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Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.
Kilic A, Halu A, De Marzio M, Maiorino E, Duvall MG, Bruggemann TR, Rojas Quintero JJ, Chase R, Mirzakhani H, Sungur AÖ, Koepke J, Nakano T, Peh HY, Krishnamoorthy N, Abdulnour RE, Georgopoulos K, Litonjua AA, Demay M, Renz H, Levy BD, Weiss ST. Kilic A, et al. Among authors: weiss st. Elife. 2024 Apr 3;12:RP89270. doi: 10.7554/eLife.89270. Elife. 2024. PMID: 38567749 Free PMC article.
Vitamin D deficiency caused severe lung inflammation after allergen challenge in mice that was prevented by long-term prenatal vitamin D supplementation. Mechanistically, vitamin D induced the expression of the Ikzf3-encoded protein Aiolos to suppress IL-2 signaling and am …
Vitamin D deficiency caused severe lung inflammation after allergen challenge in mice that was prevented by long-term prenatal vitami …
Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.
Mendez KM, Begum S, Tiwari A, Sharma R, Chen Q, Kelly RS, Prince N, Huang M, Kachroo P, Chu SH, Chen Y, Lee-Sarwar K, Broadhurst DI, Reinke SN, Gerszten R, Clish C, Avila L, Celedón JC, Wheelock CE, Weiss ST, McGeachie M, Lasky-Su JA. Mendez KM, et al. Among authors: weiss st. EBioMedicine. 2024 Apr;102:105025. doi: 10.1016/j.ebiom.2024.105025. Epub 2024 Mar 7. EBioMedicine. 2024. PMID: 38458111 Free PMC article.
BACKGROUND: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between …
BACKGROUND: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there i …
A novel piwi-interacting RNA associates with type 2-high asthma phenotypes.
Li J, Hong X, Jiang M, Kho AT, Tiwari A, Wang AL, Chase RP, Celedón JC, Weiss ST, McGeachie MJ, Tantisira KG. Li J, et al. Among authors: weiss st. J Allergy Clin Immunol. 2024 Mar;153(3):695-704. doi: 10.1016/j.jaci.2023.10.032. Epub 2023 Dec 4. J Allergy Clin Immunol. 2024. PMID: 38056635
Linear regression was used for the association analysis of piRNAs and peripheral blood eosinophil count, total serum IgE level, and long-term asthma exacerbation in children with asthma. Mediation analysis was performed to investigate the effect direction. ...All 22 signif …
Linear regression was used for the association analysis of piRNAs and peripheral blood eosinophil count, total serum IgE level, and long- …
Early life gut microbiome in children following spontaneous preterm birth and maternal preeclampsia.
Shadid ILC, Lee-Sarwar K, Lu Z, Yadama A, Laranjo N, Carey V, O'Connor GT, Zeiger RS, Bacharier L, Guchelaar HJ, Liu YY, Litonjua AA, Weiss ST, Mirzakhani H. Shadid ILC, et al. Among authors: weiss st. iScience. 2023 Oct 28;26(12):108311. doi: 10.1016/j.isci.2023.108311. eCollection 2023 Dec 15. iScience. 2023. PMID: 38025771 Free PMC article.
The early life microbiome plays an important role in developmental and long-term health outcomes. However, it is unknown whether adverse pregnancy complications affect the offspring's gut microbiome postnatally and in early years. ...The implications of these findings on t …
The early life microbiome plays an important role in developmental and long-term health outcomes. However, it is unknown whether adve …
Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.
Knihtilä HM, Kachroo P, Shadid I, Raissadati A, Peng C, McElrath TF, Litonjua AA, Demeo DL, Loscalzo J, Weiss ST, Mirzakhani H. Knihtilä HM, et al. Among authors: weiss st. EBioMedicine. 2023 Dec;98:104890. doi: 10.1016/j.ebiom.2023.104890. Epub 2023 Nov 22. EBioMedicine. 2023. PMID: 37995466 Free PMC article.
The association of these cord blood DNA methylation signatures with offspring's long-term morbidities due to preeclampsia should be further investigated. ...
The association of these cord blood DNA methylation signatures with offspring's long-term morbidities due to preeclampsia should be f …
ACMT Position Statement: End the Use of the Term "Excited Delirium".
