ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates.
Akers J, Bothe A, Suh H, Jung C, Stolp Z, Ghosh T, Yan L, Wang Y, Grismer T, Reyes A, Hu T, Xu S, Ban N, Kostova K.
Akers J, et al. Among authors: wang y.
bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591394. doi: 10.1101/2024.04.26.591394.
bioRxiv. 2024.
PMID: 38746087
Free PMC article.
Preprint.
We identified ZNF574 as a key component of a novel quality control pathway, which we term the Ribosome Assembly Surveillance Pathway (RASP). Loss of ZNF574 results in the accumulation of faulty biogenesis intermediates that interfere with global ribosome production, furthe …
We identified ZNF574 as a key component of a novel quality control pathway, which we term the Ribosome Assembly Surveillance Pathway …