 mg/kg dose of escitalopram using quantitative Real- …
In the current study we examined POMC, kisspeptin, Kiss1R and MCHR1 mRNA expression in the selected brain structures (hypothalamus, hippocam …
38 results