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Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume.
Otmani A, Jóhannesson G, Brautaset R, Tribble JR, Williams PA. Otmani A, et al. Among authors: williams pa. Acta Neuropathol Commun. 2024 Mar 1;12(1):37. doi: 10.1186/s40478-024-01724-z. Acta Neuropathol Commun. 2024. PMID: 38429841 Free PMC article.
Leber's hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for LHON. Oral nicotin …
Leber's hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell …
The experience of using home automation by individuals with disability.
Cleland J, Hutchinson C, Williams PAH, Manuel K, Laver K. Cleland J, et al. Among authors: williams pah. Disabil Rehabil Assist Technol. 2023 Nov 29:1-8. doi: 10.1080/17483107.2023.2288391. Online ahead of print. Disabil Rehabil Assist Technol. 2023. PMID: 38019056
Purpose: People with disability often require long-term support within the home. Advances in technology have made home automation more readily available to support people living with disability. ...The aim of this study was to explore the experience of individuals living w …
Purpose: People with disability often require long-term support within the home. Advances in technology have made home automation mor …
A scoping review to explore the health, social and economic outcomes of home automation for people with disability.
Cleland J, Hutchinson C, Williams PAH, Manuel K, Laver K. Cleland J, et al. Among authors: williams pah. Disabil Rehabil Assist Technol. 2024 May;19(4):1446-1453. doi: 10.1080/17483107.2023.2196308. Epub 2023 Apr 3. Disabil Rehabil Assist Technol. 2024. PMID: 37012673 Review.
PURPOSE: People with disability often require long-term care. Long-term care is changing with the availability and advances in cost and function of technologies, such as home automation. ...
PURPOSE: People with disability often require long-term care. Long-term care is changing with the availability and advances in …
Home Automation for Adults With Disability Following an Injury: Protocol for a Social Return on Investment Study.
Cleland J, Hutchinson C, Williams PAH, Manuel K, Laver K. Cleland J, et al. Among authors: williams pah. JMIR Res Protoc. 2022 Dec 21;11(12):e42493. doi: 10.2196/42493. JMIR Res Protoc. 2022. PMID: 36542464 Free PMC article.
BACKGROUND: People with disability following a serious injury require long-term care. The most common injuries resulting in long-term disability are spinal cord and acquired brain injuries. While the long-term effects are difficult to predict and will vary be …
BACKGROUND: People with disability following a serious injury require long-term care. The most common injuries resulting in long-t …
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
De Moraes CG, John SWM, Williams PA, Blumberg DM, Cioffi GA, Liebmann JM. De Moraes CG, et al. Among authors: williams pa. JAMA Ophthalmol. 2022 Jan 1;140(1):11-18. doi: 10.1001/jamaophthalmol.2021.4576. JAMA Ophthalmol. 2022. PMID: 34792559 Free PMC article.
CONCLUSIONS AND RELEVANCE: A combination of nicotinamide and pyruvate yielded significant short-term improvement in visual function, supporting prior experimental research suggesting a role for these agents in neuroprotection for individuals with glaucoma and confirming th …
CONCLUSIONS AND RELEVANCE: A combination of nicotinamide and pyruvate yielded significant short-term improvement in visual function, …
Moving beyond More of the Same, but Better - How Campuses of Care Can Transform Long-Term Care.
Morton-Chang F, Williams PA. Morton-Chang F, et al. Among authors: williams pa. Healthc Pap. 2021 Sep;20(1):59-65. doi: 10.12927/hcpap.2021.26639. Healthc Pap. 2021. PMID: 34792462
As we look forward, it is imperative to consider options not just for improving residential long-term care but also for integrating it into broader continuums of health and social care, where people can receive supports and services in the most appropriate setting. ...
As we look forward, it is imperative to consider options not just for improving residential long-term care but also for integrating i …
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.
Tribble JR, Otmani A, Sun S, Ellis SA, Cimaglia G, Vohra R, Jöe M, Lardner E, Venkataraman AP, Domínguez-Vicent A, Kokkali E, Rho S, Jóhannesson G, Burgess RW, Fuerst PG, Brautaset R, Kolko M, Morgan JE, Crowston JG, Votruba M, Williams PA. Tribble JR, et al. Among authors: williams pa. Redox Biol. 2021 Jul;43:101988. doi: 10.1016/j.redox.2021.101988. Epub 2021 Apr 24. Redox Biol. 2021. PMID: 33932867 Free PMC article.
These data support continued determination of the utility of long-term nicotinamide treatment as a neuroprotective therapy for human glaucoma....
These data support continued determination of the utility of long-term nicotinamide treatment as a neuroprotective therapy for human …
Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.
Hui F, Tang J, Williams PA, McGuinness MB, Hadoux X, Casson RJ, Coote M, Trounce IA, Martin KR, van Wijngaarden P, Crowston JG. Hui F, et al. Among authors: williams pa. Clin Exp Ophthalmol. 2020 Sep;48(7):903-914. doi: 10.1111/ceo.13818. Epub 2020 Jul 28. Clin Exp Ophthalmol. 2020. PMID: 32721104 Clinical Trial.
CONCLUSIONS: Nicotinamide supplementation can improve inner retinal function in glaucoma. Further studies underway to elucidate the effects of long-term nicotinamide supplementation....
CONCLUSIONS: Nicotinamide supplementation can improve inner retinal function in glaucoma. Further studies underway to elucidate the effects …
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.
Tribble JR, Harder JM, Williams PA, John SWM. Tribble JR, et al. Among authors: williams pa. Mol Brain. 2020 May 25;13(1):81. doi: 10.1186/s13041-020-00603-7. Mol Brain. 2020. PMID: 32450896 Free PMC article.
However, the exact molecular identity / transcriptomic profile of microglia following ocular hypertensive insults is unknown. To elucidate the molecular identity of microglia after long-term exposure to ocular hypertension, we used a mouse model of glaucoma (DBA/2 J). ...
However, the exact molecular identity / transcriptomic profile of microglia following ocular hypertensive insults is unknown. To elucidate t …
21 results