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Off-the-Shelf Synthetic Biodegradable Grafts Transform In Situ into a Living Arteriovenous Fistula in a Large Animal Model.
Besseling PJ, Szymczyk W, Teraa M, Toorop RJ, Wu DJ, Driessen RCH, Lichauco AM, Janssen HM, van de Kaa M, den Ouden K, de Bree PM, Fledderus JO, Bouten CVC, de Borst GJ, Dankers PYW, Verhaar MC. Besseling PJ, et al. Among authors: verhaar mc. Adv Healthc Mater. 2024 Mar 7:e2303888. doi: 10.1002/adhm.202303888. Online ahead of print. Adv Healthc Mater. 2024. PMID: 38451476
In situ tissue engineering (TE) may overcome these limitations by combining the initial success of synthetic grafts with long-term advantages of autologous vessels by using biodegradable grafts that transform into autologous vascular tissue at the site of implantation. ... …
In situ tissue engineering (TE) may overcome these limitations by combining the initial success of synthetic grafts with long-term ad …
Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation.
Kardol-Hoefnagel T, Senejohnny DM, Kamburova EG, Wisse BW, Reteig L, Gruijters ML, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Melchers RCA, Seelen MAJ, Sanders JS, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens MACJ, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KAMI, van der Weerd NC, Ten Berge IJM, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Roelen DL, Claas FH, Bemelman FJ, Senev A, Naesens M, Heidt S, Otten HG. Kardol-Hoefnagel T, et al. Among authors: verhaar mc. HLA. 2024 Jan;103(1):e15346. doi: 10.1111/tan.15346. HLA. 2024. PMID: 38239046
Fifty-three patients (69.7%) had DESA against one donor epitope (range 1-5). Long-term graft survival rate in patients with clinically relevant DESA was 32%, rendering DESA a superior parameter to classical DSA (60%). ...
Fifty-three patients (69.7%) had DESA against one donor epitope (range 1-5). Long-term graft survival rate in patients with clinicall …
Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease.
Yousef Yengej FA, Pou Casellas C, Ammerlaan CME, Olde Hanhof CJA, Dilmen E, Beumer J, Begthel H, Meeder EMG, Hoenderop JG, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Among authors: verhaar mc. Cell Rep. 2024 Jan 23;43(1):113614. doi: 10.1016/j.celrep.2023.113614. Epub 2023 Dec 29. Cell Rep. 2024. PMID: 38159278 Free article.
Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. ...
Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids gro …
Individual lifetime benefit from low-dose colchicine in patients with chronic coronary artery disease.
Burger PM, Dorresteijn JAN, Fiolet ATL, Koudstaal S, Eikelboom JW, Nidorf SM, Thompson PL, Cornel JH, Budgeon CA, Westendorp ICD, Beelen DPW, Martens FMAC, Steg PG, Asselbergs FW, Cramer MJ, Teraa M, Bhatt DL, Visseren FLJ, Mosterd A; LoDoCo2 Trial Investigators; UCC-SMART Study Group; REACH Registry Investigators. Burger PM, et al. Eur J Prev Cardiol. 2023 Dec 21;30(18):1950-1962. doi: 10.1093/eurjpc/zwad221. Eur J Prev Cardiol. 2023. PMID: 37409348
They may be expected to be of at least similar magnitude to those of intensified LDL-c and SBP reduction in a majority of patients already on conventional lipid-lowering and blood pressure-lowering therapy. The long-term benefits of treatment with low-dose colchicine were …
They may be expected to be of at least similar magnitude to those of intensified LDL-c and SBP reduction in a majority of patients already o …
Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology.
Olde Hanhof CJA, Dilmen E, Yousef Yengej FA, Latta F, Ammerlaan CME, Schreurs J, Hooijmaijers L, Jansen J, Rookmaaker MB, Orhon I, Verhaar MC, Hoenderop JG. Olde Hanhof CJA, et al. Among authors: verhaar mc. Front Cell Dev Biol. 2023 Jan 25;11:1086823. doi: 10.3389/fcell.2023.1086823. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36760360 Free PMC article.
