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Osteogenesis and osteoclast inhibition in rheumatoid arthritis patients treated with bisphosphonates alone or in combination with pitavastatin over an 18-month follow-up after more than 4 years of treatment with bisphosphonates.
Nagashima M, Takahashi H, Shimane K, Nagase Y, Wauke K. Nagashima M, et al. Among authors: wauke k. Arthritis Res Ther. 2012 Oct 18;14(5):R224. doi: 10.1186/ar4063. Arthritis Res Ther. 2012. PMID: 23079134 Free PMC article.
CONCLUSION: Our findings suggest that both bone resorption and bone formation were inhibited by long-term administration of Bis alone, whereas combination therapy with Bis + statin may be associated with a less marked inhibition of bone metabolism. ...
CONCLUSION: Our findings suggest that both bone resorption and bone formation were inhibited by long-term administration of Bis alone …