Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

40 results

Filters applied: . Clear all
Page 1
Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy to treat murine liver diseases.
Smith AR, Rizvi F, Everton E, Adeagbo A, Wu S, Tam Y, Muramatsu H, Pardi N, Weissman D, Gouon-Evans V. Smith AR, et al. Among authors: weissman d. bioRxiv [Preprint]. 2024 Jan 11:2024.01.11.575286. doi: 10.1101/2024.01.11.575286. bioRxiv. 2024. PMID: 38260488 Free PMC article. Preprint.
However, currently PHH engraftment efficiency is low and benefits are not maintained long-term. Here we refine two mouse models of human chronic and acute liver diseases to recapitulate compromised hepatocyte proliferation observed in nearly all human liver diseases by ove …
However, currently PHH engraftment efficiency is low and benefits are not maintained long-term. Here we refine two mouse models of hu …
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.
Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. Billingsley MM, et al. Among authors: weissman d. Small. 2024 Mar;20(11):e2304378. doi: 10.1002/smll.202304378. Epub 2023 Dec 10. Small. 2024. PMID: 38072809
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high production costs and long-term side effects. Thus, this work aims to develop an in vivo CAR T cell engineering platform to streamline produc …
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high product …
Fifty shades of greenbeard: robust evolution of altruism based on similarity of complex phenotypes.
Båvik LM, Mehta RS, Weissman DB. Båvik LM, et al. Among authors: weissman db. Proc Biol Sci. 2023 Jun 14;290(2000):20222579. doi: 10.1098/rspb.2022.2579. Epub 2023 Jun 14. Proc Biol Sci. 2023. PMID: 37312545
Altruism is therefore robust to invasion by cheaters in the long term in this model. Furthermore, the shape of the phenotype distribution in high phenotypic dimension allows altruists to better resist the invasion by cheaters, and as a result the amount of donation increas …
Altruism is therefore robust to invasion by cheaters in the long term in this model. Furthermore, the shape of the phenotype distribu …
Malignant Mesothelioma Mortality in Women - United States, 1999-2020.
Mazurek JM, Blackley DJ, Weissman DN. Mazurek JM, et al. Among authors: weissman dn. MMWR Morb Mortal Wkly Rep. 2022 May 13;71(19):645-649. doi: 10.15585/mmwr.mm7119a1. MMWR Morb Mortal Wkly Rep. 2022. PMID: 35552365 Free PMC article.
Occupational asbestos exposure is most often reported in men working in industries such as construction and manufacturing; however, women are also at risk for exposure to asbestos fibers, and limited data exist on longer-term trends in mesothelioma deaths among women. To c …
Occupational asbestos exposure is most often reported in men working in industries such as construction and manufacturing; however, women ar …
Long-term impact of a 4-day feed restriction at the protozoea stage on metabolic gene expressions of whiteleg shrimp (Litopenaeus vannamei).
Lage LPA, Weissman D, Serusier M, Putrino SM, Baron F, Guyonvarch A, Tournat M, Nunes AJP, Panserat S. Lage LPA, et al. Among authors: weissman d. PeerJ. 2020 Mar 20;8:e8715. doi: 10.7717/peerj.8715. eCollection 2020. PeerJ. 2020. PMID: 32219024 Free PMC article.
We analyzed long-term programming of shrimp by studying metabolism at the molecular level, through RT-qPCR of key biomarkers (involved in intermediary metabolism and digestion). ...This suggests a possible long-term modification of the metabolism that is linked to t …
We analyzed long-term programming of shrimp by studying metabolism at the molecular level, through RT-qPCR of key biomarkers (involve …
Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice.
Willis E, Pardi N, Parkhouse K, Mui BL, Tam YK, Weissman D, Hensley SE. Willis E, et al. Among authors: weissman d. Sci Transl Med. 2020 Jan 8;12(525):eaav5701. doi: 10.1126/scitranslmed.aav5701. Sci Transl Med. 2020. PMID: 31915303 Free PMC article.
Maternal antibodies provide short-term protection to infants against many infections. However, they can inhibit de novo antibody responses in infants elicited by infections or vaccination, leading to increased long-term susceptibility to infectious diseases. ...
Maternal antibodies provide short-term protection to infants against many infections. However, they can inhibit de novo antibody resp …
Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis.
Nee JW, Johnston JM, Shea EP, Walls CE, Tripp K, Shiff S, Fox SM, Bochenek W, Weissman D, Currie MG, Lembo AJ. Nee JW, et al. Among authors: weissman d. Expert Rev Gastroenterol Hepatol. 2019 Apr;13(4):397-406. doi: 10.1080/17474124.2019.1575203. Epub 2019 Feb 18. Expert Rev Gastroenterol Hepatol. 2019. PMID: 30791771
METHODS: In six randomized controlled trials (RCTs), patients received linaclotide (72 g, 145 g, 290 g) or placebo daily for 12-26 weeks; in two long-term safety (LTS) studies, patients received open-label linaclotide for 78 additional weeks. ...
METHODS: In six randomized controlled trials (RCTs), patients received linaclotide (72 g, 145 g, 290 g) or placebo daily for 12-26 weeks; in …
Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?
Li ZT, Zarnitsyna VI, Lowen AC, Weissman D, Koelle K, Kohlmeier JE, Antia R. Li ZT, et al. Among authors: weissman d. J Virol. 2019 Mar 5;93(6):e01534-18. doi: 10.1128/JVI.01534-18. Print 2019 Mar 15. J Virol. 2019. PMID: 30626684 Free PMC article.
Finally, we identify key parameters whose measurement will allow for more accurate quantification of the long-term effectiveness and impact of universal T cell-inducing influenza vaccines.IMPORTANCE Universal influenza vaccines against the conserved epitopes of influenza A …
Finally, we identify key parameters whose measurement will allow for more accurate quantification of the long-term effectiveness and …
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.
Pardi N, Parkhouse K, Kirkpatrick E, McMahon M, Zost SJ, Mui BL, Tam YK, Karikó K, Barbosa CJ, Madden TD, Hope MJ, Krammer F, Hensley SE, Weissman D. Pardi N, et al. Among authors: weissman d. Nat Commun. 2018 Aug 22;9(1):3361. doi: 10.1038/s41467-018-05482-0. Nat Commun. 2018. PMID: 30135514 Free PMC article.
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgentl …
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, …
40 results