Stolbach AI, Dargan PI, Greller HA, Hamilton RJ, Johnson-Arbor K, Murray BP, Ovakim D, Tormoehlen L, Nelson LS; Collaborators. Stolbach AI, et al. J Med Toxicol. 2023 Jul;19(3):310-312. doi: 10.1007/s13181-023-00944-4. Epub 2023 Jun 22. J Med Toxicol. 2023. PMID: 37349654 No abstract available.
Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.
Rosenberg L, Liu C, Sharma R, Wood C, Vyhlidal CA, Gaedigk R, Kho AT, Ziniti JP, Celedón JC, Tantisira KG, Weiss ST, McGeachie MJ, Kechris K, Sharma S. Rosenberg L, et al. Among authors: weiss st. Int J Mol Sci. 2023 Apr 23;24(9):7727. doi: 10.3390/ijms24097727. Int J Mol Sci. 2023. PMID: 37175432 Free PMC article.
We also considered the above model with an additional sex-by-IUS interaction term, allowing IUS effects to differ by male and female samples. ...
We also considered the above model with an additional sex-by-IUS interaction term, allowing IUS effects to differ by male and female …
Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm.
McGowan EC, McGrath M, Law A, O'Shea TM, Aschner JL, Blackwell CK, Fry RC, Ganiban JM, Higgins R, Margolis A, Sathyanarayana S, Taylor G, Alshawabkeh AN, Cordero JF, Spillane NT, Hudak ML, Camargo CA Jr, Dabelea D, Dunlop AL, Elliott AJ, Ferrara AM, Talavera-Barber M, Singh AM, Karagas MR, Karr C, O'Connor TG, Paneth N, Wright RJ, Wright RO, Cowell W, Stanford JB, Bendixsen C, Lester BM; program collaborators for Environmental Influences on Child Health Outcomes (ECHO). McGowan EC, et al. JAMA Netw Open. 2023 Apr 3;6(4):e2310696. doi: 10.1001/jamanetworkopen.2023.10696. JAMA Netw Open. 2023. PMID: 37115545 Free PMC article.
Individuals born preterm vs term (37 weeks' gestation) and differences among preterm subgroups of individuals (<28 weeks', 28-36 weeks' vs 37 weeks' gestation) were assessed. ...RESULTS: Data from 1691 children and young adults were analyzed; among 270 individuals born …
Individuals born preterm vs term (37 weeks' gestation) and differences among preterm subgroups of individuals (<28 weeks', 28-36 w …
Early-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring.
Shah J, Shadid ILC, Carey VJ, Laranjo N, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST, Mirzakhani H. Shah J, et al. Among authors: weiss st. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2125-2132.e1. doi: 10.1016/j.jaip.2023.03.059. Epub 2023 Apr 23. J Allergy Clin Immunol Pract. 2023. PMID: 37088369
BACKGROUND: Excessive weight is associated with the development of childhood asthma. However, trends among preterm and term offspring may differ. OBJECTIVE: To assess whether the association of longitudinal weight for age (WFA) and odds of asthma/recurrent wheeze in early …
BACKGROUND: Excessive weight is associated with the development of childhood asthma. However, trends among preterm and term offspring …
The Association of Prenatal C-Reactive Protein and Interleukin-8 Levels with Maternal Characteristics and Preterm Birth.
Chen YS, Mirzakhani H, Knihtilä H, Fichorova RN, Luu N, Laranjo N, Jha A, Kelly RS, Weiss ST, Litonjua AA, Lee-Sarwar KA. Chen YS, et al. Among authors: weiss st. Am J Perinatol. 2022 Dec 7:10.1055/a-1961-2425. doi: 10.1055/a-1961-2425. Online ahead of print. Am J Perinatol. 2022. PMID: 36241210
A subgroup analysis comparing only those with a spontaneous preterm birth phenotype to those with term birth was also performed. RESULTS: Maternal characteristics including lower educational attainment, higher prepregnancy body mass index, gestational diabete …
A subgroup analysis comparing only those with a spontaneous preterm birth phenotype to those with term birth was also p …
51 results