Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia.
Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP.
Smith NM, et al. Among authors: wasserman ga.
Mucosal Immunol. 2018 Jan;11(1):220-235. doi: 10.1038/mi.2017.43. Epub 2017 May 17.
Mucosal Immunol. 2018.
PMID: 28513594
Free PMC article.
Previous pneumococcal infections provided protection against a heterotypic, highly virulent pneumococcus, as evidenced by reduced bacterial burdens and long-term sterilizing immunity. This protection was diminished by depletion of CD4(+) cells prior to the final infection. …
Previous pneumococcal infections provided protection against a heterotypic, highly virulent pneumococcus, as evidenced by reduced bacterial …