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The Role of hlb-Converting Bacteriophages in Staphylococcus aureus Host Adaption.
Rohmer C, Wolz C. Rohmer C, et al. Among authors: wolz c. Microb Physiol. 2021;31(2):109-122. doi: 10.1159/000516645. Epub 2021 Jun 14. Microb Physiol. 2021. PMID: 34126612 Free article. Review.
As an opportunistic pathogen of humans and animals, Staphylococcus aureus asymptomatically colonizes the nasal cavity but is also a leading cause of life-threatening acute and chronic infections. The evolution of S. aureus resulting from short- and long-term adaptation to …
As an opportunistic pathogen of humans and animals, Staphylococcus aureus asymptomatically colonizes the nasal cavity but is also a leading …
Intracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins.
Siegmund A, Afzal MA, Tetzlaff F, Keinhörster D, Gratani F, Paprotka K, Westermann M, Nietzsche S, Wolz C, Fraunholz M, Hübner CA, Löffler B, Tuchscherr L. Siegmund A, et al. Among authors: wolz c. Virulence. 2021 Dec;12(1):1186-1198. doi: 10.1080/21505594.2021.1910455. Virulence. 2021. PMID: 33843450 Free PMC article.
Endothelial cells can either be lysed by this pathogen or they serve as a niche for its intracellular long-term survival. Following phagocytosis, several vesicles such as phagosomes and autophagosomes, target intracellular S. aureus for elimination. ...In cell culture infe …
Endothelial cells can either be lysed by this pathogen or they serve as a niche for its intracellular long-term survival. Following p …
Regulatory and genomic plasticity of Staphylococcus aureus during persistent colonization and infection.
Goerke C, Wolz C. Goerke C, et al. Among authors: wolz c. Int J Med Microbiol. 2004 Sep;294(2-3):195-202. doi: 10.1016/j.ijmm.2004.06.013. Int J Med Microbiol. 2004. PMID: 15493830 Review.
Successful adaptation of the pathogen to the human host is achieved by regulatory mechanisms in the short term and by inheritable shifts in the population over the long term. ...S. aureus evolved over the millennia by adapting to the nasal environment and therefore …
Successful adaptation of the pathogen to the human host is achieved by regulatory mechanisms in the short term and by inheritable shi …
Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilization.
Goerke C, Matias y Papenberg S, Dasbach S, Dietz K, Ziebach R, Kahl BC, Wolz C. Goerke C, et al. Among authors: wolz c. J Infect Dis. 2004 Feb 15;189(4):724-34. doi: 10.1086/381502. Epub 2004 Jan 29. J Infect Dis. 2004. PMID: 14767828
Obviously, phage mobilization plays an important role in vivo. During long-term lung infection in patients with CF, the specific host response and/or the regular exposure to antibiotics exercises strong selective pressure on the pathogen. ...
Obviously, phage mobilization plays an important role in vivo. During long-term lung infection in patients with CF, the specific host …