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Vigabatrin: 2008 update.
Willmore LJ, Abelson MB, Ben-Menachem E, Pellock JM, Shields WD. Willmore LJ, et al. Epilepsia. 2009 Feb;50(2):163-73. doi: 10.1111/j.1528-1167.2008.01988.x. Epilepsia. 2009. PMID: 19230067 Free article. Review.
In cases where complete spasm cessation, seizure control, or meaningful improvement is achieved within 12 weeks, continued treatment with VGB is warranted; subsequent periodic monitoring for the peripheral VFD is necessary and should be used to mitigate the risk of the defect. Th …
In cases where complete spasm cessation, seizure control, or meaningful improvement is achieved within 12 weeks, continued treatment with VG …
Kindling phenomena induced by the repeated short-term high potassium stimuli in the ventral hippocampus of rats: on-line monitoring of extracellular glutamate overflow.
Ueda Y, Doi T, Tokumaru J, Mitsuyama Y, Willmore LJ. Ueda Y, et al. Among authors: willmore lj. Exp Brain Res. 2000 Nov;135(2):199-203. doi: 10.1007/s002210000509. Exp Brain Res. 2000. PMID: 11131504
The augmentation of glutamate release and the prolongation of spike discharge with epileptic convulsions are completely Ca++ dependent. These data show that repeated short-term increases in extracellular glutamate levels results in the enhancement of excitatory neuronal sy …
The augmentation of glutamate release and the prolongation of spike discharge with epileptic convulsions are completely Ca++ dependent. Thes …
Efficacy and safety of zonisamide: results of a multicenter study.
Leppik IE, Willmore LJ, Homan RW, Fromm G, Oommen KJ, Penry JK, Sackellares JC, Smith DB, Lesser RP, Wallace JD, et al. Leppik IE, et al. Among authors: willmore lj. Epilepsy Res. 1993 Feb;14(2):165-73. doi: 10.1016/0920-1211(93)90021-x. Epilepsy Res. 1993. PMID: 8453952 Clinical Trial.
Persons completing the efficacy study successfully were eligible for a long-term safety study; 113 entered this study. Adverse effects involved principally the CNS and were similar to those seen with other antiepileptic drugs. ...
Persons completing the efficacy study successfully were eligible for a long-term safety study; 113 entered this study. Adverse effect …
Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography.
Perchalski RJ, Bruni J, Wilder BJ, Willmore LJ. Perchalski RJ, et al. Among authors: willmore lj. J Chromatogr. 1979 Jun 11;163(2):187-93. doi: 10.1016/s0378-4347(00)81462-0. J Chromatogr. 1979. PMID: 541370
The extraction is rapid and generally applicable to plasma and urine samples that are to be analyzed by reversed-phase chromatography. Short- and long-term reproducibility studies show less than 4% relative standard deviation for replicate determinations for all drugs. ...
The extraction is rapid and generally applicable to plasma and urine samples that are to be analyzed by reversed-phase chromatography. Short …
Clinical efficacy of valproic acid in relation to plasma levels.
Bruni J, Wilder BJ, Willmore LJ, Villarreal HJ, Thomas M, Crawford LE. Bruni J, et al. Among authors: willmore lj. Can J Neurol Sci. 1978 Nov;5(4):385-7. doi: 10.1017/s0317167100024148. Can J Neurol Sci. 1978. PMID: 105796
Excellent clinical response was observed in the treatment of absence and myoclonic seizures. Twenty-two patients continued in a long term study have maintained the same degree of seizure control as observed at the time of optimal control....
Excellent clinical response was observed in the treatment of absence and myoclonic seizures. Twenty-two patients continued in a long term …