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Development of the PSU Child Pump.
Scheib C, Newswanger R, Cysyk J, Bohnenberger K, Lukic B, Xu L, Yeager E, Bletcher K, Leibich P, Jackson Q, Flory H, Tillinger M, Weiss W, Rosenberg G, Jhun CS. Scheib C, et al. Among authors: weiss w. ASAIO J. 2024 Mar 28. doi: 10.1097/MAT.0000000000002202. Online ahead of print. ASAIO J. 2024. PMID: 38537074
The Pennsylvania State University (PSU) Child Pump, a centrifugal continuous-flow ventricular assist device (cf-VAD), is being developed as a suitable long-term implantable device for pediatric heart failure patients between 10 and 35 kg, body surface area (BSA) of 0.5-1.2 …
The Pennsylvania State University (PSU) Child Pump, a centrifugal continuous-flow ventricular assist device (cf-VAD), is being developed as …
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies.
Becklin KL, Draper GM, Madden RA, Kluesner MG, Koga T, Huang M, Weiss WA, Spector LG, Largaespada DA, Moriarity BS, Webber BR. Becklin KL, et al. Among authors: weiss wa. CRISPR J. 2022 Aug;5(4):517-535. doi: 10.1089/crispr.2022.0032. CRISPR J. 2022. PMID: 35972367 Free PMC article. Review.
Here, we review the status of human iPSC modeling of solid tumors in the context of genetic engineering, including how base and prime editing can be incorporated into "bottom-up" cancer modeling, a term we coined for iPSC-based cancer models using genetic engineering to in …
Here, we review the status of human iPSC modeling of solid tumors in the context of genetic engineering, including how base and prime editin …
Computational Modeling of the Penn State Fontan Circulation Assist Device.
Good BC, Ponnaluri SV, Weiss WJ, Manning KB. Good BC, et al. Among authors: weiss wj. ASAIO J. 2022 Dec 1;68(12):1513-1522. doi: 10.1097/MAT.0000000000001708. Epub 2022 Apr 12. ASAIO J. 2022. PMID: 35421006
To address the increasing number of failing Fontan patients, Penn State University and the Penn State Hershey Medical Center are developing a centrifugal blood pump for long-term mechanical support. Computational fluid dynamics (CFD) modeling of the Penn State Fontan Circu …
To address the increasing number of failing Fontan patients, Penn State University and the Penn State Hershey Medical Center are developing …
Cutting Through the "Gray Area": An Analysis of the IBC Regulatory Oversight of Applications of CRISPR Technology in Clinical Research.
Weiss WF. Weiss WF. Ther Innov Regul Sci. 2021 Sep;55(5):979-983. doi: 10.1007/s43441-021-00294-9. Epub 2021 May 18. Ther Innov Regul Sci. 2021. PMID: 34003474
While the breadth of applications for CRISPR encompasses nearly the entire field of medical science, its utilization to produce next-generation CAR T cells stands to benefit most substantially in the short-term. These novel therapeutics are now beginning to enter the clini …
While the breadth of applications for CRISPR encompasses nearly the entire field of medical science, its utilization to produce next-generat …
Miniaturized Fontan Circulation Assist Device: Chronic In Vivo Evaluation.
Cysyk JP, Lukic B, Joseph Brian C, Newswanger R, Jhun CS, Izer J, Flory H, Reibson J, Doxtater B, Weiss W, Rosenberg G. Cysyk JP, et al. Among authors: weiss w. ASAIO J. 2021 Nov 1;67(11):1240-1249. doi: 10.1097/MAT.0000000000001439. ASAIO J. 2021. PMID: 33883510
We have miniaturized and optimized our implantable rotary blood pump developed to provide long-term mechanical right heart support for patients who have failing Fontan circulation. ...
We have miniaturized and optimized our implantable rotary blood pump developed to provide long-term mechanical right heart support fo …
Effects of metabolizable protein concentration, amino acid profile, and fiber source on the messenger RNA expression of skeletal muscle in peripartum dairy cows.
