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Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.
Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.
Sci Transl Med. 2013.
PMID: 24259050
Free PMC article.
We recently demonstrated effective inhibition of entire miRNA families using seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiRs in short-term experiments in mammalian cells and in mice. However, the long-term efficacy and safety of this approach in hig …
We recently demonstrated effective inhibition of entire miRNA families using seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiR …
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