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Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.
Vaill M, Kawanishi K, Varki N, Gagneux P, Varki A. Vaill M, et al. Among authors: varki a. Physiol Rev. 2023 Jul 1;103(3):2171-2229. doi: 10.1152/physrev.00040.2021. Epub 2023 Jan 5. Physiol Rev. 2023. PMID: 36603157 Review.
Anthropogeny is a classic term encompassing transdisciplinary investigations of the origins of the human species. ...
Anthropogeny is a classic term encompassing transdisciplinary investigations of the origins of the human species. ...
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Zaramela LS, Martino C, Alisson-Silva F, Rees SD, Diaz SL, Chuzel L, Ganatra MB, Taron CH, Secrest P, Zuñiga C, Huang J, Siegel D, Chang G, Varki A, Zengler K. Zaramela LS, et al. Among authors: varki a. Nat Microbiol. 2019 Dec;4(12):2082-2089. doi: 10.1038/s41564-019-0564-9. Epub 2019 Sep 23. Nat Microbiol. 2019. PMID: 31548686 Free PMC article.
In Western diets, red meat is a frequently eaten food(2), but long-term consumption has been associated with increased risk of disease(3,4). ...
In Western diets, red meat is a frequently eaten food(2), but long-term consumption has been associated with increased risk of diseas …
Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.
Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A. Naito-Matsui Y, et al. Among authors: varki a. J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3. J Biol Chem. 2017. PMID: 28049733 Free PMC article.
However, physiological exploration of the reasons for this long term evolutionary selection has been lacking. To explore the consequences of forced expression of Neu5Gc in the brain, we have established brain-specific Cmah transgenic mice. ...
However, physiological exploration of the reasons for this long term evolutionary selection has been lacking. To explore the conseque …
Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence.
Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Feng KH, et al. Among authors: varki a. J Virol. 2015 Jul;89(13):6860-73. doi: 10.1128/JVI.00521-15. Epub 2015 Apr 22. J Virol. 2015. PMID: 25903329 Free PMC article.
The rescued viruses, including HA and neuraminidase (NA) double reassortants, exhibited similar degrees of long-term growth in MDCK cells. Different host cells showed various levels of susceptibility to infection, but no differences in infectivity were seen when comparing …
The rescued viruses, including HA and neuraminidase (NA) double reassortants, exhibited similar degrees of long-term growth in MDCK c …
A red meat-derived glycan promotes inflammation and cancer progression.
Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A. Samraj AN, et al. Among authors: varki a. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7. doi: 10.1073/pnas.1417508112. Epub 2014 Dec 29. Proc Natl Acad Sci U S A. 2015. PMID: 25548184 Free PMC article.
A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of "red meat" of mammalian origin. Although multiple theories have attempted to explain this human-specific association, none have been conclusively proven. ...
A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of "red meat" of mammalian …
Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts.
Scobie L, Padler-Karavani V, Le Bas-Bernardet S, Crossan C, Blaha J, Matouskova M, Hector RD, Cozzi E, Vanhove B, Charreau B, Blancho G, Bourdais L, Tallacchini M, Ribes JM, Yu H, Chen X, Kracikova J, Broz L, Hejnar J, Vesely P, Takeuchi Y, Varki A, Soulillou JP. Scobie L, et al. Among authors: varki a. J Immunol. 2013 Sep 15;191(6):2907-15. doi: 10.4049/jimmunol.1301195. Epub 2013 Aug 14. J Immunol. 2013. PMID: 23945141 Free PMC article.
However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings …
However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long- …
Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.
Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. Soto PC, et al. Among authors: varki a. J Immunol. 2010 Apr 15;184(8):4185-95. doi: 10.4049/jimmunol.0903420. Epub 2010 Mar 15. J Immunol. 2010. PMID: 20231688 Free PMC article.
In general, humans infected with various viruses, such as HIV and hepatitis C virus, appear to develop stronger reactions and long-term complications. Humans also appear to suffer more from other diseases associated with over-reactivity of the adaptive immune system, such …
In general, humans infected with various viruses, such as HIV and hepatitis C virus, appear to develop stronger reactions and long-term …
Trousseau's syndrome: multiple definitions and multiple mechanisms.
Varki A. Varki A. Blood. 2007 Sep 15;110(6):1723-9. doi: 10.1182/blood-2006-10-053736. Epub 2007 May 11. Blood. 2007. PMID: 17496204 Free PMC article. Review.
In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopat …
In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An an …
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.
Hedlund M, Tangvoranuntakul P, Takematsu H, Long JM, Housley GD, Kozutsumi Y, Suzuki A, Wynshaw-Boris A, Ryan AF, Gallo RL, Varki N, Varki A. Hedlund M, et al. Among authors: varki a. Mol Cell Biol. 2007 Jun;27(12):4340-6. doi: 10.1128/MCB.00379-07. Epub 2007 Apr 9. Mol Cell Biol. 2007. PMID: 17420276 Free PMC article.
Loss of Neu5Gc in hominid ancestors approximately 2 to 3 million years ago likely had immediate and long-term consequences for human biology....
Loss of Neu5Gc in hominid ancestors approximately 2 to 3 million years ago likely had immediate and long-term consequences for human …
P-selectin, carcinoma metastasis and heparin: novel mechanistic connections with therapeutic implications.
Varki A, Varki NM. Varki A, et al. Braz J Med Biol Res. 2001 Jun;34(6):711-7. doi: 10.1590/s0100-879x2001000600003. Braz J Med Biol Res. 2001. PMID: 11378658 Free article. Review.
Several weeks later, all animals showed a decrease in the extent of established metastasis, indicating a long-lasting effect of the short-term intervention. The absence of obvious synergism amongst the three treatments suggests that they all act via a common pathway. ...
Several weeks later, all animals showed a decrease in the extent of established metastasis, indicating a long-lasting effect of the short- …
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