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The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials.
Harinath G, Zalzala S, Nyquist A, Wouters M, Isman A, Moel M, Verdin E, Kaeberlein M, Kennedy B, Bischof E. Harinath G, et al. Among authors: verdin e. Ageing Res Rev. 2024 Apr 3;97:102293. doi: 10.1016/j.arr.2024.102293. Online ahead of print. Ageing Res Rev. 2024. PMID: 38574864 Review.
With geroscience research evolving at a fast pace, the need arises for human randomized controlled trials to assess the efficacy of geroprotective interventions to prevent age-related adverse outcomes, disease, and mortality in normative aging cohorts. However, to confirm efficac …
With geroscience research evolving at a fast pace, the need arises for human randomized controlled trials to assess the efficacy of geroprot …
A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging.
Nomura M, Murad NF, Madhavan SS, Eap B, Garcia TY, Aguirre CG, Verdin E, Ellerby L, Furman D, Newman JC. Nomura M, et al. Among authors: verdin e. bioRxiv [Preprint]. 2023 Dec 4:2023.12.01.569598. doi: 10.1101/2023.12.01.569598. bioRxiv. 2023. PMID: 38106160 Free PMC article. Preprint.
In summary, our findings demonstrate that BHB mitigates the microglial response to inflammatory stimuli, like LPS, possibly leading to decreased chronic inflammation in the brain after long-term KD treatment in aging mice....
In summary, our findings demonstrate that BHB mitigates the microglial response to inflammatory stimuli, like LPS, possibly leading to decre …
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M. Lyons DE, et al. Among authors: verdin e. Viruses. 2023 Oct 28;15(11):2171. doi: 10.3390/v15112171. Viruses. 2023. PMID: 38005849 Free PMC article.
We propose a novel "block-lock-stop" approach, entailing long term durable silencing of viral expression towards an irreversible transcriptionally inactive latent provirus to achieve long term antiretroviral free control of the virus. ...
We propose a novel "block-lock-stop" approach, entailing long term durable silencing of viral expression towards an irreversible tran …
Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice.
Margier M, Kuehnemann C, Hulo N, Morales J, Ashok Kumaar PV, Cros C, Cannelle H, Charmetant J, Verdin E, Canault M, Grozio A. Margier M, et al. Among authors: verdin e. Cells. 2022 Dec 27;12(1):108. doi: 10.3390/cells12010108. Cells. 2022. PMID: 36611902 Free PMC article.
We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardiotoxicity and physical dysfunction in vivo. To assess the short- and long-term toxicity, two Doxo regimens were tested, acute and chronic. ...
We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardiotoxicity and physical dysfunction in vivo …
SARS-CoV-2, COVID-19 and the Ageing Immune System.
Bartleson JM, Radenkovic D, Covarrubias AJ, Furman D, Winer DA, Verdin E. Bartleson JM, et al. Among authors: verdin e. Nat Aging. 2021 Sep;1(9):769-782. doi: 10.1038/s43587-021-00114-7. Epub 2021 Sep 14. Nat Aging. 2021. PMID: 34746804 Free PMC article.
New or adapted therapeutics that target ageing-associated pathways may be important tools to reduce the burden of death and long-term disability caused by this pandemic. Proposed interventions aimed at immunosenescence could enhance immune function not only in the elderly …
New or adapted therapeutics that target ageing-associated pathways may be important tools to reduce the burden of death and long-term …
Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human Cytomegalovirus.
Walter M, Perrone R, Verdin E. Walter M, et al. Among authors: verdin e. J Virol. 2021 Jul 12;95(15):e0080221. doi: 10.1128/JVI.00802-21. Epub 2021 Jul 12. J Virol. 2021. PMID: 34011551 Free PMC article.
As a consequence, and even though engineered viruses do not stably persist in the viral population, remaining viruses have a replication defect, leading to a long-term reduction of viral levels. This marks an important step toward developing effective gene drives in herpes …
As a consequence, and even though engineered viruses do not stably persist in the viral population, remaining viruses have a replication def …
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Meyer JG, et al. Among authors: verdin e. PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018. PLoS One. 2018. PMID: 30586434 Free PMC article.
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high-fat diet (HFD), with or without glucose or fructose supplementation, and quantified liver metabolites, 861 proteins, and 1,815 protein level …
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high- …
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells.
Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, Lichterfeld M. Kuo HH, et al. Among authors: verdin e. Immunity. 2018 Jun 19;48(6):1183-1194.e5. doi: 10.1016/j.immuni.2018.04.004. Epub 2018 May 22. Immunity. 2018. PMID: 29802019 Free PMC article.
HIV-1 infection of CD4(+) T cells leads to cytopathic effects and cell demise, which is counter to the observation that certain HIV-1-infected cells possess a remarkable long-term stability and can persist lifelong in infected individuals treated with suppressive antiretro …
HIV-1 infection of CD4(+) T cells leads to cytopathic effects and cell demise, which is counter to the observation that certain HIV-1-infect …
Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.
Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Tomiyama AJ, et al. Among authors: verdin e. Nutr Healthy Aging. 2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017. Nutr Healthy Aging. 2017. PMID: 28447069 Free PMC article.
OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans. METHODS: We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell tel …
OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans. METHODS: We tested whether long-term …
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.
Trono D, Van Lint C, Rouzioux C, Verdin E, Barré-Sinoussi F, Chun TW, Chomont N. Trono D, et al. Among authors: verdin e. Science. 2010 Jul 9;329(5988):174-80. doi: 10.1126/science.1191047. Science. 2010. PMID: 20616270 Review.
This review discusses our current understanding of HIV persistence and the limitations of potential approaches to eradicate the virus and accordingly pleads for a joint multidisciplinary effort toward two highly related goals: the development of an HIV prophylactic vaccine and th …
This review discusses our current understanding of HIV persistence and the limitations of potential approaches to eradicate the virus and ac …