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Trained innate immunity modulates osteoblast and osteoclast differentiation.
Rahmani NR, Belluomo R, Kruyt MC, Gawlitta D, Joosten LAB, Weinans H, Croes M. Rahmani NR, et al. Among authors: weinans h. Stem Cell Rev Rep. 2024 Mar 13. doi: 10.1007/s12015-024-10711-9. Online ahead of print. Stem Cell Rev Rep. 2024. PMID: 38478316
Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or re …
Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metab …
Acetabular rim extension using a personalized titanium implant for treatment of hip dysplasia in dogs: short-term results.
Kwananocha I, Magré J, Willemsen K, Weinans H, Sakkers RJB, How T, Verseijden F, Tryfonidou MA, van der Wal BCH, Meij BP. Kwananocha I, et al. Among authors: weinans h. Front Vet Sci. 2023 Apr 20;10:1160177. doi: 10.3389/fvets.2023.1160177. eCollection 2023. Front Vet Sci. 2023. PMID: 37152693 Free PMC article.
The force plate showed no significant improvement during the 3 months follow-up. Although pain reduction by the implant was unclear in short-term results, a personalized shelf implant significantly increased femoral head coverage and eliminated subluxation of the dysplasti …
The force plate showed no significant improvement during the 3 months follow-up. Although pain reduction by the implant was unclear in short …
A mean 4-year evaluation of infection control rates of hip and knee prosthetic joint infection-related revision arthroplasty: an observational study.
Van Dijk B, Nurmohamed FRHA, Hooning van Duijvenbode JFF, Veltman ES, Rentenaar RJ, Weinans H, Vogely HC, Van der Wal BCH. Van Dijk B, et al. Among authors: weinans h. Acta Orthop. 2022 Jul 13;93:652-657. doi: 10.2340/17453674.2022.3975. Acta Orthop. 2022. PMID: 35848729 Free PMC article.
BACKGROUND AND PURPOSE: The long-term results of the 1- or 2-stage revision procedure and infection-free prosthesis survival in a tertiary referral center are unknown. In this retrospective observational study, the long-term results of infection control and infectio …
BACKGROUND AND PURPOSE: The long-term results of the 1- or 2-stage revision procedure and infection-free prosthesis survival in a ter …
Good long-term outcomes of the hip Chiari osteotomy in adolescents and adults with hip dysplasia: a systematic review.
Willemsen K, Niemeyer MJS, Harlianto NI, Sadiqi S, Seevinck PR, Sakkers RJB, Weinans H, Van der Wal BCH. Willemsen K, et al. Among authors: weinans h. Acta Orthop. 2022 Feb 4;93:296-302. doi: 10.2340/17453674.2022.2031. Acta Orthop. 2022. PMID: 35129201 Free PMC article.
BACKGROUND AND PURPOSE: The Chiari osteotomy was a regular treatment for developmental hip dysplasia before it became mostly reserved as a salvage therapy. However, the long-term survival of the Chiari osteotomy has not been systematically investigated. ...
BACKGROUND AND PURPOSE: The Chiari osteotomy was a regular treatment for developmental hip dysplasia before it became mostly reserved as a s …
Statistical Shape Modeling of US Images to Predict Hip Dysplasia Development in Infants.
Bonsel JM, Gielis WP, Pollet V, Weinans HH, Sakkers RJB. Bonsel JM, et al. Among authors: weinans hh. Radiology. 2022 May;303(2):425-432. doi: 10.1148/radiol.211057. Epub 2022 Jan 25. Radiology. 2022. PMID: 35076302 Clinical Trial.
With multivariable logistic regression adjusted for infant sex and treatment (Pavlik harness treatment vs active observation), shape modes were correlated with the outcomes of persistent hip dysplasia on US images (alpha angle <60) after 12-week follow-up and residual hip dysp …
With multivariable logistic regression adjusted for infant sex and treatment (Pavlik harness treatment vs active observation), shape modes w …
Additively manufactured space-filling meta-implants.
Kolken HMA, de Jonge CP, van der Sloten T, Garcia AF, Pouran B, Willemsen K, Weinans H, Zadpoor AA. Kolken HMA, et al. Among authors: weinans h. Acta Biomater. 2021 Apr 15;125:345-357. doi: 10.1016/j.actbio.2021.02.020. Epub 2021 Feb 19. Acta Biomater. 2021. PMID: 33618018 Free article.
Due to the severe bone deficiencies and poor bone quality, it can be very challenging to acquire adequate initial implant stability and long-term fixation. More advanced treatments, such as patient-specific implants, do guarantee the initial stability, but are formidably e …
Due to the severe bone deficiencies and poor bone quality, it can be very challenging to acquire adequate initial implant stability and long …
Treating infections with ionizing radiation: a historical perspective and emerging techniques.
van Dijk B, Lemans JVC, Hoogendoorn RM, Dadachova E, de Klerk JMH, Vogely HC, Weinans H, Lam MGEH, van der Wal BCH. van Dijk B, et al. Among authors: weinans h. Antimicrob Resist Infect Control. 2020 Jul 31;9(1):121. doi: 10.1186/s13756-020-00775-w. Antimicrob Resist Infect Control. 2020. PMID: 32736656 Free PMC article. Review.
In some cases, external radiation therapy decreased the mortality significantly but long-term follow-up of the patients was often not performed so long term radiation effects, as well as potential increased risk of malignancies could not be investigated. ...
In some cases, external radiation therapy decreased the mortality significantly but long-term follow-up of the patients was often not …
Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data.
Widera P, Welsing PMJ, Ladel C, Loughlin J, Lafeber FPFJ, Petit Dop F, Larkin J, Weinans H, Mobasheri A, Bacardit J. Widera P, et al. Among authors: weinans h. Sci Rep. 2020 May 21;10(1):8427. doi: 10.1038/s41598-020-64643-8. Sci Rep. 2020. PMID: 32439879 Free PMC article.
In this article, we formulated the patient selection problem as a multi-class classification task, with classes based on clinically relevant measures of progression (over a time scale typical for clinical trials). Using data from two long-term knee osteoarthritis studies O …
In this article, we formulated the patient selection problem as a multi-class classification task, with classes based on clinically relevant …
A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model.
Korthagen NM, Brommer H, Hermsen G, Plomp SGM, Melsom G, Coeleveld K, Mastbergen SC, Weinans H, van Buul W, van Weeren PR. Korthagen NM, et al. Among authors: weinans h. Vet J. 2019 Sep;251:105340. doi: 10.1016/j.tvjl.2019.105340. Epub 2019 Jul 20. Vet J. 2019. PMID: 31492385
This approach therefore resolves a number of issues related to scaffold-based cartilage repair and compares favourably with results of several other studies in large animal models. However, long-term follow-up is needed to evaluate the true potential of this type of implan …
This approach therefore resolves a number of issues related to scaffold-based cartilage repair and compares favourably with results of sever …
39 results