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Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia.
Schuermans A, Truong B, Ardissino M, Bhukar R, Slob EAW, Nakao T, Dron JS, Small AM, Cho SMJ, Yu Z, Hornsby W, Antoine T, Lannery K, Postupaka D, Gray KJ, Yan Q, Butterworth AS, Burgess S, Wood MJ, Scott NS, Harrington CM, Sarma AA, Lau ES, Roh JD, Januzzi JL Jr, Natarajan P, Honigberg MC. Schuermans A, et al. Among authors: wood mj. JAMA Cardiol. 2024 Mar 1;9(3):209-220. doi: 10.1001/jamacardio.2023.4994. JAMA Cardiol. 2024. PMID: 38170504 Free PMC article.
IMPORTANCE: Hypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease. OB …
IMPORTANCE: Hypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to m …
A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models.
Hoolachan JM, McCallion E, Sutton ER, Çetin Ö, Pacheco-Torres P, Dimitriadi M, Sari S, Miller GJ, Okoh M, Walter LM, Claus P, Wood MJA, Tonge DP, Bowerman M. Hoolachan JM, et al. Among authors: wood mja. Hum Mol Genet. 2024 Feb 18;33(5):400-425. doi: 10.1093/hmg/ddad192. Hum Mol Genet. 2024. PMID: 37947217 Free PMC article.
We have previously demonstrated that prednisolone, a synthetic glucocorticoid (GC) improved muscle health and survival in severe Smn-/-;SMN2 and intermediate Smn2B/- SMA mice. However, long-term administration of prednisolone can promote myopathy. We thus wanted to identif …
We have previously demonstrated that prednisolone, a synthetic glucocorticoid (GC) improved muscle health and survival in severe Smn-/-;SMN2 …
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.
Gross R, Thaweethai T, Rosenzweig EB, Chan J, Chibnik LB, Cicek MS, Elliott AJ, Flaherman VJ, Foulkes AS, Witvliet MG, Gallagher R, Gennaro ML, Jernigan TL, Karlson EW, Katz SD, Kinser PA, Kleinman LC, Lamendola-Essel MF, Milner JD, Mohandas S, Mudumbi PC, Newburger JW, Rhee KE, Salisbury AL, Snowden JN, Stein CR, Stockwell MS, Tantisira KG, Thomason ME, Truong DT, Warburton D, Wood JC, Ahmed S, Akerlundh A, Alshawabkeh AN, Anderson BR, Aschner JL, Atz AM, Aupperle RL, Baker FC, Balaraman V, Banerjee D, Barch DM, Baskin-Sommers A, Bhuiyan S, Bind MC, Bogie AL, Buchbinder NC, Bueler E, Bükülmez H, Casey BJ, Chang L, Clark DB, Clifton RG, Clouser KN, Cottrell L, Cowan K, D'Sa V, Dapretto M, Dasgupta S, Dehority W, Dummer KB, Elias MD, Esquenazi-Karonika S, Evans DN, Faustino EVS, Fiks AG, Forsha D, Foxe JJ, Friedman NP, Fry G, Gaur S, Gee DG, Gray KM, Harahsheh AS, Heath AC, Heitzeg MM, Hester CM, Hill S, Hobart-Porter L, Hong TKF, Horowitz CR, Hsia DS, Huentelman M, Hummel KD, Iacono WG, Irby K, Jacobus J, Jacoby VL, Jone PN, Kaelber DC, Kasmarcak TJ, Kluko MJ, Kosut JS, Laird AR, Landeo-Gutierrez J, Lang SM, Larson CL, Lim PPC, Lisdahl KM, McCrindle BW, McCulloh RJ, Mendelsohn AL,… See abstract for full author list ➔ Gross R, et al. Among authors: wood mj. medRxiv [Preprint]. 2023 May 12:2023.04.27.23289228. doi: 10.1101/2023.04.27.23289228. medRxiv. 2023. PMID: 37214806 Free PMC article. Updated. Preprint.
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. ...CONCLUSIONS AND RELEVANCE: RECOVER-Pediatrics seeks to characterize the clinical cours …
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long CO …
Multimodality Imaging in the Detection of Ischemic Heart Disease in Women.
