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Biologic Therapy in Rare Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities.
Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD; International Eosinophil Society Clinical Research Interest Group. Khoury P, et al. J Leukoc Biol. 2024 Mar 8:qiae051. doi: 10.1093/jleuko/qiae051. Online ahead of print. J Leukoc Biol. 2024. PMID: 38457125
Key topics of interest included: 1) clinical outcome measures, 2) minimally invasive biomarkers of disease activity, 3) predictors of response to biologic agents, and 4) long-term safety of eosinophil depletion. Herein, we report a summary of these discussions, presenting …
Key topics of interest included: 1) clinical outcome measures, 2) minimally invasive biomarkers of disease activity, 3) predictors of respon …
The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources.
DiStefano MT, Goehringer S, Babb L, Alkuraya FS, Amberger J, Amin M, Austin-Tse C, Balzotti M, Berg JS, Birney E, Bocchini C, Bruford EA, Coffey AJ, Collins H, Cunningham F, Daugherty LC, Einhorn Y, Firth HV, Fitzpatrick DR, Foulger RE, Goldstein J, Hamosh A, Hurles MR, Leigh SE, Leong IUS, Maddirevula S, Martin CL, McDonagh EM, Olry A, Puzriakova A, Radtke K, Ramos EM, Rath A, Riggs ER, Roberts AM, Rodwell C, Snow C, Stark Z, Tahiliani J, Tweedie S, Ware JS, Weller P, Williams E, Wright CF, Yates TM, Rehm HL. DiStefano MT, et al. Among authors: weller p. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4. Genet Med. 2022. PMID: 35507016 Free PMC article.
RESULTS: On the basis of 241 survey responses from the genetics community, a consensus term set was chosen for grading gene-disease validity and database submissions. ...
RESULTS: On the basis of 241 survey responses from the genetics community, a consensus term set was chosen for grading gene-disease v …
Semantic Knowledge Enhances Conscious Awareness of Visual Objects.
Weller PD, Rabovsky M, Abdel Rahman R. Weller PD, et al. J Cogn Neurosci. 2019 Aug;31(8):1216-1226. doi: 10.1162/jocn_a_01404. Epub 2019 Apr 2. J Cogn Neurosci. 2019. PMID: 30938592
It is becoming increasingly established that information from long-term memory can influence early perceptual processing, a finding that is in line with recent theoretical approaches to cognition such as the predictive coding framework. ...
It is becoming increasingly established that information from long-term memory can influence early perceptual processing, a finding t …
Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b.
Enga RM, Rice AC, Weller P, Subler MA, Lee D, Hall CP, Windle JJ, Beardsley PM, van den Oord EJ, McClay JL. Enga RM, et al. Among authors: weller p. Neurosci Lett. 2017 Feb 22;641:26-32. doi: 10.1016/j.neulet.2017.01.044. Epub 2017 Jan 20. Neurosci Lett. 2017. PMID: 28115237 Free PMC article.
As an intermediary between post-synaptic receptor stimulation and long-term changes to neuronal protein expression, further investigation of Anks1b is warranted....
As an intermediary between post-synaptic receptor stimulation and long-term changes to neuronal protein expression, further investiga …
Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
Dertinger SD, Phonethepswath S, Avlasevich SL, Torous DK, Mereness J, Bryce SM, Bemis JC, Bell S, Weller P, Macgregor JT. Dertinger SD, et al. Among authors: weller p. Toxicol Sci. 2012 Dec;130(2):328-48. doi: 10.1093/toxsci/kfs258. Epub 2012 Aug 24. Toxicol Sci. 2012. PMID: 22923490 Free PMC article.
The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET) frequency in short-term and repeated dosing schedules was investigated using the recently developed flow cytometric Pig-a mutation assay and flow cytometric micronucleus analysis. ...
The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET) frequency in short-term and repeated dosing …
In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.
Torous DK, Phonethepswath S, Avlasevich SL, Mereness J, Bryce SM, Bemis JC, Weller P, Bell S, Gleason C, Custer LL, MacGregor JT, Dertinger SD. Torous DK, et al. Among authors: weller p. Environ Mol Mutagen. 2012 Jul;53(6):420-8. doi: 10.1002/em.21709. Epub 2012 Jun 22. Environ Mol Mutagen. 2012. PMID: 22730284
This laboratory has developed flow cytometric scoring techniques for monitoring two blood-based genotoxicity endpoints-micronucleated reticulocyte frequency and gene mutation at the Pig-a locus-thereby making combination and integration studies practical. The ability to effective …
This laboratory has developed flow cytometric scoring techniques for monitoring two blood-based genotoxicity endpoints-micronucleated reticu …
The standardized and mini versions of the PAQLQ are valid, reliable, and responsive measurement tools.
Wing A, Upton J, Svensson K, Weller P, Fletcher M, Walker S. Wing A, et al. Among authors: weller p. J Clin Epidemiol. 2012 Jun;65(6):643-50. doi: 10.1016/j.jclinepi.2011.12.009. J Clin Epidemiol. 2012. PMID: 22537468
CONCLUSION: The PAQLQ(S) and the MiniPAQLQ are valid, reliable and responsive to change. They can be used with confidence for long-term monitoring in clinical trials....
CONCLUSION: The PAQLQ(S) and the MiniPAQLQ are valid, reliable and responsive to change. They can be used with confidence for long-term …
Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes.
Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Haferlach T, Simon HU, Reiter A, Gleich GJ. Valent P, et al. Among authors: weller pf. J Allergy Clin Immunol. 2012 Sep;130(3):607-612.e9. doi: 10.1016/j.jaci.2012.02.019. Epub 2012 Mar 28. J Allergy Clin Immunol. 2012. PMID: 22460074 Free PMC article.
For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. ...
For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined signifi …
Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments.
Melo RC, Spencer LA, Perez SA, Ghiran I, Dvorak AM, Weller PF. Melo RC, et al. Among authors: weller pf. Traffic. 2005 Nov;6(11):1047-57. doi: 10.1111/j.1600-0854.2005.00344.x. Traffic. 2005. PMID: 16190985 Free PMC article.
Interleukin-4 traffics from granules via two vesicular compartments, large vesiculotubular carriers, which we term eosinophil sombrero vesicles (EoSV), and small classical spherical vesicles. ...
Interleukin-4 traffics from granules via two vesicular compartments, large vesiculotubular carriers, which we term eosinophil sombrer …
Recommendations for the use of palivizumab as prophylaxis against respiratory syncytial virus in infants with congenital cardiac disease.
Tulloh R, Marsh M, Blackburn M, Casey F, Lenney W, Weller P, Keeton BR; Working Group of the British Paediatric Cardiac Association. Tulloh R, et al. Among authors: weller p. Cardiol Young. 2003 Oct;13(5):420-3. Cardiol Young. 2003. PMID: 14694935
Infants, namely those under 1 year old, with congenital cardiac disease likely to benefit from prophylaxis include those with haemodynamically significant lesions, particularly increased pulmonary blood flow with or without cyanosis; pulmonary venous congestion, pulmonary hyperte …
Infants, namely those under 1 year old, with congenital cardiac disease likely to benefit from prophylaxis include those with haemodynamical …
19 results