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Association of New-Onset Atrial Fibrillation With All-Cause Mortality in COVID-19 Patients.
Zaheer K, Goncalves B, Ramalingam A, Rabbani NUA, Sayyed R, Nawab A, Puri R, Williams CJ, Mansoor K. Zaheer K, et al. Among authors: williams cj. Cureus. 2023 Dec 1;15(12):e49785. doi: 10.7759/cureus.49785. eCollection 2023 Dec. Cureus. 2023. PMID: 38058521 Free PMC article.
Our findings underscore the importance of recognizing and managing arrhythmias in COVID-19 and call for further research on the mechanisms and long-term effects of these cardiac complications in the context of the pandemic. ...
Our findings underscore the importance of recognizing and managing arrhythmias in COVID-19 and call for further research on the mechanisms a …
Sample size determination for point-of-care COVID-19 diagnostic tests: a Bayesian approach.
Williamson SF, Williams CJ, Lendrem BC, Wilson KJ. Williamson SF, et al. Among authors: williams cj. Diagn Progn Res. 2023 Aug 18;7(1):17. doi: 10.1186/s41512-023-00153-1. Diagn Progn Res. 2023. PMID: 37596684 Free PMC article.
It has highlighted that the trade-off between lab study sample size and diagnostic accuracy study sample size should be carefully considered, since establishing an adequate lab sample size can bring longer-term gains. Although emphasis is on its use in the COVID-19 pandemi …
It has highlighted that the trade-off between lab study sample size and diagnostic accuracy study sample size should be carefully considered …
Patient Self-Testing of Kidney Function at Home, a Prospective Clinical Feasibility Study in Kidney Transplant Recipients.
Murray JS, Williams CJ, Lendrem C, Smithson J, Allinson C, Robinson J, Walker A, Winter A, Simpson AJ, Newton J, Wroe C, Jones WS. Murray JS, et al. Among authors: williams cj. Kidney Int Rep. 2023 Mar 28;8(6):1170-1182. doi: 10.1016/j.ekir.2023.03.003. eCollection 2023 Jun. Kidney Int Rep. 2023. PMID: 37284676 Free PMC article.
INTRODUCTION: People with long-term health conditions often attend clinics for kidney function tests. ...
INTRODUCTION: People with long-term health conditions often attend clinics for kidney function tests. ...
Personalizing neoadjuvant chemotherapy for locally advanced colon cancer: protocols for the international phase III FOxTROT2 and FOxTROT3 randomized controlled trials.
Platt JR, Williams CJM, Craig Z, Cairns DA, Glasbey JC, Morton D, Seligmann J. Platt JR, et al. Among authors: williams cjm. Colorectal Dis. 2023 Mar;25(3):357-366. doi: 10.1111/codi.16487. Epub 2023 Feb 15. Colorectal Dis. 2023. PMID: 36710525 Free article.
DISCUSSION: FOxTROT2 and FOxTROT3 will establish the FOxTROT platform, a key part of our long-term strategy to develop neoadjuvant treatments for CC. FOxTROT2 will investigate NAC in a population under-represented in FOxTROT1 and wider research. FOxTROT3 will assess whethe …
DISCUSSION: FOxTROT2 and FOxTROT3 will establish the FOxTROT platform, a key part of our long-term strategy to develop neoadjuvant tr …
Incorporating neoadjuvant chemotherapy into locally advanced colon cancer treatment pathways: Real-life experience of implementing FOxTROT.
Williams CJ, Fish R, Akerman L, West N, Tolan D, Quyn AJ, Seligmann JF. Williams CJ, et al. Colorectal Dis. 2023 Mar;25(3):352-356. doi: 10.1111/codi.16450. Epub 2023 Feb 6. Colorectal Dis. 2023. PMID: 36511125 Free article. Clinical Trial.
CONCLUSION: Use of NAC for locally advanced colon cancer has been shown to improve surgical outcomes and longer term cancer outcomes. Provision of NAC requires some modifications to current treatment pathways but can be delivered with team working and without the requireme …
CONCLUSION: Use of NAC for locally advanced colon cancer has been shown to improve surgical outcomes and longer term cancer outcomes. …
Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.
Jefferson TB, Wang T, Jefferson WN, Li Y, Hamilton KJ, Wade PA, Williams CJ, Korach KS. Jefferson TB, et al. Among authors: williams cj. Epigenetics. 2023 Dec;18(1):2139986. doi: 10.1080/15592294.2022.2139986. Epub 2022 Nov 3. Epigenetics. 2023. PMID: 36328762 Free PMC article.
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male and female mice. .. …
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and fem …
PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.
Savy V, Stein P, Shi M, Williams CJ. Savy V, et al. Among authors: williams cj. Biol Reprod. 2022 Dec 10;107(6):1439-1451. doi: 10.1093/biolre/ioac180. Biol Reprod. 2022. PMID: 36130203 Free PMC article.
Our results show that global PMCA1 haploinsufficiency impacts growth and support that abnormal Ca2+ signaling after fertilization in vivo has a long-term impact on offspring weight. These findings are relevant for environmental and medical conditions affecting Ca2+ handlin …
Our results show that global PMCA1 haploinsufficiency impacts growth and support that abnormal Ca2+ signaling after fertilization in vivo ha …
Past terrestrial hydroclimate sensitivity controlled by Earth system feedbacks.
Feng R, Bhattacharya T, Otto-Bliesner BL, Brady EC, Haywood AM, Tindall JC, Hunter SJ, Abe-Ouchi A, Chan WL, Kageyama M, Contoux C, Guo C, Li X, Lohmann G, Stepanek C, Tan N, Zhang Q, Zhang Z, Han Z, Williams CJR, Lunt DJ, Dowsett HJ, Chandan D, Peltier WR. Feng R, et al. Among authors: williams cjr. Nat Commun. 2022 Mar 14;13(1):1306. doi: 10.1038/s41467-022-28814-7. Nat Commun. 2022. PMID: 35288559 Free PMC article.
Here, using a compilation of proxy data and multi-model paleoclimate simulations, we show that the mid-Pliocene hydroclimate state is not driven by direct CO(2) radiative forcing but by a loss of northern high-latitude ice sheets and continental greening. These ice sheet and vege …
Here, using a compilation of proxy data and multi-model paleoclimate simulations, we show that the mid-Pliocene hydroclimate state is not dr …
Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder.
Hindi EA, Williams CJ, Zeef LAH, Lopes FM, Newman K, Davey MMM, Hodson NW, Hilton EN, Huang JL, Price KL, Roberts NA, Long DA, Woolf AS, Gardiner NJ. Hindi EA, et al. Among authors: williams cj. Sci Rep. 2021 Jul 30;11(1):15529. doi: 10.1038/s41598-021-94532-7. Sci Rep. 2021. PMID: 34330963 Free PMC article.
Thus, altered extracellular matrix with reduced tissue rigidity may contribute to voiding dysfunction in people with long-term DM. These results serve as an informative stepping stone towards understanding the complex pathobiology of diabetic cystopathy....
Thus, altered extracellular matrix with reduced tissue rigidity may contribute to voiding dysfunction in people with long-term DM. Th …
37 results