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Modifiable risk factors and risk of myocardial infarction in offspring with parental disease.
Møller AL, Larson M, Xanthakis V, Vasan RS, Andersson C. Møller AL, et al. Among authors: vasan rs. Eur J Prev Cardiol. 2024 May 9:zwae169. doi: 10.1093/eurjpc/zwae169. Online ahead of print. Eur J Prev Cardiol. 2024. PMID: 38722824
AIMS: Children of patients with early-onset myocardial infarction (MI) are at increased risk, but the importance of concordant versus discordant parent-offspring risk factor profiles on MI risk is largely unknown. We quantified the long-term absolute risk of MI according t …
AIMS: Children of patients with early-onset myocardial infarction (MI) are at increased risk, but the importance of concordant versus discor …
Association of Arterial Stiffness With Mid- to Long-Term Home Blood Pressure Variability in the Electronic Framingham Heart Study: Cohort Study.
Wang X, Zhang Y, Pathiravasan CH, Ukonu NC, Rong J, Benjamin EJ, McManus DD, Larson MG, Vasan RS, Hamburg NM, Murabito JM, Liu C, Mitchell GF. Wang X, et al. Among authors: vasan rs. JMIR Cardio. 2024 Apr 8;8:e54801. doi: 10.2196/54801. JMIR Cardio. 2024. PMID: 38587880 Free PMC article.
BACKGROUND: Short-term blood pressure variability (BPV) is associated with arterial stiffness in patients with hypertension. Few studies have examined associations between arterial stiffness and digital home BPV over a mid- to long-term time span, irrespective of un …
BACKGROUND: Short-term blood pressure variability (BPV) is associated with arterial stiffness in patients with hypertension. Few stud …
Adjustment for Renal Function Improves the Prognostic Performance of Urinary Thromboxane Metabolites.
Barton BA, Kronsberg SS, Hariri E, Vasan RS, Rade GA, Xanthakis V, Kickler TS, Rade JJ. Barton BA, et al. Among authors: vasan rs. Clin Chem. 2024 Apr 3;70(4):660-668. doi: 10.1093/clinchem/hvae015. Clin Chem. 2024. PMID: 38416712
CONCLUSION: Adjustment for eGFR strengthens the association of urinary TXB2-M with long-term mortality risk irrespective of aspirin use....
CONCLUSION: Adjustment for eGFR strengthens the association of urinary TXB2-M with long-term mortality risk irrespective of aspirin u …
Prevalence of Aortic Valve Calcium and the Long-Term Risk of Incident Severe Aortic Stenosis.
Whelton SP, Jha K, Dardari Z, Razavi AC, Boakye E, Dzaye O, Verghese D, Shah S, Budoff MJ, Matsushita K, Carr JJ, Vasan RS, Blumenthal RS, Anchouche K, Thanassoulis G, Guo X, Rotter JI, McClelland RL, Post WS, Blaha MJ. Whelton SP, et al. Among authors: vasan rs. JACC Cardiovasc Imaging. 2024 Jan;17(1):31-42. doi: 10.1016/j.jcmg.2023.02.018. Epub 2023 May 10. JACC Cardiovasc Imaging. 2024. PMID: 37178073
The adjudication of severe AS was performed via chart review of all hospital visits and supplemented with visit 6 echocardiographic data. The association between AVC and long-term incident severe AS was evaluated using multivariable Cox HRs. ...The risk of severe AS was ex …
The adjudication of severe AS was performed via chart review of all hospital visits and supplemented with visit 6 echocardiographic data. Th …
Correlations between complex human phenotypes vary by genetic background, gender, and environment.
Elgart M, Goodman MO, Isasi C, Chen H, Morrison AC, de Vries PS, Xu H, Manichaikul AW, Guo X, Franceschini N, Psaty BM, Rich SS, Rotter JI, Lloyd-Jones DM, Fornage M, Correa A, Heard-Costa NL, Vasan RS, Hernandez R, Kaplan RC, Redline S; Trans-Omics for Precision Medicine (TOPMed) Consortium; Sofer T. Elgart M, et al. Among authors: vasan rs. Cell Rep Med. 2022 Dec 20;3(12):100844. doi: 10.1016/j.xcrm.2022.100844. Epub 2022 Dec 12. Cell Rep Med. 2022. PMID: 36513073 Free PMC article.
We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet 20 faster. We estimate genetic and environmental correlations between over 7,000 phenotype …
We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which w …
Dietary metabolic signatures and cardiometabolic risk.
Shah RV, Steffen LM, Nayor M, Reis JP, Jacobs DR, Allen NB, Lloyd-Jones D, Meyer K, Cole J, Piaggi P, Vasan RS, Clish CB, Murthy VL. Shah RV, et al. Among authors: vasan rs. Eur Heart J. 2023 Feb 14;44(7):557-569. doi: 10.1093/eurheartj/ehac446. Eur Heart J. 2023. PMID: 36424694 Free PMC article.