Tebbe AW, Hanson J, Weiss WP. Tebbe AW, et al. Among authors: weiss wp. J Dairy Sci. 2021 Jul;104(7):7888-7901. doi: 10.3168/jds.2021-20176. Epub 2021 Apr 2. J Dairy Sci. 2021. PMID: 33814155 Free article.
After parturition, dairy cows mobilize AA from skeletal muscle to meet metabolizable protein (MP) requirements. High mobilization may compromise cow health and longer-term milk production. Postpartum diets with higher MP concentrations, improved AA profiles, or MP increase …
After parturition, dairy cows mobilize AA from skeletal muscle to meet metabolizable protein (MP) requirements. High mobilization may compro …
Concurrent and carryover effects of feeding blends of protein and amino acids in high-protein diets with different concentrations of forage fiber to fresh cows. 1. Production and blood metabolites.
Tebbe AW, Weiss WP. Tebbe AW, et al. Among authors: weiss wp. J Dairy Sci. 2021 May;104(5):5583-5600. doi: 10.3168/jds.2020-19663. Epub 2021 Mar 2. J Dairy Sci. 2021. PMID: 33663852 Free article.
Overall, feeding blends of RUP and AA may improve the balance of AA for fresh cows fed high MP diets and improve concurrent and longer-term milk production in multiparous cows. However, with high MP diets, multiparous fresh cows require greater concentrations of fNDF than …
Overall, feeding blends of RUP and AA may improve the balance of AA for fresh cows fed high MP diets and improve concurrent and longer-te …
Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort.
de Medeiros CB, Moxon-Emre I, Scantlebury N, Malkin D, Ramaswamy V, Decker A, Law N, Kumabe T, Leonard J, Rubin J, Jung S, Kim SK, Gupta N, Weiss W, Faria CC, Vibhakar R, Lafay-Cousin L, Chan J, Kros JM, Janzen L, Taylor MD, Bouffet E, Mabbott DJ. de Medeiros CB, et al. Among authors: weiss w. Cancer Med. 2020 Jan;9(2):447-459. doi: 10.1002/cam4.2701. Epub 2019 Nov 21. Cancer Med. 2020. PMID: 31755223 Free PMC article.
This is a critical first step in developing global standards for evaluating long-term outcomes....
This is a critical first step in developing global standards for evaluating long-term outcomes....
Predictions of ruminal outflow of essential amino acids in dairy cattle.
Fleming AJ, Lapierre H, White RR, Tran H, Kononoff PJ, Martineau R, Weiss WP, Hanigan MD. Fleming AJ, et al. Among authors: weiss wp. J Dairy Sci. 2019 Dec;102(12):10947-10963. doi: 10.3168/jds.2019-16301. Epub 2019 Nov 6. J Dairy Sci. 2019. PMID: 31704011 Free article.
These included regressions of (1) residual errors for predicted EAA flows on each of the 3 protein-driven EA flows, (2) observed EAA flows on each protein-driven EAA flow, including an intercept, (3) observed EAA flows on the protein-driven EAA flows, excluding an intercept te …
These included regressions of (1) residual errors for predicted EAA flows on each of the 3 protein-driven EA flows, (2) observed EAA flows o …
Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge.
Hansen SG, Womack J, Scholz I, Renner A, Edgel KA, Xu G, Ford JC, Grey M, St Laurent B, Turner JM, Planer S, Legasse AW, Richie TL, Aguiar JC, Axthelm MK, Villasante ED, Weiss W, Edlefsen PT, Picker LJ, Früh K. Hansen SG, et al. Among authors: weiss w. PLoS One. 2019 Jan 23;14(1):e0210252. doi: 10.1371/journal.pone.0210252. eCollection 2019. PLoS One. 2019. PMID: 30673723 Free PMC article.
While sporozoite vaccines targeting the pre-erythrocytic stage show great promise, it has not been possible to maintain efficacy long-term, likely due to an inability of these vaccines to maintain effector memory T cell responses in the liver. ...
While sporozoite vaccines targeting the pre-erythrocytic stage show great promise, it has not been possible to maintain efficacy long-ter …
66 results