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Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.
Wogulis M, Wright S, Cunningham D, Chilcote T, Powell K, Rydel RE. Wogulis M, et al. J Neurosci. 2005 Feb 2;25(5):1071-80. doi: 10.1523/JNEUROSCI.2381-04.2005. J Neurosci. 2005. PMID: 15689542 Free PMC article.
These findings bring into question the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide formazan assay (MTT assay) as a reporter of Abeta-mediated neuronal cell death and suggest that diffusible Abeta protofibrils and oligomers more likely mediate subtle al …
These findings bring into question the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide formazan assay (MTT assay) as …