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Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Cil O, et al. Among authors: verkman as. J Am Soc Nephrol. 2016 Dec;27(12):3706-3714. doi: 10.1681/ASN.2015121312. Epub 2016 May 6. J Am Soc Nephrol. 2016. PMID: 27153921 Free PMC article.
However, in mice treated acutely with furosemide, administration of PDS(inh)-C01 produced a 30% increase in urine output, with increased Na(+) and Cl(-) excretion. In mice treated long term with furosemide, in which renal pendrin is upregulated, PDS(inh)-C01 produced a 60% …
However, in mice treated acutely with furosemide, administration of PDS(inh)-C01 produced a 30% increase in urine output, with increased Na( …
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Among authors: verkman as. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.
To mimic the administration of VX-770 alone or in combination with VX-809, we examined its long-term effect in immortalized and primary human respiratory epithelia. ...
To mimic the administration of VX-770 alone or in combination with VX-809, we examined its long-term effect in immortalized and prima …
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.
Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Skucas VA, et al. Among authors: verkman as. J Neurosci. 2011 Apr 27;31(17):6392-7. doi: 10.1523/JNEUROSCI.6249-10.2011. J Neurosci. 2011. PMID: 21525279 Free PMC article.
Little is known about the potential for AQP4 to influence synaptic plasticity, although many studies have shown that it regulates the response of the CNS to injury. Therefore, we evaluated long-term potentiation (LTP) and long-term depression (LTD) in AQP4 knock-out …
Little is known about the potential for AQP4 to influence synaptic plasticity, although many studies have shown that it regulates the respon …
Expression and localization of aquaporin 1 and 3 in human fetal membranes.
Mann SE, Ricke EA, Yang BA, Verkman AS, Taylor RN. Mann SE, et al. Among authors: verkman as. Am J Obstet Gynecol. 2002 Oct;187(4):902-7. doi: 10.1067/mob.2002.127168. Am J Obstet Gynecol. 2002. PMID: 12388974
STUDY DESIGN: Placentas were collected from women with intact membranes not in labor who underwent elective cesarean sections at term (37-40 weeks). The membranes (amnion and chorion) directly overlying the placenta were sampled as well as the free-floating reflected membr …
STUDY DESIGN: Placentas were collected from women with intact membranes not in labor who underwent elective cesarean sections at term …
Serial permeability barriers to water transport in human placental vesicles.
Illsley NP, Verkman AS. Illsley NP, et al. Among authors: verkman as. J Membr Biol. 1986;94(3):267-78. doi: 10.1007/BF01869722. J Membr Biol. 1986. PMID: 2435911
Microvillous vesicles were prepared from term human placenta by shearing, differential centrifugation and Mg2+ precipitation. ...
Microvillous vesicles were prepared from term human placenta by shearing, differential centrifugation and Mg2+ precipitation. ...