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Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells.
Natsume N, Yamano A, Watanabe A, Yonezawa T, Woo JT, Yamakuni T, Teruya T. Natsume N, et al. Among authors: woo jt. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127606. doi: 10.1016/j.bmcl.2020.127606. Epub 2020 Oct 7. Bioorg Med Chem Lett. 2020. PMID: 33038547
The cAMP-response element (CRE) is critical in the formation of long-term memory. To prove the pharmacological effects of the methoxyflavones-rich residue (MRR) and its constituent methoxyflavones (1-9) extracted from the rhizomes of Kaempferia parviflora on the nervous sy …
The cAMP-response element (CRE) is critical in the formation of long-term memory. To prove the pharmacological effects of the methoxy …
Efficacy and Tolerability of Pitavastatin Versus Pitavastatin/Fenofibrate in High-risk Korean Patients with Mixed Dyslipidemia: A Multicenter, Randomized, Double-blinded, Parallel, Therapeutic Confirmatory Clinical Trial.
Ihm SH, Chung WB, Lee JM, Hwang BH, Yoo KD, Her SH, Song WH, Chae IH, Park TH, Kim JH, Jeon DW, Cho BR, Kang SH, Park SD, Lee JB, Woo JT, Lee BW, Han KA, Won KH, Kim HS, Yu JM, Chung CH, Kim HJ, Cho HC, Seung KB. Ihm SH, et al. Among authors: woo jt. Clin Ther. 2020 Oct;42(10):2021-2035.e3. doi: 10.1016/j.clinthera.2020.08.002. Epub 2020 Sep 2. Clin Ther. 2020. PMID: 32891418 Free article. Clinical Trial.
All participants in the extension study received the pitavastatin/fenofibrate combination therapy for 16 weeks for the assessment of the tolerability of long-term treatment. FINDINGS: The difference in the mean percentage change in non-HDL-C from baseline to week 8 between …
All participants in the extension study received the pitavastatin/fenofibrate combination therapy for 16 weeks for the assessment of the tol …
Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes.
Chin SO, Ha IG, Rhee SY, Jeong SJ, Chon S, Kim SH, Ahn KJ, Baik SH, Park Y, Nam MS, Lee KW, Woo JT. Chin SO, et al. Among authors: woo jt. Int J Endocrinol. 2020 Jul 24;2020:9879517. doi: 10.1155/2020/9879517. eCollection 2020. Int J Endocrinol. 2020. PMID: 32774367 Free PMC article.
CONCLUSIONS: There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affe …
CONCLUSIONS: There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin u …
Supplementation of the Flavonoid Myricitrin Attenuates the Adverse Metabolic Effects of Long-Term Consumption of a High-Fat Diet in Mice.
Kim YJ, Kim SR, Kim DY, Woo JT, Kwon EY, Han Y, Choi MS, Jung UJ. Kim YJ, et al. Among authors: woo jt. J Med Food. 2019 Nov;22(11):1151-1158. doi: 10.1089/jmf.2018.4341. Epub 2019 Sep 24. J Med Food. 2019. PMID: 31549892
Myricitrin-supplemented mice also showed improved glucose tolerance, insulin sensitivity, and decreased hyperinsulinemia, along with decreased levels of circulating resistin. In conclusion, long-term consumption of a myricitrin-supplemented diet may effectively protect aga …
Myricitrin-supplemented mice also showed improved glucose tolerance, insulin sensitivity, and decreased hyperinsulinemia, along with decreas …
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial.
Heerspink HJL, Parving HH, Andress DL, Bakris G, Correa-Rotter R, Hou FF, Kitzman DW, Kohan D, Makino H, McMurray JJV, Melnick JZ, Miller MG, Pergola PE, Perkovic V, Tobe S, Yi T, Wigderson M, de Zeeuw D; SONAR Committees and Investigators. Heerspink HJL, et al. Lancet. 2019 May 11;393(10184):1937-1947. doi: 10.1016/S0140-6736(19)30772-X. Epub 2019 Apr 14. Lancet. 2019. PMID: 30995972 Clinical Trial.
BACKGROUND: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasen …
BACKGROUND: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist a …
Long-term effects on glycaemic control and beta-cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial.
Chon S, Rhee SY, Ahn KJ, Baik SH, Park Y, Nam MS, Lee KW, Yoo SJ, Koh G, Lee DH, Kim YS, Woo JT; KIIT study investigators. Chon S, et al. Among authors: woo jt. Diabetes Obes Metab. 2018 May;20(5):1121-1130. doi: 10.1111/dom.13196. Epub 2018 Jan 22. Diabetes Obes Metab. 2018. PMID: 29272062 Clinical Trial.
AIM: To determine the effects of early intensive glycaemic control with intensive insulin treatment (IIT) or initial combined oral antidiabetic drug (COAD) therapy on long-term glycaemic control and the preservation of beta-cell function in people with type 2 diabetes mell …
AIM: To determine the effects of early intensive glycaemic control with intensive insulin treatment (IIT) or initial combined oral antidiabe …
Liraglutide and Renal Outcomes in Type 2 Diabetes.
Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB; LEADER Steering Committee and Investigators. Mann JFE, et al. N Engl J Med. 2017 Aug 31;377(9):839-848. doi: 10.1056/NEJMoa1616011. N Engl J Med. 2017. PMID: 28854085 Free article. Clinical Trial.
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary …
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with t …
Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity.
Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ. Kim YJ, et al. Among authors: woo jt. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600889. Epub 2017 Mar 2. Mol Nutr Food Res. 2017. PMID: 28116779
SCOPE: We evaluated the long-term effect of low-dose nobiletin (NOB), a polymethoxylated flavone, on diet-induced obesity and related metabolic disturbances. ...Hepatic proinflammatory TNF-alpha mRNA expression, collagen accumulation, and plasma levels of aminotransferases …
SCOPE: We evaluated the long-term effect of low-dose nobiletin (NOB), a polymethoxylated flavone, on diet-induced obesity and related …
Short-term intensive insulin therapy at diagnosis in type 2 diabetes: plan for filling the gaps.
Weng J, Retnakaran R, Ariachery C A, Ji L, Meneghini L, Yang W, Woo JT. Weng J, et al. Among authors: woo jt. Diabetes Metab Res Rev. 2015 Sep;31(6):537-44. doi: 10.1002/dmrr.2603. Epub 2014 Nov 18. Diabetes Metab Res Rev. 2015. PMID: 25196375 Review.
Short-term intensive insulin therapy is unique amongst therapies for type 2 diabetes because it offers the potential to preserve and improve beta-cell function without additional pharmacological treatment. On the basis of clinical experience and the promising results of a …
Short-term intensive insulin therapy is unique amongst therapies for type 2 diabetes because it offers the potential to preserve and …
Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults: a retrospective study based on the oral glucose tolerance test.
Hwang YC, Jung CH, Ahn HY, Jeon WS, Jin SM, Woo JT, Cha BS, Kim JH, Park CY, Lee BW. Hwang YC, et al. Among authors: woo jt. Clin Chim Acta. 2014 Nov 1;437:1-5. doi: 10.1016/j.cca.2014.06.027. Epub 2014 Jul 4. Clin Chim Acta. 2014. PMID: 25007953
INTRODUCTION: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-diabetes and diabetes in Korean adults. ...
INTRODUCTION: Glycated albumin (GA) reflects short-term status of glycemic control. We suggest a GA cut-off value to diagnose pre-dia …
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