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New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways.
He J, Wang H, Vijg J. He J, et al. Among authors: vijg j. Chem Biodivers. 2019 Sep;16(9):e1900176. doi: 10.1002/cbdv.201900176. Epub 2019 Sep 17. Chem Biodivers. 2019. PMID: 31368177 Review.
Type 2 diabetes is a serious metabolic disease as a long-term threat to human health. Insulin resistance is not only the basis and major feature of type 2 diabetes, but also the main etiology of diseases such as hypertension, hyperlipidemia and coronary heart disease. ...
Type 2 diabetes is a serious metabolic disease as a long-term threat to human health. Insulin resistance is not only the basis and ma …
Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain.
Andriani GA, Vijg J, Montagna C. Andriani GA, et al. Among authors: vijg j. Mech Ageing Dev. 2017 Jan;161(Pt A):19-36. doi: 10.1016/j.mad.2016.03.007. Epub 2016 Mar 21. Mech Ageing Dev. 2017. PMID: 27013377 Free PMC article. Review.
Aneuploidy is commonly linked to pathological states. It is a hallmark of spontaneous abortions and birth defects and it is observed virtually in every human tumor, therefore being generally regarded as detrimental for the development or the maturation of tissues under phy …
Aneuploidy is commonly linked to pathological states. It is a hallmark of spontaneous abortions and birth defects and it is observed …
Genome instability, cancer and aging.
Maslov AY, Vijg J. Maslov AY, et al. Among authors: vijg j. Biochim Biophys Acta. 2009 Oct;1790(10):963-9. doi: 10.1016/j.bbagen.2009.03.020. Epub 2009 Mar 31. Biochim Biophys Acta. 2009. PMID: 19344750 Free PMC article. Review.
This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. ...
This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage …
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice.
Busuttil RA, Rubio M, Dollé ME, Campisi J, Vijg J. Busuttil RA, et al. Among authors: vijg j. DNA Repair (Amst). 2006 Jan 5;5(1):52-60. doi: 10.1016/j.dnarep.2005.07.006. Epub 2005 Aug 26. DNA Repair (Amst). 2006. PMID: 16126462
The results indicated the emergence of jackpot mutations of rapidly changing frequency, most likely reflecting the successive emergence and decline of dominant cell clones during long-term culture. These findings show that the lacZ-plasmid locus is a valid reporter for stu …
The results indicated the emergence of jackpot mutations of rapidly changing frequency, most likely reflecting the successive emergence and …
Transgenic assays for mutations and cancer: current status and future perspectives.
Vijg J, van Steeg H. Vijg J, et al. Mutat Res. 1998 May 25;400(1-2):337-54. doi: 10.1016/s0027-5107(98)00030-x. Mutat Res. 1998. PMID: 9685694 Review.
Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. ...
Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bio …
[Extension of life: the apotheosis of the molecular biomedical sciences?].
Vijg J. Vijg J. Tijdschr Gerontol Geriatr. 1990 Oct;21(5):199-204. Tijdschr Gerontol Geriatr. 1990. PMID: 2251720 Dutch.
On the basis of these developments more insight will be obtained in the causes of ageing and it will be possible to design new therapies for many of the adverse effects associated with ageing. In the long term it may be possible to remove the basic causes of ageing by gene …
On the basis of these developments more insight will be obtained in the causes of ageing and it will be possible to design new therapies for …
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.
Gossen JA, de Leeuw WJ, Tan CH, Zwarthoff EC, Berends F, Lohman PH, Knook DL, Vijg J. Gossen JA, et al. Among authors: vijg j. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7971-5. doi: 10.1073/pnas.86.20.7971. Proc Natl Acad Sci U S A. 1989. PMID: 2530578 Free PMC article.
In addition to its use in fundamental research, the system could be used as a sensitive, organ-specific, short-term mutagenicity assay....
In addition to its use in fundamental research, the system could be used as a sensitive, organ-specific, short-term mutagenicity assa …
The removal of UV-induced pyrimidine dimers from DNA of rat skin cells in vitro and in vivo in relation to aging.
Mullaart E, Roza L, Lohman PH, Vijg J. Mullaart E, et al. Among authors: vijg j. Mech Ageing Dev. 1989 Mar;47(3):253-64. doi: 10.1016/0047-6374(89)90037-7. Mech Ageing Dev. 1989. PMID: 2716371
However, since a considerable fraction of the pyrimidine dimers appeared to be persistent in fibroblasts and keratinocytes, demonstrated by both enzymatic and immunochemical assays, the possibility is discussed that long-term exposure of skin cells to UV may lead to an acc …
However, since a considerable fraction of the pyrimidine dimers appeared to be persistent in fibroblasts and keratinocytes, demonstrated by …