In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.
Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ.
Billingsley MM, et al. Among authors: weissman d.
Small. 2024 Mar;20(11):e2304378. doi: 10.1002/smll.202304378. Epub 2023 Dec 10.
Small. 2024.
PMID: 38072809
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high production costs and long-term side effects. Thus, this work aims to develop an in vivo CAR T cell engineering platform to streamline produc …
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high product …