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Assessing the therapeutic potential of lab-made hepatocytes.
Rezvani M, Grimm AA, Willenbring H. Rezvani M, et al. Among authors: willenbring h. Hepatology. 2016 Jul;64(1):287-94. doi: 10.1002/hep.28569. Epub 2016 May 26. Hepatology. 2016. PMID: 27014802 Free PMC article. Review.
Ideally, they are also autologous to eliminate the need for immune suppression, which can have severe side effects and may not be sufficient to prevent rejection long term. In the past decade, several methods have been developed to generate hepatocytes from other readily a …
Ideally, they are also autologous to eliminate the need for immune suppression, which can have severe side effects and may not be sufficient …
Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.
Espejel S, Eckardt S, Harbell J, Roll GR, McLaughlin KJ, Willenbring H. Espejel S, et al. Among authors: willenbring h. Stem Cells. 2014 Jul;32(7):1983-8. doi: 10.1002/stem.1726. Stem Cells. 2014. PMID: 24740448 Free PMC article.
In developmental chimeras generated by injecting wild-type PG ESCs into Fah-deficient blastocysts, PG ESCs differentiated into hepatocytes that could repopulate the liver, provide normal liver function, and facilitate long-term survival of adult mice. Moreover, after trans …
In developmental chimeras generated by injecting wild-type PG ESCs into Fah-deficient blastocysts, PG ESCs differentiated into hepatocytes t …
Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice.
Roll GR, Willenbring H. Roll GR, et al. Among authors: willenbring h. Stem Cell Res. 2010 Nov;5(3):267-70. doi: 10.1016/j.scr.2010.07.004. Epub 2010 Aug 5. Stem Cell Res. 2010. PMID: 20829142 Free article.
Human albumin levels peak 24h after injection of hepatocyte debris, and remain detectable at significant levels for at least 8 days. Our finding suggests that long-term, or in situ, analyses are needed to prove functional engraftment of human primary or stem cell-derived h …
Human albumin levels peak 24h after injection of hepatocyte debris, and remain detectable at significant levels for at least 8 days. Our fin …
On the origin of the term "stem cell".
Ramalho-Santos M, Willenbring H. Ramalho-Santos M, et al. Among authors: willenbring h. Cell Stem Cell. 2007 Jun 7;1(1):35-38. doi: 10.1016/j.stem.2007.05.013. Cell Stem Cell. 2007. PMID: 18371332 Free article.
Stem cells have fascinated both biologists and clinicians for over a century. Here, we discuss the origin of the term "stem cell," which can be traced back to the late 19th century. ...Theodor Boveri and Valentin Hacker used the term stem cell to describe cells comm …
Stem cells have fascinated both biologists and clinicians for over a century. Here, we discuss the origin of the term "stem cell," wh …
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, Grompe M, Fleming WH, Wong MH. Rizvi AZ, et al. Among authors: willenbring h. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6321-5. doi: 10.1073/pnas.0508593103. Epub 2006 Apr 10. Proc Natl Acad Sci U S A. 2006. PMID: 16606845 Free PMC article.
Here, we show that transplanted BMDCs fuse with both normal and neoplastic intestinal epithelium. Long-term repopulation by donor-derived cells was detected in all principal intestinal epithelial lineages including enterocytes, goblet cells, Paneth cells, and enteroendocri …
Here, we show that transplanted BMDCs fuse with both normal and neoplastic intestinal epithelium. Long-term repopulation by donor-der …
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M. Vogel A, et al. Among authors: willenbring h. Gastroenterology. 2006 Jan;130(1):104-19. doi: 10.1053/j.gastro.2005.10.012. Gastroenterology. 2006. PMID: 16401474 Free PMC article.
Furthermore, resistance to apoptosis in chronic cholestasis may contribute to the long-term risk of cancer in this setting....
Furthermore, resistance to apoptosis in chronic cholestasis may contribute to the long-term risk of cancer in this setting....