Gaine SP, Sharma G, Tower-Rader A, Botros M, Kovell L, Parakh A, Wood MJ, Harrington CM. Gaine SP, et al. Among authors: wood mj. J Cardiovasc Dev Dis. 2022 Oct 13;9(10):350. doi: 10.3390/jcdd9100350. J Cardiovasc Dev Dis. 2022. PMID: 36286302 Free PMC article. Review.
Women with coronary artery disease tend to have a worse short and long-term prognosis relative to men and the incidence of atherosclerotic cardiovascular disease is increasing. ...
Women with coronary artery disease tend to have a worse short and long-term prognosis relative to men and the incidence of atheroscle …
Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
Patutina OA, Gaponova Miroshnichenko SK, Sen'kova AV, Savin IA, Gladkikh DV, Burakova EA, Fokina AA, Maslov MA, Shmendel' EV, Wood MJA, Vlassov VV, Altman S, Stetsenko DA, Zenkova MA. Patutina OA, et al. Among authors: wood mja. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32370-32379. doi: 10.1073/pnas.2016158117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288723 Free PMC article.
Herein, using a xenograft mouse tumor model, it was demonstrated that microRNA miR-21-targeted -oligonucleotides administered in complex with folate-containing liposomes dramatically inhibit primary tumor growth via long-term down-regulation of miR-21 in tumors and increas …
Herein, using a xenograft mouse tumor model, it was demonstrated that microRNA miR-21-targeted -oligonucleotides administered in complex wit …
Sampling strategies for species with high breeding-site fidelity: A case study in burrow-nesting seabirds.
Arneill GE, Perrins CM, Wood MJ, Murphy D, Pisani L, Jessopp MJ, Quinn JL. Arneill GE, et al. Among authors: wood mj. PLoS One. 2019 Aug 27;14(8):e0221625. doi: 10.1371/journal.pone.0221625. eCollection 2019. PLoS One. 2019. PMID: 31454375 Free PMC article.
Usually the approach taken is determined by the spatial and temporal distribution of the study population, along with other characteristics of the focal species. Long-term monitoring programs used to assess seabird population trends are facilitated by their high site fidel …
Usually the approach taken is determined by the spatial and temporal distribution of the study population, along with other characteristics …
Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.
Betts CA, McClorey G, Healicon R, Hammond SM, Manzano R, Muses S, Ball V, Godfrey C, Merritt TM, van Westering T, O'Donovan L, Wells KE, Gait MJ, Wells DJ, Tyler D, Wood MJ. Betts CA, et al. Among authors: wood mj. Hum Mol Genet. 2019 Feb 1;28(3):396-406. doi: 10.1093/hmg/ddy346. Hum Mol Genet. 2019. PMID: 30281092 Free PMC article.
Early upregulation of mitochondrial genes (Ucp3 and Cpt1) and downregulation of key glycolytic genes (Pdk1, Pdk4, Ppara), also denote disturbed cardiac metabolism and shift towards glucose utilization in Cmah-/-;mdx mice. Moreover, we show long-term treatment with peptide- …
Early upregulation of mitochondrial genes (Ucp3 and Cpt1) and downregulation of key glycolytic genes (Pdk1, Pdk4, Ppara), also denote distur …
Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association.
Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Hayes SN, et al. Among authors: wood mj. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22. Circulation. 2018. PMID: 29472380 Free PMC article. Review.
Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than …
Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series …
Therapeutic strategies for spinal muscular atrophy: SMN and beyond.
Bowerman M, Becker CG, Yáñez-Muñoz RJ, Ning K, Wood MJA, Gillingwater TH, Talbot K; UK SMA Research Consortium. Bowerman M, et al. Among authors: wood mja. Dis Model Mech. 2017 Aug 1;10(8):943-954. doi: 10.1242/dmm.030148. Dis Model Mech. 2017. PMID: 28768735 Free PMC article. Review.
However, several factors suggest that complementary strategies may be needed for the long-term maintenance of neuromuscular and other functions in SMA patients. ...
However, several factors suggest that complementary strategies may be needed for the long-term maintenance of neuromuscular and other …
33 results