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The thyroid axis 'setpoints' are significantly altered after long-term suppressive LT4 therapy.
Verburg FA, Mäder U, Grelle I, Visser TJ, Peeters RP, Smit JW, Reiners C. Verburg FA, et al. Among authors: visser tj. Horm Metab Res. 2014 Oct;46(11):794-9. doi: 10.1055/s-0034-1375678. Epub 2014 May 27. Horm Metab Res. 2014. PMID: 24867137
The aim of the study was to investigate the changes in the thyroid axis setpoint after long-term suppressive levothyroxine therapy for differentiated thyroid carcinoma and the resulting changes in levothyroxine requirement. ...As a result of changes in thyroid hormone meta …
The aim of the study was to investigate the changes in the thyroid axis setpoint after long-term suppressive levothyroxine therapy fo …
Thyroid hormone transporters and deiodinases in the developing human hypothalamus.
Friesema EC, Visser TJ, Borgers AJ, Kalsbeek A, Swaab DF, Fliers E, Alkemade A. Friesema EC, et al. Among authors: visser tj. Eur J Endocrinol. 2012 Sep;167(3):379-86. doi: 10.1530/EJE-12-0177. Epub 2012 Jun 21. Eur J Endocrinol. 2012. PMID: 22723621
RESULTS: We found MCT8 and D3 but not D2 protein expression to be present in our earliest sample of 17 weeks of gestation, indicating triiodothyronine degradation, but not production at this time of development. At term, expression of TH transporters and D2 decreased and D …
RESULTS: We found MCT8 and D3 but not D2 protein expression to be present in our earliest sample of 17 weeks of gestation, indicating triiod …
Changes within the thyroid axis after long-term TSH-suppressive levothyroxine therapy.
Verburg FA, Smit JW, Grelle I, Visser TJ, Peeters RP, Reiners C. Verburg FA, et al. Among authors: visser tj. Clin Endocrinol (Oxf). 2012 Apr;76(4):577-81. doi: 10.1111/j.1365-2265.2011.04262.x. Clin Endocrinol (Oxf). 2012. PMID: 22017394
OBJECTIVE: The effects of long-term TSH-suppressive levothyroxine (LT4) therapy on thyroid hormone metabolism in patients with differentiated thyroid carcinoma (DTC) are unknown. The aim of the study was to investigate the changes in thyroid hormone metabolism after long- …
OBJECTIVE: The effects of long-term TSH-suppressive levothyroxine (LT4) therapy on thyroid hormone metabolism in patients with differ …
Differential effects of maternal dexamethasone treatment on circulating thyroid hormone concentrations and tissue deiodinase activity in the pregnant ewe and fetus.
Forhead AJ, Jellyman JK, Gardner DS, Giussani DA, Kaptein E, Visser TJ, Fowden AL. Forhead AJ, et al. Among authors: visser tj. Endocrinology. 2007 Feb;148(2):800-5. doi: 10.1210/en.2006-1194. Epub 2006 Nov 16. Endocrinology. 2007. PMID: 17110425
This study investigated the effect of maternal dexamethasone treatment, in clinically relevant doses, on plasma thyroid hormone concentrations and tissue deiodinase activities (D1, D2, and D3) in ewes and their fetuses. From 125 d of gestation (term 145 +/- 2 d), pregnant …
This study investigated the effect of maternal dexamethasone treatment, in clinically relevant doses, on plasma thyroid hormone concentratio …
Long-term toxicity of [(177)Lu-DOTA (0),Tyr (3)]octreotate in rats.