Kidney tubuloids are cell models that are derived from human or mouse renal epithelial cells and show high similarities with their in vivo counterparts. Tubuloids grow polarized in 3D, allow for long-term expansion, and represent multiple segments of the nephron, as shown …
Kidney tubuloids are cell models that are derived from human or mouse renal epithelial cells and show high similarities with their in vivo c …
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids.
Yousef Yengej FA, Jansen J, Ammerlaan CME, Dilmen E, Pou Casellas C, Masereeuw R, Hoenderop JG, Smeets B, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Among authors: verhaar mc. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2216836120. doi: 10.1073/pnas.2216836120. Epub 2023 Feb 1. Proc Natl Acad Sci U S A. 2023. PMID: 36724260 Free PMC article.
Association of Ischemic Imaging Phenotype With Progression of Brain Atrophy and Cerebrovascular Lesions on MRI: The SMART-MR Study.
Rissanen I, Lucci C, Ghaznawi R, Hendrikse J, Kappelle LJ, Geerlings MI; UCC-SMART-Study Group. Rissanen I, et al. Neurology. 2021 Sep 14;97(11):e1063-e1074. doi: 10.1212/WNL.0000000000012539. Epub 2021 Jul 21. Neurology. 2021. PMID: 34290128
BACKGROUND AND OBJECTIVE: To investigate the association of silent vascular lesions, imaging negative ischemia, and symptomatic cerebrovascular disease with long-term progression of brain atrophy and cerebrovascular lesions in patients with arterial disease. ...
BACKGROUND AND OBJECTIVE: To investigate the association of silent vascular lesions, imaging negative ischemia, and symptomatic cerebrovascu …
Long Term Survival and Limb Salvage in Patients With Non-Revascularisable Chronic Limb Threatening Ischaemia.
Verwer MC, Wijnand JGJ, Teraa M, Verhaar MC, de Borst GJ. Verwer MC, et al. Among authors: verhaar mc. Eur J Vasc Endovasc Surg. 2021 Aug;62(2):225-232. doi: 10.1016/j.ejvs.2021.04.003. Epub 2021 Jun 2. Eur J Vasc Endovasc Surg. 2021. PMID: 34090781 Free article.
OBJECTIVE: The aim of this study was to provide long term survival and limb salvage rates for patients with non-revascularisable (NR) chronic limb threatening ischaemia (CLTI). ...
OBJECTIVE: The aim of this study was to provide long term survival and limb salvage rates for patients with non-revascularisable (NR) …
Kidney Organoids and Tubuloids.
Yousef Yengej FA, Jansen J, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Among authors: verhaar mc. Cells. 2020 May 26;9(6):1326. doi: 10.3390/cells9061326. Cells. 2020. PMID: 32466429 Free PMC article. Review.
ASC tubuloids on the other hand recapitulate renewal and repair in the adult kidney tubule and give rise to long-term expandable and genetically stable cultures that consist of adult proximal tubule, loop of Henle, distal tubule, and collecting duct epithelium. ...
ASC tubuloids on the other hand recapitulate renewal and repair in the adult kidney tubule and give rise to long-term expandable and …
The Small RNA Repertoire of Small Extracellular Vesicles Isolated From Donor Kidney Preservation Fluid Provides a Source for Biomarker Discovery for Organ Quality and Posttransplantation Graft Function.
Gremmels H, de Jong OG, Toorop RJ, Michielsen L, van Zuilen AD, Vlassov AV, Verhaar MC, van Balkom BWM. Gremmels H, et al. Among authors: verhaar mc. Transplant Direct. 2019 Aug 12;5(9):e484. doi: 10.1097/TXD.0000000000000929. eCollection 2019 Sep. Transplant Direct. 2019. PMID: 31579812 Free PMC article.
Delayed graft function (DGF) after kidney transplantation is negatively associated with long-term graft function and survival. Kidney function after transplantation depends on multiple factors, both donor- and recipient-associated. ...CONCLUSIONS: Overall, the predictive p …
Delayed graft function (DGF) after kidney transplantation is negatively associated with long-term graft function and survival. Kidney …
34 results