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New approach methodologies in human regulatory toxicology - Not if, but how and when!
Schmeisser S, Miccoli A, von Bergen M, Berggren E, Braeuning A, Busch W, Desaintes C, Gourmelon A, Grafström R, Harrill J, Hartung T, Herzler M, Kass GEN, Kleinstreuer N, Leist M, Luijten M, Marx-Stoelting P, Poetz O, van Ravenzwaay B, Roggeband R, Rogiers V, Roth A, Sanders P, Thomas RS, Marie Vinggaard A, Vinken M, van de Water B, Luch A, Tralau T. Schmeisser S, et al. Among authors: vinken m. Environ Int. 2023 Aug;178:108082. doi: 10.1016/j.envint.2023.108082. Epub 2023 Jul 4. Environ Int. 2023. PMID: 37422975 Free article. Review.
At the same time, the scientific toolbox used for risk assessment is continuously enriched by the development of "New Approach Methodologies" (NAMs). While this term does not define the age or the state of readiness of the innovation, it covers a wide range of methods, inc …
At the same time, the scientific toolbox used for risk assessment is continuously enriched by the development of "New Approach Methodologies …
Hepatology in space: Effects of spaceflight and simulated microgravity on the liver.
Vinken M. Vinken M. Liver Int. 2022 Dec;42(12):2599-2606. doi: 10.1111/liv.15444. Epub 2022 Oct 12. Liver Int. 2022. PMID: 36183343 Review.
Although most of these observations remain to be fully validated in humans, appropriate measures to counteract liver pathogenesis should be considered, especially in view of long-term space missions....
Although most of these observations remain to be fully validated in humans, appropriate measures to counteract liver pathogenesis should be …
Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis.
Romualdo GR, Silva EDA, Da Silva TC, Aloia TPA, Nogueira MS, De Castro IA, Vinken M, Barbisan LF, Cogliati B. Romualdo GR, et al. Among authors: vinken m. Environ Toxicol. 2020 Apr;35(4):518-527. doi: 10.1002/tox.22887. Epub 2019 Dec 5. Environ Toxicol. 2020. PMID: 31804025
Furthermore, burdock intervention diminished the size of GST-P(+) remodeling preneoplastic lesions (PNLs) and displayed a trend on reducing hepatocyte proliferation (Ki-67) inside them. These findings suggest that short-term exposure to BRE alleviated remodeling PNL develo …
Furthermore, burdock intervention diminished the size of GST-P(+) remodeling preneoplastic lesions (PNLs) and displayed a trend on reducing …
Primary hepatocytes and their cultures for the testing of drug-induced liver injury.
Vilas-Boas V, Cooreman A, Gijbels E, Van Campenhout R, Gustafson E, Ballet S, Annaert P, Cogliati B, Vinken M. Vilas-Boas V, et al. Among authors: vinken m. Adv Pharmacol. 2019;85:1-30. doi: 10.1016/bs.apha.2018.08.001. Epub 2018 Sep 1. Adv Pharmacol. 2019. PMID: 31307583 Review.
The present paper gives an overview of traditional and more recently introduced strategies to counteract this dedifferentiation process in an attempt to set up culture models that can be used for long-term testing purposes. The relevance and applicability of such optimized …
The present paper gives an overview of traditional and more recently introduced strategies to counteract this dedifferentiation process in a …
Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory.
Walrave L, Vinken M, Albertini G, De Bundel D, Leybaert L, Smolders IJ. Walrave L, et al. Among authors: vinken m. Front Cell Neurosci. 2016 Dec 20;10:288. doi: 10.3389/fncel.2016.00288. eCollection 2016. Front Cell Neurosci. 2016. PMID: 28066184 Free PMC article.
Cx43 blockade did however significantly impair the spatial short-term memory in a delayed spontaneous alternation Y maze task. These results indicate that Cx43 HCs play a role in spatial short-term memory....
Cx43 blockade did however significantly impair the spatial short-term memory in a delayed spontaneous alternation Y maze task. These …
Adverse outcome pathway development from protein alkylation to liver fibrosis.
Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M. Horvat T, et al. Among authors: vinken m. Arch Toxicol. 2017 Apr;91(4):1523-1543. doi: 10.1007/s00204-016-1814-8. Epub 2016 Aug 19. Arch Toxicol. 2017. PMID: 27542122 Free PMC article. Review.
Here, we present the developed AOP for liver fibrosis and demonstrate a linkage between hepatic injury caused by chemical protein alkylation and the formation of liver fibrosis, supported by coherent and consistent scientific data. This long-term process, in which inflamma …
Here, we present the developed AOP for liver fibrosis and demonstrate a linkage between hepatic injury caused by chemical protein alkylation …
Toxicogenomics directory of chemically exposed human hepatocytes.
Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG. Grinberg M, et al. Among authors: vinken m. Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16. Arch Toxicol. 2014. PMID: 25399406
A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. ...
A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. ...
Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.
Ramboer E, Vanhaecke T, Rogiers V, Vinken M. Ramboer E, et al. Among authors: vinken m. Drug Metab Rev. 2013 May;45(2):196-217. doi: 10.3109/03602532.2012.756010. Epub 2013 Feb 1. Drug Metab Rev. 2013. PMID: 23368091 Review.
In the first part of the article, an updated overview of hepatic drug transporters is provided, followed by a state-of-the-art review of drug-transporter production and activity in primary hepatocyte cultures (PHCs), being the gold-standard in vitro system. Specific focus is here …
In the first part of the article, an updated overview of hepatic drug transporters is provided, followed by a state-of-the-art review of dru …
Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies.
Fraczek J, Bolleyn J, Vanhaecke T, Rogiers V, Vinken M. Fraczek J, et al. Among authors: vinken m. Arch Toxicol. 2013 Apr;87(4):577-610. doi: 10.1007/s00204-012-0983-3. Epub 2012 Dec 15. Arch Toxicol. 2013. PMID: 23242478 Review.
Cultures of primary hepatocytes became already an inherent part of the preclinical pharmaco-toxicological testing battery, yet their routine use, particularly for long-term assays, is limited by the progressive deterioration of liver-specific features. ...
Cultures of primary hepatocytes became already an inherent part of the preclinical pharmaco-toxicological testing battery, yet their routine …
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