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Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation.
Wong HR, Reeder RW, Banks R, Berg RA, Meert KL, Hall MW, McQuillen PS, Mourani PM, Chima RS, Sorenson S, Varni JW, McGalliard J, Zimmerman JJ; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN) and the Life After Pediatric Sepsis Evaluation (LAPSE) Investigators. Wong HR, et al. Pediatr Crit Care Med. 2021 Jan 1;22(1):8-15. doi: 10.1097/PCC.0000000000002572. Pediatr Crit Care Med. 2021. PMID: 33003178 Free PMC article.
We determined if the Pediatric Sepsis Biomarker Risk Model biomarkers have predictive capacity for estimating the risk of hospital mortality and long-term health-related quality-of-life morbidity among children with community-acquired septic shock. ...These findings sugges …
We determined if the Pediatric Sepsis Biomarker Risk Model biomarkers have predictive capacity for estimating the risk of hospital mortality …
Beyond Survival: Pediatric Critical Care Interventional Trial Outcome Measure Preferences of Families and Healthcare Professionals.
Merritt C, Menon K, Agus MSD, Choong K, McNally D, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Zimmerman JJ. Merritt C, et al. Among authors: wong hr. Pediatr Crit Care Med. 2018 Feb;19(2):e105-e111. doi: 10.1097/PCC.0000000000001409. Pediatr Crit Care Med. 2018. PMID: 29394234
Duration of organ dysfunction was identified by 70.0% of family care providers and 40.7% of healthcare professionals as the second most preferred outcome measure. CONCLUSIONS: In addition to survival, long-term quality of life/functional status and duration of organ dysfun …
Duration of organ dysfunction was identified by 70.0% of family care providers and 40.7% of healthcare professionals as the second most pref …
High Frequency of Neuroimaging Abnormalities Among Pediatric Patients With Sepsis Who Undergo Neuroimaging.
Sandquist MK, Clee MS, Patel SK, Howard KA, Yunger T, Nagaraj UD, Jones BV, Fei L, Vadivelu S, Wong HR. Sandquist MK, et al. Among authors: wong hr. Pediatr Crit Care Med. 2017 Jul;18(7):607-613. doi: 10.1097/PCC.0000000000001173. Pediatr Crit Care Med. 2017. PMID: 28498230 Free PMC article.
CONCLUSIONS: The majority of pediatric patients with sepsis and concurrent or subsequent neuroimaging have abnormal neuroimaging findings. The implications of this high incidence for long-term neurologic outcomes and follow-up require further exploration....
CONCLUSIONS: The majority of pediatric patients with sepsis and concurrent or subsequent neuroimaging have abnormal neuroimaging findings. T …
Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review.
Menon K, McNally JD, Zimmerman JJ, Agus MS, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Choong K. Menon K, et al. Among authors: wong hr. Pediatr Crit Care Med. 2017 Mar;18(3):e146-e154. doi: 10.1097/PCC.0000000000001078. Pediatr Crit Care Med. 2017. PMID: 28099233 Free PMC article. Review.
CONCLUSIONS: Our review found that use of mortality alone as a primary outcome in pediatric septic shock trials was associated with significant limitations and that long-term patient-centered outcomes were not used in this setting. Composite outcomes incorporating mortalit …
CONCLUSIONS: Our review found that use of mortality alone as a primary outcome in pediatric septic shock trials was associated with signific …
Histological chorioamnionitis shapes the neonatal transcriptomic immune response.
Weitkamp JH, Guthrie SO, Wong HR, Moldawer LL, Baker HV, Wynn JL. Weitkamp JH, et al. Among authors: wong hr. Early Hum Dev. 2016 Jul;98:1-6. doi: 10.1016/j.earlhumdev.2016.06.001. Epub 2016 Jun 16. Early Hum Dev. 2016. PMID: 27318328 Free PMC article.
BACKGROUND: Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including sepsis and necrotizing enterocolitis. ...CONCLUSIONS: Exposure to HCA distinctively activates the neonatal immune system in utero with pote …
BACKGROUND: Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including …
Time for a neonatal-specific consensus definition for sepsis.
Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Wynn JL, et al. Among authors: wong hr. Pediatr Crit Care Med. 2014 Jul;15(6):523-8. doi: 10.1097/PCC.0000000000000157. Pediatr Crit Care Med. 2014. PMID: 24751791 Free PMC article. Review.
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. ...Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are cr …
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of …
Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis.
Slinko S, Piraino G, Hake PW, Ledford JR, O'Connor M, Lahni P, Solan PD, Wong HR, Zingarelli B. Slinko S, et al. Among authors: wong hr. Shock. 2014 Apr;41(4):292-300. doi: 10.1097/SHK.0000000000000127. Shock. 2014. PMID: 24430544 Free PMC article.
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular signal-regulated kinases 1 and 2 and nuclear factor kappaB activities in comparison to vehicle or single treatment protocols. Our data demonst …
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular si …
Pediatric sepsis: challenges and adjunctive therapies.
Hanna W, Wong HR. Hanna W, et al. Among authors: wong hr. Crit Care Clin. 2013 Apr;29(2):203-22. doi: 10.1016/j.ccc.2012.11.003. Epub 2013 Jan 3. Crit Care Clin. 2013. PMID: 23537672 Free PMC article. Review.
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the field. Future clinical studies should address long-term and functional outcomes as well as acute outcomes. Potential adjunctive therapie …
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the fie …
Heat shock protein induction protects human respiratory epithelium against nitric oxide-mediated cytotoxicity.
Wong HR, Ryan M, Menendez IY, Denenberg A, Wispé JR. Wong HR, et al. Shock. 1997 Sep;8(3):213-8. doi: 10.1097/00024382-199709000-00010. Shock. 1997. PMID: 9377169
Prior induction of HSPs was associated with protection against the NO-donors S-nitroso-N-acetyl penicillamine and 3-morpholinsydnonimine. Protection was evident as improved short term survival and improved ability of cells to recover and proliferate after exposure to NO. . …
Prior induction of HSPs was associated with protection against the NO-donors S-nitroso-N-acetyl penicillamine and 3-morpholinsydnonimine. Pr …
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