Here, machine learning approaches were used to identify individual metabolic patterns related to diet and relation to long-term CM-CVD in early adulthood. METHODS AND RESULTS: In 2259 White and Black adults (age 32.1 3.6 years, 45% women, 44% Black) in the Coronary Artery …
Here, machine learning approaches were used to identify individual metabolic patterns related to diet and relation to long-term CM-CV …
Blood-Based Fingerprint of Cardiorespiratory Fitness and Long-Term Health Outcomes in Young Adulthood.
Shah RV, Miller P, Colangelo LA, Chernofsky A, Houstis NE, Malhotra R, Velagaleti RS, Jacobs DR Jr, Gabriel KP, Reis JP, Lloyd-Jones DM, Clish CB, Larson MG, Vasan RS, Murthy VL, Lewis GD, Nayor M. Shah RV, et al. Among authors: vasan rs. J Am Heart Assoc. 2022 Sep 20;11(18):e026670. doi: 10.1161/JAHA.122.026670. Epub 2022 Sep 8. J Am Heart Assoc. 2022. PMID: 36073631 Free PMC article.
A metabolomic fitness score was derived/validated in the FHS and was associated with long-term outcomes in the younger CARDIA (Coronary Artery Risk Development in Young Adults) study. ...Conclusions A blood-based biomarker of cardiorespiratory fitness largely independent o …
A metabolomic fitness score was derived/validated in the FHS and was associated with long-term outcomes in the younger CARDIA (Corona …
Red Blood Cell DHA Is Inversely Associated with Risk of Incident Alzheimer's Disease and All-Cause Dementia: Framingham Offspring Study.
Sala-Vila A, Satizabal CL, Tintle N, Melo van Lent D, Vasan RS, Beiser AS, Seshadri S, Harris WS. Sala-Vila A, et al. Among authors: vasan rs. Nutrients. 2022 Jun 9;14(12):2408. doi: 10.3390/nu14122408. Nutrients. 2022. PMID: 35745137 Free PMC article.
Red blood cell (RBC) status of DHA is an objective measure of long-term dietary DHA intake. In this prospective observational study conducted within the Framingham Offspring Cohort (1490 dementia-free participants aged 65 years old), we examined the association of RBC DHA …
Red blood cell (RBC) status of DHA is an objective measure of long-term dietary DHA intake. In this prospective observational study c …
Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index.
Schuchardt JP, Cerrato M, Ceseri M, DeFina LF, Delgado GE, Gellert S, Hahn A, Howard BV, Kadota A, Kleber ME, Latini R, Maerz W, Manson JE, Mora S, Park Y, Sala-Vila A, von Schacky C, Sekikawa A, Tintle N, Tucker KL, Vasan RS, Harris WS. Schuchardt JP, et al. Among authors: vasan rs. Prostaglandins Leukot Essent Fatty Acids. 2022 Apr;179:102418. doi: 10.1016/j.plefa.2022.102418. Epub 2022 Mar 24. Prostaglandins Leukot Essent Fatty Acids. 2022. PMID: 35366625 Free PMC article.
Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. ...
Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different …
Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
Oelsner EC, Krishnaswamy A, Balte PP, Allen NB, Ali T, Anugu P, Andrews HF, Arora K, Asaro A, Barr RG, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Coady S, Cole SA, Coresh J, Cornell E, Correa A, Couper D, Cushman M, Demmer RT, Elkind MSV, Folsom AR, Fretts AM, Gabriel KP, Gallo LC, Gutierrez J, Han MLK, Henderson JM, Howard VJ, Isasi CR, Jacobs DR Jr, Judd SE, Mukaz DK, Kanaya AM, Kandula NR, Kaplan RC, Kinney GL, Kucharska-Newton A, Lee JS, Lewis CE, Levine DA, Levitan EB, Levy BD, Make BJ, Malloy K, Manly JJ, Mendoza-Puccini C, Meyer KA, Min YN, Moll MR, Moore WC, Mauger D, Ortega VE, Palta P, Parker MM, Phipatanakul W, Post WS, Postow L, Psaty BM, Regan EA, Ring K, Roger VL, Rotter JI, Rundek T, Sacco RL, Schembri M, Schwartz DA, Seshadri S, Shikany JM, Sims M, Hinckley Stukovsky KD, Talavera GA, Tracy RP, Umans JG, Vasan RS, Watson KE, Wenzel SE, Winters K, Woodruff PG, Xanthakis V, Zhang Y, Zhang Y; C4R Investigators. Oelsner EC, et al. Among authors: vasan rs. Am J Epidemiol. 2022 Jun 27;191(7):1153-1173. doi: 10.1093/aje/kwac032. Am J Epidemiol. 2022. PMID: 35279711 Free PMC article.
This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term health trajectories....
This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and ass …
92 results