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Diabetes mellitus does not alter mortality or hospitalisation risk in patients with newly diagnosed heart failure with preserved ejection fraction: Time to rethink pathophysiological models of disease progression.
Gierula J, Straw S, Cole CA, Lowry JE, Paton MF, McGinlay M, Witte KK, Grant PJ, Wheatcroft SB, Drozd M, Slater TA, Cubbon RM, Kearney MT. Gierula J, et al. Among authors: witte kk. Diab Vasc Dis Res. 2024 Mar-Apr;21(2):14791641231224241. doi: 10.1177/14791641231224241. Diab Vasc Dis Res. 2024. PMID: 38623877 Free PMC article.
INTRODUCTION: Type 2 diabetes is a common and adverse prognostic co-morbidity for patients with heart failure with reduced ejection fraction (HFrEF). The effect of diabetes on long-term outcomes for heart failure with preserved ejection fraction (HFpEF) is less established …
INTRODUCTION: Type 2 diabetes is a common and adverse prognostic co-morbidity for patients with heart failure with reduced ejection fraction …
Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).
Mullens W, Dauw J, Gustafsson F, Mebazaa A, Steffel J, Witte KK, Delgado V, Linde C, Vernooy K, Anker SD, Chioncel O, Milicic D, Hasenfuß G, Ponikowski P, von Bardeleben RS, Koehler F, Ruschitzka F, Damman K, Schwammenthal E, Testani JM, Zannad F, Böhm M, Cowie MR, Dickstein K, Jaarsma T, Filippatos G, Volterrani M, Thum T, Adamopoulos S, Cohen-Solal A, Moura B, Rakisheva A, Ristic A, Bayes-Genis A, Van Linthout S, Tocchetti CG, Savarese G, Skouri H, Adamo M, Amir O, Yilmaz MB, Simpson M, Tokmakova M, González A, Piepoli M, Seferovic P, Metra M, Coats AJS, Rosano GMC. Mullens W, et al. Among authors: witte kk. Eur J Heart Fail. 2024 Feb;26(2):483-501. doi: 10.1002/ejhf.3150. Epub 2024 Jan 25. Eur J Heart Fail. 2024. PMID: 38269474 Review.
A number of these devices have guideline recommendations and some have been shown to improve outcomes such as cardiac resynchronization therapy, implantable cardioverter-defibrillators and long-term mechanical support. For others, more evidence is still needed before large …
A number of these devices have guideline recommendations and some have been shown to improve outcomes such as cardiac resynchronization ther …
The CINCH-FMR postmarket registry: Real-world long-term outcomes with percutaneous mitral valve repair with the Carillon Mitral Contour System.
Yildiz M, Haude M, Sievert H, Fichtlscherer S, Lehmann R, Klein N, Witte K, Degen H, Pfeiffer D, Goldberg SL. Yildiz M, et al. Among authors: witte k. Cardiovasc Revasc Med. 2024 Mar;60:35-40. doi: 10.1016/j.carrev.2023.09.007. Epub 2023 Sep 23. Cardiovasc Revasc Med. 2024. PMID: 37838620
AIMS: The CINCH post-market registry is designed to evaluate immediate, mid-term and long-term outcomes from a post-approval study of the Carillon device evaluated in real-world practice. ...CONCLUSIONS: In this "real world" registry of the Carillon Mitral Contour S …
AIMS: The CINCH post-market registry is designed to evaluate immediate, mid-term and long-term outcomes from a post-approval s …
Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes.
Straw S, Gupta A, Johnson K, Cole CA, Kneizeh K, Gierula J, Kearney MT, Malkin CJ, Paton MF, Witte KK, Schlosshan D. Straw S, et al. Among authors: witte kk. Echo Res Pract. 2023 Mar 8;10(1):4. doi: 10.1186/s44156-023-00015-y. Echo Res Pract. 2023. PMID: 36882790 Free PMC article.
BACKGROUND: The prevalence, clinical characteristics, management and long-term outcomes of patients with atrial secondary mitral regurgitation (ASMR) are not well described. ...
BACKGROUND: The prevalence, clinical characteristics, management and long-term outcomes of patients with atrial secondary mitral regu …
No "carry-over" effects of tracking devices on return rate and parameters determining reproductive success in once and repeatedly tagged common swifts (Apus apus), a long-distance migratory bird.
Wellbrock AHJ, Witte K. Wellbrock AHJ, et al. Among authors: witte k. Mov Ecol. 2022 Dec 8;10(1):58. doi: 10.1186/s40462-022-00357-y. Mov Ecol. 2022. PMID: 36482483 Free PMC article.
