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Page 1
Refining the Pediatric Multiple Organ Dysfunction Syndrome.
Weiss SL, Carcillo JA, Leclerc F, Leteurtre S, Schlapbach LJ, Tissieres P, Wynn JL, Lacroix J; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Weiss SL, et al. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S13-S22. doi: 10.1542/peds.2021-052888C. Pediatrics. 2022. PMID: 34970671 Free PMC article.
Since its introduction into the medical literature in the 1970s, the term multiple organ dysfunction syndrome (or some variant) has been applied broadly to any patient with >1 concurrent organ dysfunction. However, the epidemiology, mechanisms, time course, and outcomes …
Since its introduction into the medical literature in the 1970s, the term multiple organ dysfunction syndrome (or some variant) has b …
Surfactant therapy for acute lung injury and acute respiratory distress syndrome.
Raghavendran K, Willson D, Notter RH. Raghavendran K, et al. Among authors: willson d. Crit Care Clin. 2011 Jul;27(3):525-59. doi: 10.1016/j.ccc.2011.04.005. Crit Care Clin. 2011. PMID: 21742216 Free PMC article. Review.
This article examines exogenous lung surfactant replacement therapy and its usefulness in mitigating clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Surfactant therapy is beneficial in term infants with pneumonia and meconium aspiration …
This article examines exogenous lung surfactant replacement therapy and its usefulness in mitigating clinical acute lung injury (ALI) and th …
The outcomes of children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference.
Quasney MW, López-Fernández YM, Santschi M, Watson RS; Pediatric Acute Lung Injury Consensus Conference Group. Quasney MW, et al. Pediatr Crit Care Med. 2015 Jun;16(5 Suppl 1):S118-31. doi: 10.1097/PCC.0000000000000438. Pediatr Crit Care Med. 2015. PMID: 26035362
Little knowledge of long-term outcomes exists in children who survive pediatric acute respiratory distress syndrome. Characterization of the longer term consequences of pediatric acute respiratory distress syndrome in children is vital to help identify opportunities …
Little knowledge of long-term outcomes exists in children who survive pediatric acute respiratory distress syndrome. Characterization …
Development of Persistent Respiratory Morbidity in Previously Healthy Children After Acute Respiratory Failure.
Keim G, Yehya N, Spear D, Hall MW, Loftis LL, Alten JA, McArthur J, Patwari PP, Freishtat RJ, Willson DF, Straumanis JP, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Keim G, et al. Among authors: willson df. Crit Care Med. 2020 Aug;48(8):1120-1128. doi: 10.1097/CCM.0000000000004380. Crit Care Med. 2020. PMID: 32697481 Free PMC article.
OBJECTIVES: Acute respiratory failure is a common reason for admission to PICUs. Short- and long-term effects on pulmonary health in previously healthy children after acute respiratory failure requiring mechanical ventilation are unknown. ...
OBJECTIVES: Acute respiratory failure is a common reason for admission to PICUs. Short- and long-term effects on pulmonary health in …
The Adult Calfactant in Acute Respiratory Distress Syndrome Trial.
Willson DF, Truwit JD, Conaway MR, Traul CS, Egan EE. Willson DF, et al. Chest. 2015 Aug;148(2):356-364. doi: 10.1378/chest.14-1139. Chest. 2015. PMID: 25855884 Clinical Trial.
CONCLUSIONS: Administration of calfactant was not associated with improved oxygenation or longer-term benefits relative to placebo in this randomized, controlled, and masked trial. ...
CONCLUSIONS: Administration of calfactant was not associated with improved oxygenation or longer-term benefits relative to placebo in …
Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus.
Thomas NJ, DiAngelo S, Hess JC, Fan R, Ball MW, Geskey JM, Willson DF, Floros J. Thomas NJ, et al. Among authors: willson df. Pediatr Res. 2009 Jul;66(1):70-3. doi: 10.1203/PDR.0b013e3181a1d768. Pediatr Res. 2009. PMID: 19287351 Free PMC article.
Further study is required to determine whether these variants can be used to target a high-risk patient population in clinical trials aimed at reducing either the symptoms of acute infection or long-term pulmonary sequelae....
Further study is required to determine whether these variants can be used to target a high-risk patient population in clinical trials aimed …
The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.
Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Burr J, Willson DF, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Carcillo JA, et al. Among authors: willson df. Pediatr Crit Care Med. 2012 Mar;13(2):165-73. doi: 10.1097/PCC.0b013e31823896ae. Pediatr Crit Care Med. 2012. PMID: 22079954 Free PMC article. Clinical Trial.
OBJECTIVES: Nosocomial infection/sepsis occurs in up to 40% of children requiring long-term intensive care. Zinc, selenium, glutamine, metoclopramide (a prolactin secretalogue), and/or whey protein supplementation have been effective in reducing infection and sepsis in oth …
OBJECTIVES: Nosocomial infection/sepsis occurs in up to 40% of children requiring long-term intensive care. Zinc, selenium, glutamine …
Acute lung injury in children--kids really aren't just "little adults".
Thomas NJ, Jouvet P, Willson D. Thomas NJ, et al. Among authors: willson d. Pediatr Crit Care Med. 2013 May;14(4):429-32. doi: 10.1097/PCC.0b013e31827456aa. Pediatr Crit Care Med. 2013. PMID: 23439464
RESULTS: The Pediatric Acute Lung Injury Consensus Conference will aim for consensus development on the following topics related to pediatric acute lung injury: 1) definition, incidence, and epidemiology; 2) comorbidities and severity; 3) ventilatory support; 4) pulmonary-specifi …
RESULTS: The Pediatric Acute Lung Injury Consensus Conference will aim for consensus development on the following topics related to pediatri …
Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial.
Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA; Pediatric Acute Lung Injury and Sepsis Investigators. Willson DF, et al. JAMA. 2005 Jan 26;293(4):470-6. doi: 10.1001/jama.293.4.470. JAMA. 2005. PMID: 15671432 Clinical Trial.
More patients in the placebo group did not respond to conventional mechanical ventilation. There were no differences in long-term complications. CONCLUSIONS: Calfactant acutely improved oxygenation and significantly decreased mortality in infants, children, and adolescents …
More patients in the placebo group did not respond to conventional mechanical ventilation. There were no differences in long-term com …
Calf's lung surfactant extract in acute hypoxemic respiratory failure in children.
Willson DF, Jiao JH, Bauman LA, Zaritsky A, Craft H, Dockery K, Conrad D, Dalton H. Willson DF, et al. Crit Care Med. 1996 Aug;24(8):1316-22. doi: 10.1097/00003246-199608000-00008. Crit Care Med. 1996. PMID: 8706485 Clinical Trial.
OBJECTIVE: Open-label trial of the safety and short-term efficacy of calf's lung surfactant in pediatric respiratory failure. ...
OBJECTIVE: Open-label trial of the safety and short-term efficacy of calf's lung surfactant in pediatric respiratory failure. ...