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Page 1
Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning.
Tanaka M, Yamaguchi K, Tatsukawa T, Nishioka C, Nishiyama H, Theis M, Willecke K, Itohara S. Tanaka M, et al. Among authors: willecke k. Front Behav Neurosci. 2008 Apr 23;2:1. doi: 10.3389/neuro.08.001.2008. eCollection 2008. Front Behav Neurosci. 2008. PMID: 18958191 Free PMC article.
Although gap junctional coupling between the Bergmann glial cells measured by spreading of microinjected Lucifer yellow was virtually abolished in Cx43(fl/fl):S100b-Cre mice, electrophysiologic analysis revealed that cerebellar long-term depression could be induced and mai …
Although gap junctional coupling between the Bergmann glial cells measured by spreading of microinjected Lucifer yellow was virtually abolis …
Connexin-caused genetic diseases and corresponding mouse models.
Dobrowolski R, Willecke K. Dobrowolski R, et al. Among authors: willecke k. Antioxid Redox Signal. 2009 Feb;11(2):283-95. doi: 10.1089/ars.2008.2128. Antioxid Redox Signal. 2009. PMID: 18831677 Review.
In this review, we discuss advantages and problems of such an approach and possible implications regarding the mechanism of the disease. The long-term goal is to understand the biologic function of each connexin isoform and the contribution of these proteins to the physiol …
In this review, we discuss advantages and problems of such an approach and possible implications regarding the mechanism of the disease. The …
Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition.
Döring B, Shynlova O, Tsui P, Eckardt D, Janssen-Bienhold U, Hofmann F, Feil S, Feil R, Lye SJ, Willecke K. Döring B, et al. Among authors: willecke k. J Cell Sci. 2006 May 1;119(Pt 9):1715-22. doi: 10.1242/jcs.02892. Epub 2006 Apr 4. J Cell Sci. 2006. PMID: 16595547
Gap junctions are characteristically increased in the myometrium during term and preterm delivery and are thought to be essential for the development of uterine contractions during labour. ...We have generated a mouse mutant (Cx43fl/fl:SM-CreERT2), in which the coding regi …
Gap junctions are characteristically increased in the myometrium during term and preterm delivery and are thought to be essential for …
Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.
Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. Lin JH, et al. Among authors: willecke k. J Neurosci. 2002 Jun 1;22(11):4302-11. doi: 10.1523/JNEUROSCI.22-11-04302.2002. J Neurosci. 2002. PMID: 12040035 Free PMC article.
Astrocytic tumors express the gap junction protein connexin 43 (Cx43), and we show here that Cx43 expression induced the morphological transformation of glioma cells into an epithelial phenotype. In a short-term aggregation assay, Cx43 expression was associated with a seve …
Astrocytic tumors express the gap junction protein connexin 43 (Cx43), and we show here that Cx43 expression induced the morphological trans …
Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells.
Houghton FD, Thönnissen E, Kidder GM, Naus CC, Willecke K, Winterhager E. Houghton FD, et al. Among authors: willecke k. Dev Genet. 1999;24(1-2):5-12. doi: 10.1002/(SICI)1520-6408(1999)24:1/2<5::AID-DVG2>3.0.CO;2-F. Dev Genet. 1999. PMID: 10079506
In the present study, we have tested this hypothesis by interbreeding mice carrying null mutations in the genes (Gjb1 and Gja1) encoding connexin32 (beta 1 connexin) and connexin43 (alpha 1 connexin), respectively. We found that fetuses lacking both connexins survive to term …
In the present study, we have tested this hypothesis by interbreeding mice carrying null mutations in the genes (Gjb1 and Gja1) encoding con …
Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and long-term cultured astrocytes.
Kunzelmann P, Schröder W, Traub O, Steinhäuser C, Dermietzel R, Willecke K. Kunzelmann P, et al. Among authors: willecke k. Glia. 1999 Jan 15;25(2):111-9. doi: 10.1002/(sici)1098-1136(19990115)25:2<111::aid-glia2>3.0.co;2-i. Glia. 1999. PMID: 9890626
In rat brain, expression of the gap junction protein connexin30 increased during the first 3 weeks after birth and reached its maximum after 4 weeks, as shown by analysis with specific connexin30 antibodies. ...This late onset of connexin30 expression in astrocytes was als …
In rat brain, expression of the gap junction protein connexin30 increased during the first 3 weeks after birth and reached its maximu …
Expression of different connexin genes in rat uterus during decidualization and at term.
Winterhager E, Stutenkemper R, Traub O, Beyer E, Willecke K. Winterhager E, et al. Among authors: willecke k. Eur J Cell Biol. 1991 Jun;55(1):133-42. Eur J Cell Biol. 1991. PMID: 1655436
The expression of different connexin genes (cx26, cx32, cx37, cx43) that code for the protein subunits of gap junctions, was investigated in various uterine tissues during the estrous cycle of nonpregnant rats, in pregnant rats at decidualization and at term. Connexin gene …
The expression of different connexin genes (cx26, cx32, cx37, cx43) that code for the protein subunits of gap junctions, was investigated in …