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The effectiveness of heat preparation and alleviation strategies for cognitive performance: A systematic review.
Donnan KJ, Williams EL, Bargh MJ. Donnan KJ, et al. Among authors: williams el. Temperature (Austin). 2023 Jan 4;10(4):404-433. doi: 10.1080/23328940.2022.2157645. eCollection 2023. Temperature (Austin). 2023. PMID: 38130656 Free PMC article. Review.
Interventions were categorised into chronic (i.e. acclimation/acclimatisation) and acute strategies (i.e. hydration, cooling, supplementation, psychological). The results indicate that medium-term consecutive heat acclimation may mitigate some cognitive deficits under heat …
Interventions were categorised into chronic (i.e. acclimation/acclimatisation) and acute strategies (i.e. hydration, cooling, supplementatio …
The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy.
Kowalka AM, Alexiadou K, Cuenco J, Clarke RE, Minnion J, Williams EL, Bech P, Purkayastha S, Ahmed AR, Takats Z, Whitwell HJ, Romero MG, Bloom SR, Camuzeaux S, Lewis MR, Khoo B, Tan TM. Kowalka AM, et al. Among authors: williams el. Clin Endocrinol (Oxf). 2023 Sep;99(3):272-284. doi: 10.1111/cen.14846. Epub 2022 Nov 28. Clin Endocrinol (Oxf). 2023. PMID: 36345253 Free PMC article.
At 1 year after surgery, RYGB, but not SG, is associated with increased postprandial secretion of PYY(1-36) and PYY(3-36) , which may account for long-term differences in efficacy and adverse effects between the two types of surgery....
At 1 year after surgery, RYGB, but not SG, is associated with increased postprandial secretion of PYY(1-36) and PYY(3-36) , which may accoun …
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
Moreno-Vicente J, Willoughby JE, Taylor MC, Booth SG, English VL, Williams EL, Penfold CA, Mockridge CI, Inzhelevskaya T, Kim J, Chan HTC, Cragg MS, Gray JC, Beers SA. Moreno-Vicente J, et al. Among authors: williams el. J Immunother Cancer. 2022 Jan;10(1):e003735. doi: 10.1136/jitc-2021-003735. J Immunother Cancer. 2022. PMID: 35017153 Free PMC article.
In the context of an immunologically 'hot' tumor however, both low-engaging and Fc-null mAbs induced long-term antitumor immunity in MC38-bearing mice. Finally, a similar anti-PD-1 isotype hierarchy was demonstrated in the less responsive 'cold' 9464D neuroblastoma model, …
In the context of an immunologically 'hot' tumor however, both low-engaging and Fc-null mAbs induced long-term antitumor immunity in …
Salt supplementation in the management of orthostatic intolerance: Vasovagal syncope and postural orthostatic tachycardia syndrome.
Williams EL, Raj SR, Schondorf R, Shen WK, Wieling W, Claydon VE. Williams EL, et al. Auton Neurosci. 2022 Jan;237:102906. doi: 10.1016/j.autneu.2021.102906. Epub 2021 Nov 11. Auton Neurosci. 2022. PMID: 34823150 Free article. Review.
Accordingly, we reviewed the evidence for the use of salt supplementation to reduce susceptibility to syncope or presyncope in patients with VVS and POTS. We found that short-term (~3 months) salt supplementation improves susceptibility to VVS and associated symptoms, with …
Accordingly, we reviewed the evidence for the use of salt supplementation to reduce susceptibility to syncope or presyncope in patients with …
The relationship between vitamin D status, intake and exercise performance in UK University-level athletes and healthy inactive controls.
Wilson-Barnes SL, Hunt JEA, Mendis J, Williams EL, King D, Roberts H, Lanham-New SA, Manders RJF. Wilson-Barnes SL, et al. Among authors: williams el. PLoS One. 2021 Apr 2;16(4):e0249671. doi: 10.1371/journal.pone.0249671. eCollection 2021. PLoS One. 2021. PMID: 33798240 Free PMC article.
Notably, 22% of the subjects recruited were vitD deficient during the spring term only (<25nmol/L, n 9). Subjects with 'insufficient' vitD status (<50nmol/L) elicited significantly lower CMJ when contrasted to the vitD 'sufficient' (>50nmol/l) group (p = 0.055) an …
Notably, 22% of the subjects recruited were vitD deficient during the spring term only (<25nmol/L, n 9). Subjects with 'insufficie …
Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma model.
Williams EL, Dunn SN, James S, Johnson PW, Cragg MS, Glennie MJ, Gray JC. Williams EL, et al. Clin Cancer Res. 2013 Jul 1;19(13):3545-55. doi: 10.1158/1078-0432.CCR-12-3226. Epub 2013 May 6. Clin Cancer Res. 2013. PMID: 23649004 Free PMC article.
RESULTS: In the Neuro2a model, treatment of established tumor with anti-4-1BB, anti-CD40, or anti-CTLA-4 mAb results in tumor regression and long-term survival in 40% to 60% of mice. This is dependent on natural killer (NK) and CD8(+) T cells and is associated with tumor C …
RESULTS: In the Neuro2a model, treatment of established tumor with anti-4-1BB, anti-CD40, or anti-CTLA-4 mAb results in tumor regression and …
Effects of short-term glucagon administration on gluconeogenic enzymes in the liver of midlactation dairy cows.
Williams EL, Rodriguez SM, Beitz DC, Donkin SS. Williams EL, et al. J Dairy Sci. 2006 Feb;89(2):693-703. doi: 10.3168/jds.S0022-0302(06)72132-4. J Dairy Sci. 2006. PMID: 16428638 Free article.
The objective of this study was to determine the effect of short-term administration of glucagon on expression of gluconeogenic enzymes in lactating dairy cattle. ...
The objective of this study was to determine the effect of short-term administration of glucagon on expression of gluconeogenic enzym …
Structural organization, mapping, characterization and evolutionary relationships of CDKN2 gene family members in Xiphophorus fishes.
Kazianis S, Khanolkar VA, Nairn RS, Rains JD, Trono D, Garcia R, Williams EL, Walter RB. Kazianis S, et al. Among authors: williams el. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul;138(3):291-9. doi: 10.1016/j.cca.2004.08.003. Comp Biochem Physiol C Toxicol Pharmacol. 2004. PMID: 15533787
We have investigated the status of the gene family in the southern platyfish X. maculatus. Xiphophorus harbors at least two such loci, which we now term CDKN2A/B and CDKN2D. Both loci map to Xiphophorus linkage group 5, a genomic area that has long been known to harbor the …
We have investigated the status of the gene family in the southern platyfish X. maculatus. Xiphophorus harbors at least two such loci, which …