Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis.
Chan DCH, Xu J, Vujovic A, Wong N, Gordon V, de Rooij LPMH, Moreira S, Joyce CE, La Rose J, Sandí MJ, Doble BW, Novina CD, Rottapel RK, Hope KJ.
Chan DCH, et al. Among authors: vujovic a.
Blood Adv. 2021 Aug 24;5(16):3120-3133. doi: 10.1182/bloodadvances.2020002539.
Blood Adv. 2021.
PMID: 34406376
Free PMC article.
We demonstrate that transplanted Arhgef2-/- fetal liver and bone marrow cells yield impaired hematopoietic recovery and a production deficit from long-term HSCs, phenotypes that are not the result of differences in numbers of transplanted HSCs, their cell cycle status, lev …
We demonstrate that transplanted Arhgef2-/- fetal liver and bone marrow cells yield impaired hematopoietic recovery and a production deficit …