Rolleman EJ, Krenning EP, Bernard BF, de Visser M, Bijster M, Visser TJ, Vermeij M, Lindemans J, de Jong M. Rolleman EJ, et al. Among authors: visser tj. Eur J Nucl Med Mol Imaging. 2007 Feb;34(2):219-27. doi: 10.1007/s00259-006-0232-1. Epub 2006 Sep 22. Eur J Nucl Med Mol Imaging. 2007. PMID: 17021812
The efficacy of PRRT is limited by uptake and retention in the proximal tubules of the kidney, which might lead to radiation nephropathy. We investigated the long-term renal toxicity after different doses of [(177)Lu-DOTA(0),Tyr(3)]octreotate and the effects of dose fracti …
The efficacy of PRRT is limited by uptake and retention in the proximal tubules of the kidney, which might lead to radiation nephropathy. We …
Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term.
Forhead AJ, Curtis K, Kaptein E, Visser TJ, Fowden AL. Forhead AJ, et al. Among authors: visser tj. Endocrinology. 2006 Dec;147(12):5988-94. doi: 10.1210/en.2006-0712. Epub 2006 Sep 7. Endocrinology. 2006. PMID: 16959839
Plasma cortisol and T3 concentrations in utero were manipulated by exogenous hormone infusion and fetal adrenalectomy. Between 130 and 144 d of gestation (term 145+/-2 d), maturational increments in plasma cortisol and T3, and D1 (hepatic, renal, perirenal adipose tissue) …
Plasma cortisol and T3 concentrations in utero were manipulated by exogenous hormone infusion and fetal adrenalectomy. Between 130 and 144 d …
Hormone levels in children during the first week of ICU-admission: is there an effect of adequate feeding?
Hulst JM, van Goudoever JB, Visser TJ, Tibboel D, Joosten KF. Hulst JM, et al. Among authors: visser tj. Clin Nutr. 2006 Feb;25(1):154-62. doi: 10.1016/j.clnu.2005.10.006. Epub 2005 Nov 15. Clin Nutr. 2006. PMID: 16297504
Levels of triiodothyronine (T3), reverse T3 (rT3), ratio T3/rT3 and insulin-like growth factor I (IGF-1) were evaluated in 84 critically ill children (50 term neonates and 34 children aged 32 d-15 yr) admitted to our multidisciplinary tertiary pediatric intensive care unit …
Levels of triiodothyronine (T3), reverse T3 (rT3), ratio T3/rT3 and insulin-like growth factor I (IGF-1) were evaluated in 84 critically ill …
Developmental trends in cord and postpartum serum thyroid hormones in preterm infants.
Williams FL, Simpson J, Delahunty C, Ogston SA, Bongers-Schokking JJ, Murphy N, van Toor H, Wu SY, Visser TJ, Hume R; Collaboration from the Scottish Preterm Thyroid Group. Williams FL, et al. Among authors: visser tj. J Clin Endocrinol Metab. 2004 Nov;89(11):5314-20. doi: 10.1210/jc.2004-0869. J Clin Endocrinol Metab. 2004. PMID: 15531476
In all preterm groups, TSH and rT(3) decrease to below, T(4)-binding globulin increases to within, and T(3) and T(4) sulfate increase to above cord levels of equivalent gestational age. Term infants are hyperthyroxinemic relative to cord and nonpregnant adult levels of T(4 …
In all preterm groups, TSH and rT(3) decrease to below, T(4)-binding globulin increases to within, and T(3) and T(4) sulfate increase to abo …
Human fetal and cord serum thyroid hormones: developmental trends and interrelationships.
Hume R, Simpson J, Delahunty C, van Toor H, Wu SY, Williams FL, Visser TJ; Scottish Preterm Thyroid Group. Hume R, et al. Among authors: visser tj. J Clin Endocrinol Metab. 2004 Aug;89(8):4097-103. doi: 10.1210/jc.2004-0573. J Clin Endocrinol Metab. 2004. PMID: 15292353
In cord and fetal serum, T(4), T(3), and TBG levels increase with gestation until term; TSH, FT4, T4S, and rT(3) levels increase and peak in the late second/early third trimester and then decline to term; T(4)/TBG ratios increase until late second trimester and plat …
In cord and fetal serum, T(4), T(3), and TBG levels increase with gestation until term; TSH, FT4, T4S, and rT(3) levels increase and …
27 results