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Chronic ketamine administration modulates midbrain dopamine system in mice.
Tan S, Lam WP, Wai MS, Yu WH, Yew DT. Tan S, et al. Among authors: wai ms. PLoS One. 2012;7(8):e43947. doi: 10.1371/journal.pone.0043947. Epub 2012 Aug 24. PLoS One. 2012. PMID: 22937133 Free PMC article.
However, ketamine did not affect the expression of genes involved in DA synthesis. In the long-term (3 months) ketamine treated mice, significant increases of DA contents were found in the midbrain. ...Using western blotting, significant increases in BDNF protein levels we …
However, ketamine did not affect the expression of genes involved in DA synthesis. In the long-term (3 months) ketamine treated mice, …
Long term ketamine and ketamine plus alcohol toxicity - what can we learn from animal models?
Wai MS, Luan P, Jiang Y, Chan WM, Tsui TY, Tang HC, Lam WP, Fan M, Yew DT. Wai MS, et al. Mini Rev Med Chem. 2013 Feb;13(2):273-9. doi: 10.2174/1389557511313020009. Mini Rev Med Chem. 2013. PMID: 22512581 Review.
Cerebellum was found to be down-regulated in both mice and humans after long-term of ketamine administration and it was caused by the apoptosis of Purkinje cells. Deleterious effects in other organs reported in long-term ketamine users include of kidney dysfunction …
Cerebellum was found to be down-regulated in both mice and humans after long-term of ketamine administration and it was caused by the …
Long-term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney.
Wai MS, Chan WM, Zhang AQ, Wu Y, Yew DT. Wai MS, et al. Hum Exp Toxicol. 2012 Sep;31(9):877-86. doi: 10.1177/0960327112436404. Epub 2012 Feb 21. Hum Exp Toxicol. 2012. PMID: 22354085
Hydropic degenerations of the kidney tubules were observed as early as 6 weeks of treatment. Long-term ketamine administration (28 weeks) led to atresia of glomeruli in the kidney. ...
Hydropic degenerations of the kidney tubules were observed as early as 6 weeks of treatment. Long-term ketamine administration (28 we …
Cardiotoxicity induced in mice by long term ketamine and ketamine plus alcohol treatment.
Chan WM, Liang Y, Wai MS, Hung AS, Yew DT. Chan WM, et al. Among authors: wai ms. Toxicol Lett. 2011 Nov 30;207(2):191-6. doi: 10.1016/j.toxlet.2011.09.008. Epub 2011 Sep 16. Toxicol Lett. 2011. PMID: 21945864
Although its toxicity on the central nervous system (CNS) and urinary system had been reported, its potential adverse effects on the heart is still not addressed. Using our long term ketamine addiction model in which, 1-month-old ICR mice were given ketamine intraperitonea …
Although its toxicity on the central nervous system (CNS) and urinary system had been reported, its potential adverse effects on the heart i …
Ketamine effects on the urogenital system--changes in the urinary bladder and sperm motility.
Tan S, Chan WM, Wai MS, Hui LK, Hui VW, James AE, Yeung LY, Yew DT. Tan S, et al. Among authors: wai ms. Microsc Res Tech. 2011 Dec;74(12):1192-8. doi: 10.1002/jemt.21014. Epub 2011 May 11. Microsc Res Tech. 2011. PMID: 21563274
Subsequently, 30 mg/kg was used as the dose for the study in the toxicity of long-term ketamine administration on urinary bladder and sperm motility. ...
Subsequently, 30 mg/kg was used as the dose for the study in the toxicity of long-term ketamine administration on urinary bladder and …
Permanent deficits in brain functions caused by long-term ketamine treatment in mice.
Sun L, Lam WP, Wong YW, Lam LH, Tang HC, Wai MS, Mak YT, Pan F, Yew DT. Sun L, et al. Among authors: wai ms. Hum Exp Toxicol. 2011 Sep;30(9):1287-96. doi: 10.1177/0960327110388958. Epub 2010 Nov 5. Hum Exp Toxicol. 2011. PMID: 21056951
Ketamine is a non-competitive antagonist of N-methyl-d-aspartate receptor, which plays important roles in synaptic plasticity and neuronal learning. Most previous studies have examined the immediate and short-term effects of ketamine, which include learning and cognitive d …
Ketamine is a non-competitive antagonist of N-methyl-d-aspartate receptor, which plays important roles in synaptic plasticity and neuronal l …
Hyperphosphorylated tau in the brains of mice and monkeys with long-term administration of ketamine.
Yeung LY, Wai MS, Fan M, Mak YT, Lam WP, Li Z, Lu G, Yew DT. Yeung LY, et al. Among authors: wai ms. Toxicol Lett. 2010 Mar 15;193(2):189-93. doi: 10.1016/j.toxlet.2010.01.008. Epub 2010 Jan 20. Toxicol Lett. 2010. PMID: 20093173
Hyperphosphorylation of tau is an early event in the aging process and Alzheimer's disease. Therefore, we aimed to find out whether long-term ketmaine administration is related to hyperphosphorylation of tau or not in the brains of mice and monkeys. ...Furthermore, about 1 …
Hyperphosphorylation of tau is an early event in the aging process and Alzheimer's disease. Therefore, we aimed to find out whether long- …
Vagus, hypoglossal, and median nerves in human development.
Liang Y, Fang M, Li J, Wai MS, Lam WP, Yew DT. Liang Y, et al. Among authors: wai ms. Int J Neurosci. 2007 Apr;117(4):453-64. doi: 10.1080/00207450600773244. Int J Neurosci. 2007. PMID: 17365128
The article reports the changes in the vagus, hypoglossal, and median nerves in the fetus and term babies. The changes of proportion of different-sized nerve fibers are documented. ...
The article reports the changes in the vagus, hypoglossal, and median nerves in the fetus and term babies. The changes of proportion …