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Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants.
O'Connor KM, Das AB, Winterbourn CC, Hampton MB. O'Connor KM, et al. Among authors: winterbourn cc. J Biol Chem. 2020 Jun 5;295(23):7839-7848. doi: 10.1074/jbc.RA120.013092. Epub 2020 Apr 20. J Biol Chem. 2020. PMID: 32312750 Free PMC article.
Excessive generation of oxidants by immune cells results in acute tissue damage. One mechanism by which oxidant exposure could have long-term effects is modulation of epigenetic pathways. We hypothesized that methylation of newly synthesized DNA in proliferating cells can …
Excessive generation of oxidants by immune cells results in acute tissue damage. One mechanism by which oxidant exposure could have long- …
High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction.
Nedoboy PE, Morgan PE, Mocatta TJ, Richards AM, Winterbourn CC, Davies MJ. Nedoboy PE, et al. Among authors: winterbourn cc. Free Radic Res. 2014 Oct;48(10):1256-66. doi: 10.3109/10715762.2014.947286. Free Radic Res. 2014. PMID: 25050609
In this retrospective study, we examined whether elevated plasma MPO and SCN(-) levels increased thiol oxidation as a result of increased HOSCN formation, and impacted on long-term survival in 176 subjects (74 non-smokers, 46 smokers, and 56 previous smokers) hospitalized …
In this retrospective study, we examined whether elevated plasma MPO and SCN(-) levels increased thiol oxidation as a result of increased HO …
Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep.
Fraser M, Bennet L, Van Zijl PL, Mocatta TJ, Williams CE, Gluckman PD, Winterbourn CC, Gunn AJ. Fraser M, et al. Among authors: winterbourn cc. J Neurochem. 2008 Jun 1;105(6):2214-23. doi: 10.1111/j.1471-4159.2008.05313.x. J Neurochem. 2008. PMID: 18315562 Free article.
It is widely hypothesized that accumulation of excitatory amino acids, and oxygen free radicals during or after exposure to hypoxia-ischemia play a pivotal role in preterm periventricular white matter injury; however, there is limited evidence in the intact brain. In preterm feta …
It is widely hypothesized that accumulation of excitatory amino acids, and oxygen free radicals during or after exposure to hypoxia-ischemia …
Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction.
Mocatta TJ, Pilbrow AP, Cameron VA, Senthilmohan R, Frampton CM, Richards AM, Winterbourn CC. Mocatta TJ, et al. Among authors: winterbourn cc. J Am Coll Cardiol. 2007 May 22;49(20):1993-2000. doi: 10.1016/j.jacc.2007.02.040. Epub 2007 May 4. J Am Coll Cardiol. 2007. PMID: 17512353 Free article.
CONCLUSIONS: Myeloperoxidase and protein carbonyl levels are elevated in plasma after acute MI, apparently via independent mechanisms. High MPO is a risk factor for long-term mortality and adds prognostic value to LVEF and plasma NT-proBNP measurements....
CONCLUSIONS: Myeloperoxidase and protein carbonyl levels are elevated in plasma after acute MI, apparently via independent mechanisms. High …
The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn.
Ellison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, Inder TE. Ellison VJ, et al. Among authors: winterbourn cc. Pediatr Res. 2005 Feb;57(2):282-6. doi: 10.1203/01.PDR.0000148286.53572.95. Epub 2004 Dec 7. Pediatr Res. 2005. PMID: 15585689
Preterm infants underwent advanced quantitative volumetric magnetic resonance imaging using a 1.5-Tesla scanner at term equivalent. One hundred forty-six infants were enrolled and 190 CSF and 42 plasma samples obtained. ...
Preterm infants underwent advanced quantitative volumetric magnetic resonance imaging using a 1.5-Tesla scanner at term equivalent. O …
The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma.
Mocatta TJ, Winterbourn CC, Inder TE, Darlow BA. Mocatta TJ, et al. Among authors: winterbourn cc. Free Radic Res. 2004 Feb;38(2):185-91. doi: 10.1080/10715760310001646048. Free Radic Res. 2004. PMID: 15104212
There are many potential sources of reactive oxidants around the time of birth and pre-term infants are considered to be particularly vulnerable to oxidative injury. ...In contrast, MDA concentrations were higher in the very pre-term (<32 weeks gestation) …
There are many potential sources of reactive oxidants around the time of birth and pre-term infants are considered to be parti …
The effect of hypochlorous acid on the expression of adhesion molecules and activation of NF-kappaB in cultured human endothelial cells.
Pullar JM, Winterbourn CC, Vissers MC. Pullar JM, et al. Among authors: winterbourn cc. Antioxid Redox Signal. 2002 Feb;4(1):5-15. doi: 10.1089/152308602753625807. Antioxid Redox Signal. 2002. PMID: 11970838
However, the dose of HOCl required for this effect resulted in considerable longer-term toxicity to the cells. Treatment of HUVEC with sublethal doses of HOCl had no effect on NF-kappaB activation, neutrophil adhesion, or the surface expression of E-selectin, ICAM-1, or P- …
However, the dose of HOCl required for this effect resulted in considerable longer-term toxicity to the cells. Treatment of HUVEC wit …
Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation.
Winterbourn CC, Chan T, Buss IH, Inder TE, Mogridge N, Darlow BA. Winterbourn CC, et al. Pediatr Res. 2000 Jul;48(1):84-90. doi: 10.1203/00006450-200007000-00015. Pediatr Res. 2000. PMID: 10879804 Clinical Trial.
Respiratory outcome was assessed as oxygen requirement at 28 d of age or 36 wk postmenstrual age and as number of days on oxygen. Protein carbonyl concentrations in very low birth weight infants were significantly higher than for adults but lower than for cord blood from …
Respiratory outcome was assessed as oxygen requirement at 28 d of age or 36 wk postmenstrual age and as number of days on oxygen. Protein ca …
The correlation of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant.
Inder TE, Darlow BA, Sluis KB, Winterbourn CC, Graham P, Sanderson KJ, Taylor BJ. Inder TE, et al. Among authors: winterbourn cc. Acta Paediatr. 1996 Sep;85(9):1116-22. doi: 10.1111/j.1651-2227.1996.tb14228.x. Acta Paediatr. 1996. PMID: 8888929
These results substantiate previously reported preliminary observations and support the hypothesis that oxidative injury, particularly within the first 7 days of life, is associated with the development of the long-term complications of the pre-term infant. MDA-TBA …
These results substantiate previously reported preliminary observations and support the hypothesis that oxidative injury, particularly withi …
Selenium and glutathione peroxidase levels in premature infants in a low selenium community (Christchurch, New Zealand).
Sluis KB, Darlow BA, George PM, Mogridge N, Dolamore BA, Winterbourn CC. Sluis KB, et al. Among authors: winterbourn cc. Pediatr Res. 1992 Aug;32(2):189-94. doi: 10.1203/00006450-199208000-00013. Pediatr Res. 1992. PMID: 1508608
Premature infants had levels significantly lower than those in cord blood from term infants, but their levels were not different from those of term infants admitted to the unit. ...
Premature infants had levels significantly lower than those in cord blood from term infants, but their levels were not different from …
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