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Concurrent RB1 loss and BRCA-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.
Saner FAM, Takahashi K, Budden T, Pandey A, Ariyaratne D, Zwimpfer TA, Meagher NS, Fereday S, Twomey L, Pishas KI, Hoang T, Bolithon A, Traficante N, Alsop K, Christie EL, Kang EY, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Alsop J, Beckmann MW, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, El-Bahrawy MA, Elishaev E, Erber R, Gayther SA, Gentry-Maharaj A, Blake Gilks C, Harnett PR, Harris HR, Hartmann A, Hein A, Hendley J; AOCS Group; Hernandez BY, Jakubowska A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Kluz T, Koziak JM, Kristjansdottir B, Le ND, Lener M, Lester J, Lubiński J, Mateoiu C, Orsulic S, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Rinda Soong T, Steed H, Sukumvanich P, Talhouk A, Taylor SE, Vierkant RA, Wang C, Widschwendter M, Wilkens LR, Winham SJ, Anglesio MS, Berchuck A, Brenton JD, Campbell I, Cook LS, Doherty JA, Fasching PA, Fortner RT, Goodman MT, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Menon U, Modugno F, Pharoah PDP, Schildkraut JM, Sundfeldt K, Swerdlow AJ, Goode EL, DeFazio A, Köbel M, Ramus SJ, Bowtell DDL, Garsed DW. Saner FAM, et al. Among authors: wilkens lr. medRxiv [Preprint]. 2023 Nov 10:2023.11.09.23298321. doi: 10.1101/2023.11.09.23298321. medRxiv. 2023. PMID: 37986741 Free PMC article. Preprint.
We examined whether tumour expression of RB1 was associated with survival across ovarian cancer histotypes (HGSC, endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous carcinoma (LGSC)), and how co-occurrence of germline BRCA pathogenic variants and RB1 loss in …
We examined whether tumour expression of RB1 was associated with survival across ovarian cancer histotypes (HGSC, endometrioid (ENOC), clear …
Maintenance Outcomes of the Children's Healthy Living Program on Overweight, Obesity, and Acanthosis Nigricans Among Young Children in the US-Affiliated Pacific Region: A Randomized Clinical Trial.
Novotny R, Yamanaka AB, Butel J, Boushey CJ, Dela Cruz R, Aflague T, Coleman P, Shallcross L, Fleming T, Wilkens LR. Novotny R, et al. Among authors: wilkens lr. JAMA Netw Open. 2022 Jun 1;5(6):e2214802. doi: 10.1001/jamanetworkopen.2022.14802. JAMA Netw Open. 2022. PMID: 35666503 Free PMC article. Clinical Trial.
IMPORTANCE: Few obesity prevention trials among children have demonstrated sustainable outcomes in the long term. OBJECTIVES: To sustain a community-wide decrease in the prevalence of overweight and obesity among young children in the US-affiliated Pacific region. ...
IMPORTANCE: Few obesity prevention trials among children have demonstrated sustainable outcomes in the long term. OBJECTIVES: To sust …
Long-term association between diet quality and characteristics of the gut microbiome in the multiethnic cohort study.
Ma E, Maskarinec G, Lim U, Boushey CJ, Wilkens LR, Setiawan VW, Le Marchand L, Randolph TW, Jenkins IC, Curtis KR, Lampe JW, Hullar MAJ. Ma E, et al. Among authors: wilkens lr. Br J Nutr. 2021 Aug 9:1-10. doi: 10.1017/S0007114521002968. Online ahead of print. Br J Nutr. 2021. PMID: 34369335 Free PMC article.
The quality of past diet, assessed as far as 20 years before stool collection, is equally predictive of GM composition as concurrently assessed diet, indicative of the long-term consistency of this relation....
The quality of past diet, assessed as far as 20 years before stool collection, is equally predictive of GM composition as concurrently asses …
Changes in diet quality and body weight over 10 years: the Multiethnic Cohort Study.
Kang M, Boushey CJ, Shvetsov YB, Setiawan VW, Paik HY, Wilkens LR, Le Marchand L, Park SY. Kang M, et al. Among authors: wilkens lr. Br J Nutr. 2021 Nov 14;126(9):1389-1397. doi: 10.1017/S000711452100012X. Epub 2021 Jan 14. Br J Nutr. 2021. PMID: 33441193 Free PMC article.
High-quality diets have been found to be beneficial in preventing long-term weight gain. However, concurrent changes in diet quality and body weight over time have rarely been reported. ...
High-quality diets have been found to be beneficial in preventing long-term weight gain. However, concurrent changes in diet quality …
Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium.
