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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Alexander SPH, et al. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748. Br J Pharmacol. 2019. PMID: 31710717 Free PMC article. Review.
Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.
Coopman K, Huang Y, Johnston N, Bradley SJ, Wilkinson GF, Willars GB. Coopman K, et al. Among authors: willars gb. J Pharmacol Exp Ther. 2010 Sep 1;334(3):795-808. doi: 10.1124/jpet.110.166009. Epub 2010 May 27. J Pharmacol Exp Ther. 2010. PMID: 20507928 Free PMC article.
Full assessment of the properties of compound 2 was potentially hampered by damaging effects that were particularly manifest in either longer term assays with intact cells or in acute assays with membranes....
Full assessment of the properties of compound 2 was potentially hampered by damaging effects that were particularly manifest in either longe …
Full and partial agonists of muscarinic M3 receptors reveal single and oscillatory Ca2+ responses by beta 2-adrenoceptors.
Kurian N, Hall CJ, Wilkinson GF, Sullivan M, Tobin AB, Willars GB. Kurian N, et al. Among authors: willars gb. J Pharmacol Exp Ther. 2009 Aug;330(2):502-12. doi: 10.1124/jpet.109.153619. Epub 2009 May 6. J Pharmacol Exp Ther. 2009. PMID: 19420300 Free PMC article.
Although these receptor subtypes are often coexpressed and mediate contrasting acute physiological effects, altered oscillatory Ca(2+) signaling suggests that cross-talk could influence longer term events through, for example, regulating gene transcription....
Although these receptor subtypes are often coexpressed and mediate contrasting acute physiological effects, altered oscillatory Ca(2+) signa …
Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition.
Willars GB, Calcutt NA, Compton AM, Tomlinson DR, Keen P. Willars GB, et al. J Neurol Sci. 1989 Jun;91(1-2):153-64. doi: 10.1016/0022-510x(89)90084-1. J Neurol Sci. 1989. PMID: 2473171
This study measured the content of substance P-like immunoreactivity (SPLI) in peripheral nervous tissue (lumbar dorsal root ganglia, sciatic nerve), skin (snout, foot), gastrointestinal tract (stomach, terminal ileum) and in the atria of the heart. Animals studied were long-t …
This study measured the content of substance P-like immunoreactivity (SPLI) in peripheral nervous tissue (lumbar dorsal root ganglia, sciati …
Ganglioside treatment of streptozotocin-diabetic rats prevents defective axonal transport of 6-phosphofructokinase activity.
Calcutt NA, Tomlinson DR, Willars GB. Calcutt NA, et al. Among authors: willars gb. J Neurochem. 1988 May;50(5):1478-83. doi: 10.1111/j.1471-4159.1988.tb03033.x. J Neurochem. 1988. PMID: 2452237
This study measured axonal transport of 6-phosphofructokinase (PFK) and aldolase activities in the sciatic nerves of rats with short-term streptozotocin-induced diabetes. The diabetic rats showed deficits in anterograde (69% of controls; p less than 0.001) and retrograde ( …
This study measured axonal transport of 6-phosphofructokinase (PFK) and aldolase activities in the sciatic nerves of rats with short-term …
Reduced anterograde and retrograde accumulation of axonally transported phosphofructokinase in streptozotocin-diabetic rats: effects of insulin and the aldose reductase inhibitor 'Statil'.
Willars GB, Calcutt NA, Tomlinson DR. Willars GB, et al. Diabetologia. 1987 Apr;30(4):239-43. doi: 10.1007/BF00270422. Diabetologia. 1987. PMID: 2439402
In spite of these indications of effective aldose reductase inhibition, the drug was without effect on the deficits in accumulation of activity at ligatures or unconstricted nerve levels of phosphofructokinase activity. We conclude that short-term experimental diabetes in …
In spite of these indications of effective aldose reductase inhibition, the drug was without effect on the deficits in accumulation of activ …
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway.
Tomlinson DR, Willars GB, Calthrop-Owen EF. Tomlinson DR, et al. Among authors: willars gb. Exp Neurol. 1987 Apr;96(1):194-202. doi: 10.1016/0014-4886(87)90180-4. Exp Neurol. 1987. PMID: 2435570
This effective inhibition of aldose reductase did not alter the accumulation deficits of phosphofructokinase activity on either side of sciatic nerve constrictions. We conclude that short-term experimental diabetes causes impaired axonal transport of phosphofructokinase ac …
This effective inhibition of aldose reductase did not alter the accumulation deficits of phosphofructokinase activity on either side of scia …
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Willars GB, Tomlinson DR, Robinson JP. Willars GB, et al. Metabolism. 1986 Apr;35(4 Suppl 1):66-70. doi: 10.1016/0026-0495(86)90190-3. Metabolism. 1986. PMID: 2421136
Deficits of axonal transport in short-term experimental diabetes may be a consequence of increased sorbitol pathway flux and may contribute to the development of degenerative neuropathies. Therefore, we studied the effect of the aldose reductase inhibitor sorbinil on the a …
Deficits of axonal transport in short-term experimental diabetes may be a consequence of increased sorbitol pathway flux and may cont …