So far, there are no studies investigating effects of repeatedly tagging on reproduction and life-history traits in individual migratory birds, especially in small birds. METHODS: We used long-term data of 85 tagged common swifts (Apus apus), a long-distance migratory bird …
So far, there are no studies investigating effects of repeatedly tagging on reproduction and life-history traits in individual migratory bir …
'Acute Heart Failure': Should We Abandon the Term Altogether?
Straw S, Napp A, Witte KK. Straw S, et al. Among authors: witte kk. Curr Heart Fail Rep. 2022 Dec;19(6):425-434. doi: 10.1007/s11897-022-00576-9. Epub 2022 Sep 27. Curr Heart Fail Rep. 2022. PMID: 36166184 Free PMC article. Review.
Current evidence supports four classes of medications proven to reduce cardiovascular mortality for those who have heart failure with a reduced ejection fraction, with recent trials suggesting worsening heart failure events are opportunities to optimise these therapies. Abandonin …
Current evidence supports four classes of medications proven to reduce cardiovascular mortality for those who have heart failure with a redu …
Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa?
Witte K, Sabat R, Witte-Händel E, Ghoreschi K, Wolk K. Witte K, et al. Int J Mol Sci. 2022 Aug 13;23(16):9057. doi: 10.3390/ijms23169057. Int J Mol Sci. 2022. PMID: 36012322 Free PMC article. Review.
Associated with numerous comorbidities including metabolic syndrome, HS is considered a systemic disease that severely impairs the quality of life and shortens life expectancy. Therapeutic options for HS are limited, comprising long-term antibiotic treatment, the surgical …
Associated with numerous comorbidities including metabolic syndrome, HS is considered a systemic disease that severely impairs the quality o …
Surgical Techniques and Outcomes in Patients With Intra-Cardiac Abscesses Complicating Infective Endocarditis.
Straw S, Baig MW, Mishra V, Gillott R, Witte KK, Van Doorn C, Ferrara A, Javangula K, Sandoe JAT. Straw S, et al. Among authors: witte kk. Front Cardiovasc Med. 2022 May 31;9:875870. doi: 10.3389/fcvm.2022.875870. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35711342 Free PMC article.
The primary outcome was 30-day mortality in operated patients and secondary outcomes were freedom from re-infection, re-operation and long-term mortality comparing those patients with aortic root abscess who underwent aortic valve replacement (AVR) and those who received a …
The primary outcome was 30-day mortality in operated patients and secondary outcomes were freedom from re-infection, re-operation and long- …
Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes.
Chowdhary A, Jex N, Thirunavukarasu S, MacCannell A, Haywood N, Almutairi A, Athithan L, Jain M, Craven T, Das A, Sharrack N, Saunderson CED, Sengupta A, Roberts L, Swoboda P, Cubbon R, Witte K, Greenwood J, Plein S, Levelt E. Chowdhary A, et al. Among authors: witte k. Cardiol Res Pract. 2022 Feb 8;2022:6401180. doi: 10.1155/2022/6401180. eCollection 2022. Cardiol Res Pract. 2022. PMID: 35178251 Free PMC article.
BACKGROUND: T2D increases the risk of heart failure (HF) and cardiovascular mortality. The long-term impact of T2D on cardiac phenotype in the absence of cardiovascular disease and other clinical events is unknown. ...
BACKGROUND: T2D increases the risk of heart failure (HF) and cardiovascular mortality. The long-term impact of T2D on cardiac phenoty …
Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation.
Claxton L, Simmonds M, Beresford L, Cubbon R, Dayer M, Gottlieb SS, Hartshorne-Evans N, Kilroy B, Llewellyn A, Rothery C, Sharif S, Tierney JF, Witte KK, Wright K, Stewart LA. Claxton L, et al. Among authors: witte kk. Health Technol Assess. 2022 Jan;26(4):1-128. doi: 10.3310/KVOU6959. Health Technol Assess. 2022. PMID: 35076012 Free article.
Meta-analysis suggested a possible benefit of coenzyme Q10 on all-cause mortality (seven trials, 1371 participants; relative risk 0.68, 95% confidence interval 0.45 to 1.03). The results for short-term functional outcomes were more modest or unclear. There was no indicatio …
Meta-analysis suggested a possible benefit of coenzyme Q10 on all-cause mortality (seven trials, 1371 participants; relative risk 0.68, 95% …
56 results