Jordan SJ, Na R, Weiderpass E, Adami HO, Anderson KE, van den Brandt PA, Brinton LA, Chen C, Cook LS, Doherty JA, Du M, Friedenreich CM, Gierach GL, Goodman MT, Krogh V, Levi F, Lu L, Miller AB, McCann SE, Moysich KB, Negri E, Olson SH, Petruzella S, Palmer JR, Parazzini F, Pike MC, Prizment AE, Rebbeck TR, Reynolds P, Ricceri F, Risch HA, Rohan TE, Sacerdote C, Schouten LJ, Serraino D, Setiawan VW, Shu XO, Sponholtz TR, Spurdle AB, Stolzenberg-Solomon RZ, Trabert B, Wentzensen N, Wilkens LR, Wise LA, Yu H, La Vecchia C, De Vivo I, Xu W, Zeleniuch-Jacquotte A, Webb PM. Jordan SJ, et al. Among authors: wilkens lr. Int J Cancer. 2021 May 1;148(9):2068-2078. doi: 10.1002/ijc.33360. Epub 2020 Nov 17. Int J Cancer. 2021. PMID: 33105052 Free PMC article.
The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further ~15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. ...Ou …
The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further ~15% reducti …
Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium.
Butt J, Blot WJ, Visvanathan K, Le Marchand L, Wilkens LR, Chen Y, Sesso HD, Teras L, Ryser MD, Hyslop T, Wassertheil-Smoller S, Tinker LF, Potter JD, Song M, Berndt SI, Waterboer T, Pawlita M, Epplein M. Butt J, et al. Among authors: wilkens lr. Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2729-2734. doi: 10.1158/1055-9965.EPI-20-0780. Epub 2020 Sep 24. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32972968 Free PMC article.
IMPACT: Our finding suggests that p53 seropositivity may not be a useful predictor of long-term colorectal cancer risk; however, it might be considered as a marker to aid in the early diagnosis of colorectal cancer....
IMPACT: Our finding suggests that p53 seropositivity may not be a useful predictor of long-term colorectal cancer risk; however, it m …
The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.
Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV Jr, Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T; COPE Consortium. Chan AT, et al. Among authors: wilkens lr. Cancer Epidemiol Biomarkers Prev. 2020 Jul;29(7):1283-1289. doi: 10.1158/1055-9965.EPI-20-0606. Epub 2020 May 5. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32371551 Free PMC article. Review.
The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COron …
The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time c …
Mediators of a 12-month change in physical activity in ethnically diverse sample of postpartum women.
Albright CL, Wilkens LR, Saiki K, White KK, Steffen AD. Albright CL, et al. Among authors: wilkens lr. Transl J Am Coll Sports Med. 2019 Oct;4(19):215-224. doi: 10.1249/TJX.0000000000000106. Transl J Am Coll Sports Med. 2019. PMID: 31984225 Free PMC article.
PURPOSE: Understanding theoretically derived social and behavioral mediators of long-term increases in physical activity (PA) in a vulnerable population at risk for being underactive is needed to inform future research, clinical applications, and public health efforts. Thi …
PURPOSE: Understanding theoretically derived social and behavioral mediators of long-term increases in physical activity (PA) in a vu …
Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC).
Aumueller N, Boushey CJ, Franke AA, Cooney RV, Monroe KR, Haiman CA, Wilkens LR, Kolonel LN, Le Marchand L, Maskarinec G. Aumueller N, et al. Among authors: wilkens lr. Eur J Clin Nutr. 2019 May;73(5):703-713. doi: 10.1038/s41430-018-0272-1. Epub 2018 Aug 2. Eur J Clin Nutr. 2019. PMID: 30072814 Free PMC article.
BACKGROUND/OBJECTIVES: This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. ...
BACKGROUND/OBJECTIVES: This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by fo …
Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort.
Setiawan VW, Stram DO, Porcel J, Chari ST, Maskarinec G, Le Marchand L, Wilkens LR, Haiman CA, Pandol SJ, Monroe KR. Setiawan VW, et al. Among authors: wilkens lr. J Natl Cancer Inst. 2019 Jan 1;111(1):27-33. doi: 10.1093/jnci/djy090. J Natl Cancer Inst. 2019. PMID: 29917105 Free PMC article.
Individuals with recent-onset diabetes (within three or fewer years of PC diagnosis) had a greater risk compared with those with long-term diabetes across all ages. The HRage75 for recent-onset diabetes was 4.08 (95% CI = 2.76 to 6.03) in Latinos and 3.38 (95% CI = 2.30 to …
Individuals with recent-onset diabetes (within three or fewer years of PC diagnosis) had a greater risk compared with those with long-ter …
28 results