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Tau and Amyloid beta Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.
Ondrejcak T, Klyubin I, Hu NW, O'Malley TT, Corbett GT, Winters R, Perkinton MS, Billinton A, Prenderville JA, Walsh DM, Rowan MJ. Ondrejcak T, et al. Among authors: walsh dm. J Neurosci. 2023 Aug 9;43(32):5870-5879. doi: 10.1523/JNEUROSCI.0082-23.2023. Epub 2023 Jul 25. J Neurosci. 2023. PMID: 37491315 Free PMC article.
Aqueous extracts of certain AD brains acutely inhibited long-term potentiation (LTP) of synaptic transmission in a manner that required both Abeta and tau. ...
Aqueous extracts of certain AD brains acutely inhibited long-term potentiation (LTP) of synaptic transmission in a manner that requir …
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.
Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Wang Z, et al. Among authors: walsh dm. Acta Neuropathol Commun. 2023 Mar 10;11(1):39. doi: 10.1186/s40478-023-01511-2. Acta Neuropathol Commun. 2023. PMID: 36899414 Free PMC article.
Here we show that activity in this bioassay agrees relatively well with disruption of hippocampal long-term potentiation, a correlate of learning and memory, and that measurement of neurotoxic oAbeta can be obscured by more abundant non-toxic forms of Abeta. ...
Here we show that activity in this bioassay agrees relatively well with disruption of hippocampal long-term potentiation, a correlate …
The effect of different grazing conditions on the insulin and incretin response to the oral glucose test in ponies.
Fitzgerald DM, Pollitt CC, Walsh DM, Sillence MN, de Laat MA. Fitzgerald DM, et al. Among authors: walsh dm. BMC Vet Res. 2019 Oct 16;15(1):345. doi: 10.1186/s12917-019-2088-1. BMC Vet Res. 2019. PMID: 31619223 Free PMC article.
This study aimed to determine whether the insulin and incretin responses to an OGT in ponies differed after short-term access to fertilised pasture, compared to unfertilised pasture, by using a randomised, repeated measures study design. ...
This study aimed to determine whether the insulin and incretin responses to an OGT in ponies differed after short-term access to fert …
A vicious cycle of β amyloid-dependent neuronal hyperactivation.
Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. Zott B, et al. Among authors: walsh dm. Science. 2019 Aug 9;365(6453):559-565. doi: 10.1126/science.aay0198. Science. 2019. PMID: 31395777 Free PMC article.
Soluble tau aggregates inhibit synaptic long-term depression and amyloid beta-facilitated LTD in vivo.
Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ. Ondrejcak T, et al. Among authors: walsh dm. Neurobiol Dis. 2019 Jul;127:582-590. doi: 10.1016/j.nbd.2019.03.022. Epub 2019 Mar 22. Neurobiol Dis. 2019. PMID: 30910746
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid beta-protein (Ass) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechanisms, including long- …
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid beta-protein (Ass) and tau, have rapid and …
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ. Ondrejcak T, et al. Among authors: walsh dm. J Neurosci. 2018 Dec 12;38(50):10595-10606. doi: 10.1523/JNEUROSCI.1700-18.2018. Epub 2018 Oct 24. J Neurosci. 2018. PMID: 30355631 Free PMC article.
Here we investigated the effect of different tau species on synaptic plasticity in the male rat hippocampus in vivo Intracerebroventricular injection of soluble aggregates formed from either wild-type or P301S human recombinant tau potently inhibited hippocampal long-term …
Here we investigated the effect of different tau species on synaptic plasticity in the male rat hippocampus in vivo Intracerebroventricular …
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. El Fatimy R, et al. Among authors: walsh dm. Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7. Acta Neuropathol. 2018. PMID: 29982852 Free PMC article.
Similarly, miR-132 attenuates PHF-Tau pathology and neurodegeneration, and enhances long-term potentiation in the P301S Tau transgenic mice. The neuroprotective effects are mediated by direct regulation of the Tau modifiers acetyltransferase EP300, kinase GSK3beta, RNA-bin …
Similarly, miR-132 attenuates PHF-Tau pathology and neurodegeneration, and enhances long-term potentiation in the P301S Tau transgeni …
Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.
Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ. Hu NW, et al. Among authors: walsh dm. Cell Rep. 2018 May 15;23(7):1932-1938. doi: 10.1016/j.celrep.2018.04.040. Cell Rep. 2018. PMID: 29768194 Free PMC article.
When introduced into the rat brain, secretomes from human neurons with either a presenilin-1 mutation, amyloid precursor protein duplication, or trisomy of chromosome 21 all strongly inhibit hippocampal long-term potentiation. Synaptic dysfunction caused by presenilin-1 mu …
When introduced into the rat brain, secretomes from human neurons with either a presenilin-1 mutation, amyloid precursor protein duplication …
Electronic Health Physical Activity Behavior Change Intervention to Self-Manage Cardiovascular Disease: Qualitative Exploration of Patient and Health Professional Requirements.
Walsh DM, Moran K, Cornelissen V, Buys R, Cornelis N, Woods C. Walsh DM, et al. J Med Internet Res. 2018 May 8;20(5):e163. doi: 10.2196/jmir.9181. J Med Internet Res. 2018. PMID: 29739740 Free article.
Uptake of traditional cardiac rehabilitation remains suboptimal, as attendance at formal hospital-based cardiac rehabilitation programs is low, with community-based cardiac rehabilitation rates and individual long-term exercise maintenance even lower. Home-based cardiac re …
Uptake of traditional cardiac rehabilitation remains suboptimal, as attendance at formal hospital-based cardiac rehabilitation programs is l …
44 results