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GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.
Karhu ST, Kinnunen SM, Tölli M, Välimäki MJ, Szabó Z, Talman V, Ruskoaho H. Karhu ST, et al. Among authors: valimaki mj. Arch Toxicol. 2020 Jun;94(6):2113-2130. doi: 10.1007/s00204-020-02711-8. Epub 2020 Mar 17. Arch Toxicol. 2020. PMID: 32185414 Free PMC article.
The exact mechanisms of doxorubicin toxicity are still unclear, partly because most in vitro studies have evaluated the effects of short-term high-dose doxorubicin treatments. Here, we developed an in vitro model of long-term low-dose administration of doxorubicin u …
The exact mechanisms of doxorubicin toxicity are still unclear, partly because most in vitro studies have evaluated the effects of short- …
BRAF V600E mutation does not predict recurrence after long-term follow-up in TNM stage I or II papillary thyroid carcinoma patients.
Pelttari H, Schalin-Jäntti C, Arola J, Löyttyniemi E, Knuutila S, Välimäki MJ. Pelttari H, et al. Among authors: valimaki mj. APMIS. 2012 May;120(5):380-6. doi: 10.1111/j.1600-0463.2011.02844.x. Epub 2011 Nov 25. APMIS. 2012. PMID: 22515292
Our aim was to study if TNM stage I or II PTC patients, with and without recurrence after long-term follow-up would differ in BRAF status. BRAF status was retrospectively determined in tumour tissue from a cohort of low-risk PTC patients (n = 461) with and without recurren …
Our aim was to study if TNM stage I or II PTC patients, with and without recurrence after long-term follow-up would differ in BRAF st …
Health-related quality of life in long-term follow-up of patients with cured TNM Stage I or II differentiated thyroid carcinoma.
Pelttari H, Sintonen H, Schalin-Jäntti C, Välimäki MJ. Pelttari H, et al. Among authors: valimaki mj. Clin Endocrinol (Oxf). 2009 Mar;70(3):493-7. doi: 10.1111/j.1365-2265.2008.03366.x. Epub 2008 Aug 4. Clin Endocrinol (Oxf). 2009. PMID: 18681857
OBJECTIVE: The purpose of this study was to assess the impact of cured low-risk differentiated thyroid carcinoma (DTC) on health-related quality of life (HRQoL) after long-term follow-up. DESIGN: A cross-sectional study including an age- and gender-standardized sample of t …
OBJECTIVE: The purpose of this study was to assess the impact of cured low-risk differentiated thyroid carcinoma (DTC) on health-related qua …
Efficacy and safety of orbital decompression in treatment of thyroid-associated ophthalmopathy: long-term follow-up of 78 patients.
Jernfors M, Välimäki MJ, Setälä K, Malmberg H, Laitinen K, Pitkäranta A. Jernfors M, et al. Among authors: valimaki mj. Clin Endocrinol (Oxf). 2007 Jul;67(1):101-7. doi: 10.1111/j.1365-2265.2007.02845.x. Epub 2007 Apr 27. Clin Endocrinol (Oxf). 2007. PMID: 17466006
OBJECTIVE: To study the long-term results of decompression surgery in patients with thyroid-associated ophthalmopathy (TAO). ...
OBJECTIVE: To study the long-term results of decompression surgery in patients with thyroid-associated ophthalmopathy (TAO). ...
Serum osteoprotegerin and receptor activator of nuclear factor-kappaB ligand (RANKL) concentrations in allogeneic stem cell transplant-recipients: a role in bone loss?
Kananen K, Volin L, Laitinen K, Ruutu T, Välimäki MJ. Kananen K, et al. Among authors: valimaki mj. Osteoporos Int. 2006;17(5):724-30. doi: 10.1007/s00198-005-0040-7. Epub 2005 Dec 31. Osteoporos Int. 2006. PMID: 16437190 Clinical Trial.
PURPOSE: Osteoporosis is a long-term complication of allogeneic stem cell transplantation (SCT). ...
PURPOSE: Osteoporosis is a long-term complication of allogeneic stem cell transplantation (SCT). ...
One-year follow-up of patients with acromegaly treated with fixed or titrated doses of lanreotide Autogel.
Caron P, Bex M, Cullen DR, Feldt-Rasmussen U, Pico Alfonso AM, Pynka S, Racz K, Schopohl J, Tabarin A, Valimaki MJ; Group for Lanreotide Autogel Long-Term Study on Acromegaly. Caron P, et al. Among authors: valimaki mj. Clin Endocrinol (Oxf). 2004 Jun;60(6):734-40. doi: 10.1111/j.1365-2265.2004.02045.x. Clin Endocrinol (Oxf). 2004. PMID: 15163338
CONCLUSION: Dose titration of lanreotide Autogel improved GH and IGF-I control in patients with acromegaly beyond that achieved using fixed doses of lanreotide Autogel or lanreotide microparticles. Titrated long-term lanreotide Autogel treatment is well tolerated....
CONCLUSION: Dose titration of lanreotide Autogel improved GH and IGF-I control in patients with acromegaly beyond that achieved using fixed …
Recovery of bone mass and normalization of bone turnover in long-term survivors of allogeneic bone marrow transplantation.
Kananen K, Volin L, Tähtelä R, Laitinen K, Ruutu T, Välimäki MJ. Kananen K, et al. Among authors: valimaki mj. Bone Marrow Transplant. 2002 Jan;29(1):33-9. doi: 10.1038/sj.bmt.1703317. Bone Marrow Transplant. 2002. PMID: 11840142
BMT patients do not need lifelong immunosuppressive treatment, which should offer favorable circumstances for the recovery of BMD. Thus, 27 (14 women, 13 men) of 29 long-term survivors of our previous study were invited to a follow-up study at a median of 75 months after B …
BMT patients do not need lifelong immunosuppressive treatment, which should offer favorable circumstances for the recovery of BMD. Thus, 27 …
Bone mass and markers of bone and calcium metabolism in postmenopausal women treated with 1,25-dihydroxyvitamin D (Calcitriol) for four years.
Sairanen S, Kärkkäinen M, Tähtelä R, Laitinen K, Mäkelä P, Lamberg-Allardt C, Välimäki MJ. Sairanen S, et al. Among authors: valimaki mj. Calcif Tissue Int. 2000 Aug;67(2):122-7. doi: 10.1007/s00223001118. Calcif Tissue Int. 2000. PMID: 10920216 Clinical Trial.
To evaluate the long-term effect of calcitriol treatment on bone mineral density (BMD) of the femoral neck and lumbar spine and the parameters of calcium and bone metabolism in elderly women, 55 healthy, postmenopausal women, all aged 66 years, were enrolled in the study. …
To evaluate the long-term effect of calcitriol treatment on bone mineral density (BMD) of the femoral neck and lumbar spine and the p …
Effects of short-term treatment with clodronate on parameters of bone metabolism and their diurnal variation.
Sairanen S, Tähtelä R, Laitinen K, Löyttyniemi E, Välimäki MJ. Sairanen S, et al. Among authors: valimaki mj. Calcif Tissue Int. 1997 Feb;60(2):160-3. doi: 10.1007/s002239900207. Calcif Tissue Int. 1997. PMID: 9056164
The goal of the present study was to answer the question whether the diurnal variation of markers of bone turnover is abolished by inhibition of osteoclasts by bisphosphonates and to assess the effects of short-term treatment with clodronate on parameters of calcium and bo …
The goal of the present study was to answer the question whether the diurnal variation of markers of bone turnover is abolished by inhibitio …