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A Phase 3, open-label, 96-week trial to study the safety, tolerability, and efficacy of tezacaftor/ivacaftor in children ≥ 6 years of age homozygous for F508del or heterozygous for F508del and a residual function CFTR variant.
Sawicki GS, Chilvers M, McNamara J, Naehrlich L, Saunders C, Sermet-Gaudelus I, Wainwright CE, Ahluwalia N, Campbell D, Harris RS, Paz-Diaz H, Shih JL, Davies JC. Sawicki GS, et al. Among authors: wainwright ce. J Cyst Fibros. 2022 Jul;21(4):675-683. doi: 10.1016/j.jcf.2022.02.003. Epub 2022 Feb 18. J Cyst Fibros. 2022. PMID: 35190292 Free article. Clinical Trial.
CONCLUSIONS: Tezacaftor/ivacaftor is generally safe and well tolerated, and treatment effects are maintained for up to 120 weeks. These results support long-term use of tezacaftor/ivacaftor in children 6 years of age with CF and F/F or F/RF genotypes....
CONCLUSIONS: Tezacaftor/ivacaftor is generally safe and well tolerated, and treatment effects are maintained for up to 120 weeks. These resu …
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Among authors: wainwright ce. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Climatic drivers of (changes in) bat migration phenology at Bracken Cave (USA).
Haest B, Stepanian PM, Wainwright CE, Liechti F, Bauer S. Haest B, et al. Among authors: wainwright ce. Glob Chang Biol. 2021 Feb;27(4):768-780. doi: 10.1111/gcb.15433. Epub 2020 Nov 19. Glob Chang Biol. 2021. PMID: 33151018
For other animal taxa, the current understanding of, and evidence for, climate (change) influences on migration still remains rather limited, mainly due to the lack of long-term phenology datasets. Bracken Cave in Texas (USA) holds one of the largest bat colonies of the wo …
For other animal taxa, the current understanding of, and evidence for, climate (change) influences on migration still remains rather limited …
Centralised versus outreach models of cystic fibrosis care should be tailored to the needs of the individual patient.
Geake J, Ballard E, O'Rourke P, Wainwright CE, Reid DW, Bell SC. Geake J, et al. Among authors: wainwright ce. Intern Med J. 2020 Feb;50(2):232-235. doi: 10.1111/imj.14724. Intern Med J. 2020. PMID: 32037704
For patients living in regional/remote Australia, accessing such services may be a challenge. Here, we describe long-term outcomes for CF patients according to their access to specialist CF centre care in childhood....
For patients living in regional/remote Australia, accessing such services may be a challenge. Here, we describe long-term outcomes fo …
Declines in an abundant aquatic insect, the burrowing mayfly, across major North American waterways.
Stepanian PM, Entrekin SA, Wainwright CE, Mirkovic D, Tank JL, Kelly JF. Stepanian PM, et al. Among authors: wainwright ce. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2987-2992. doi: 10.1073/pnas.1913598117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964842 Free PMC article.
We analyzed radar observations of mayfly emergence flights to quantify long-term changes in annual biomass transport along the Upper Mississippi River and Western Lake Erie Basin. ...
We analyzed radar observations of mayfly emergence flights to quantify long-term changes in annual biomass transport along the Upper …
Ongoing changes in migration phenology and winter residency at Bracken Bat Cave.
Stepanian PM, Wainwright CE. Stepanian PM, et al. Among authors: wainwright ce. Glob Chang Biol. 2018 Jul;24(7):3266-3275. doi: 10.1111/gcb.14051. Epub 2018 Feb 14. Glob Chang Biol. 2018. PMID: 29442413
Some of the world's largest bat populations occur during the summer in the south-central United States, when millions of pregnant females migrate from lower latitudes to give birth in communal maternity colonies. Despite a relatively large volume of research into these col …
Some of the world's largest bat populations occur during the summer in the south-central United States, when millions of pregnant females mi …
Recovery of lung function following a pulmonary exacerbation in patients with cystic fibrosis and the G551D-CFTR mutation treated with ivacaftor.
Flume PA, Wainwright CE, Elizabeth Tullis D, Rodriguez S, Niknian M, Higgins M, Davies JC, Wagener JS. Flume PA, et al. Among authors: wainwright ce. J Cyst Fibros. 2018 Jan;17(1):83-88. doi: 10.1016/j.jcf.2017.06.002. Epub 2017 Jun 24. J Cyst Fibros. 2018. PMID: 28651844 Free article.
Short-term recovery was measured 2 to 8weeks after treatment, and long-term recovery was determined at the end-of-study, both compared with baseline measured just prior to the PEx. RESULTS: Fewer patients receiving ivacaftor experienced a PEx than patients receiving …
Short-term recovery was measured 2 to 8weeks after treatment, and long-term recovery was determined at the end-of-study, both …
A Novel Method and Its Application to Measuring Pathogen Decay in Bioaerosols from Patients with Respiratory Disease.
Johnson GR, Knibbs LD, Kidd TJ, Wainwright CE, Wood ME, Ramsay KA, Bell SC, Morawska L. Johnson GR, et al. Among authors: wainwright ce. PLoS One. 2016 Jul 7;11(7):e0158763. doi: 10.1371/journal.pone.0158763. eCollection 2016. PLoS One. 2016. PMID: 27388489 Free PMC article.
This work aimed to develop an in vivo approach for measuring the duration of human bioaerosol infectivity. To achieve this, techniques designed to target short-term and long-term bioaerosol aging, were combined in a tandem system and optimized for the collection of …
This work aimed to develop an in vivo approach for measuring the duration of human bioaerosol infectivity. To achieve this, techniques desig …