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Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections.
Behrends V, Ryall B, Zlosnik JE, Speert DP, Bundy JG, Williams HD. Behrends V, et al. Among authors: williams hd. Environ Microbiol. 2013 Feb;15(2):398-408. doi: 10.1111/j.1462-2920.2012.02840.x. Epub 2012 Aug 8. Environ Microbiol. 2013. PMID: 22882524
Understanding how this opportunistic pathogen adapts to the CF lung during chronic infections is important to increase the efficacy of treatment and is likely to increase insight into other long-term infections. Previous studies of P. aeruginosa adaptation and divergence i …
Understanding how this opportunistic pathogen adapts to the CF lung during chronic infections is important to increase the efficacy of treat …
Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro.
Hingley-Wilson SM, Lougheed KE, Ferguson K, Leiva S, Williams HD. Hingley-Wilson SM, et al. Among authors: williams hd. Tuberculosis (Edinb). 2010 Jul;90(4):236-44. doi: 10.1016/j.tube.2010.03.013. Epub 2010 Jun 11. Tuberculosis (Edinb). 2010. PMID: 20541977 Free PMC article.
Although the majority of usp genes are highly induced in hypoxic conditions, mutation did not affect the long term survival of Mtb under these conditions, or in response to a range of stress conditions chosen to represent the environmental onslaughts experienced by the bac …
Although the majority of usp genes are highly induced in hypoxic conditions, mutation did not affect the long term survival of Mtb un …
Adaptation of Mycobacterium smegmatis to stationary phase.
Smeulders MJ, Keer J, Speight RA, Williams HD. Smeulders MJ, et al. Among authors: williams hd. J Bacteriol. 1999 Jan;181(1):270-83. doi: 10.1128/JB.181.1.270-283.1999. J Bacteriol. 1999. PMID: 9864340 Free PMC article.
Colony morphology variants accumulated in stationary-phase cultures. A flat colony variant was seen in 75% of all long-term-stationary-phase cultures and frequently took over the whole population. ...
Colony morphology variants accumulated in stationary-phase cultures. A flat colony variant was seen in 75% of all long-term-stationar …
Adaptation to nutrient starvation in Rhizobium leguminosarum bv. phaseoli: analysis of survival, stress resistance, and changes in macromolecular synthesis during entry to and exit from stationary phase.
Thorne SH, Williams HD. Thorne SH, et al. Among authors: williams hd. J Bacteriol. 1997 Nov;179(22):6894-901. doi: 10.1128/jb.179.22.6894-6901.1997. J Bacteriol. 1997. PMID: 9371432 Free PMC article.
Upon carbon starvation, R. leguminosarum cells were found to undergo reductive cell division. During this period, they acquired the potential for long-term starvation-survival, levels of protein, DNA, and RNA synthesis were decreased to base levels, and pool mRNA was stabi …
Upon carbon starvation, R. leguminosarum cells were found to undergo reductive cell division. During this period, they acquired the potentia …