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Paediatric heart transplantation: life-saving but not yet a cure.
Boucek R, Chinnock R, Scheel J, Deshpande SR, Urschel S, Kirklin J. Boucek R, et al. Among authors: urschel s. Cardiol Young. 2024 Feb;34(2):233-237. doi: 10.1017/S1047951123004146. Epub 2024 Jan 23. Cardiol Young. 2024. PMID: 38258454
Infants who have required heart transplantation benefit from immunologic "advantages," including long-term survival free from cardiac allograft vasculopathy. Currently 90% of children undergoing a heart transplant are reaching their first-year anniversary and the clinical …
Infants who have required heart transplantation benefit from immunologic "advantages," including long-term survival free from cardiac …
Prospective examination of HLA sensitization after VAD implantation in children and adults.
Townsend M, Pidborochynski T, Cantor RS, Khoury M, Campbell P, Halpin A, Urschel S, Kim D, Nahirniak S, West LJ, Buchholz H, Conway J. Townsend M, et al. Among authors: urschel s. Transpl Immunol. 2023 Oct;80:101892. doi: 10.1016/j.trim.2023.101892. Epub 2023 Jul 5. Transpl Immunol. 2023. PMID: 37419373
Further studies are needed to predict regression or persistence of HLA-Ab developed post-VAD, to understand modulation of individuals' immune responses to sensitizing events, and to determine whether transiently detected HLA-Ab post-VAD recur and have long-term clinical im …
Further studies are needed to predict regression or persistence of HLA-Ab developed post-VAD, to understand modulation of individuals' immun …
Patient and care provider inclusion in the development of an educational graphic novel for heart transplanted teenagers.
Dalmer S, Caulfield S, Murdoch F, Urschel S. Dalmer S, et al. Among authors: urschel s. Pediatr Transplant. 2022 Dec;26(8):e14396. doi: 10.1111/petr.14396. Epub 2022 Sep 20. Pediatr Transplant. 2022. PMID: 36124747
This project aimed to creatively bridge this gap-including teenage patients, their parents, and healthcare providers in the development of a new resource meant to motivate teenage heart-transplant-patients to take interest and ownership of their long-term health. METHODS: …
This project aimed to creatively bridge this gap-including teenage patients, their parents, and healthcare providers in the development of a …
Clinical outcomes of children receiving ABO-incompatible versus ABO-compatible heart transplantation: a multicentre cohort study.
Urschel S, Ballweg JA, Cantor RS, Koehl DA, Reinhardt Z, Zuckerman WA, Dipchand AI, Kanter KR, Sparks J, McCoy M, Kirklin JK, Carlo WF. Urschel S, et al. Lancet Child Adolesc Health. 2021 May;5(5):341-349. doi: 10.1016/S2352-4642(21)00023-7. Epub 2021 Mar 18. Lancet Child Adolesc Health. 2021. PMID: 33743201
Previous smaller studies suggest similar outcomes to ABO-compatible heart transplantation, but persisting alterations of the immune system in ABO-incompatible recipients might increase the risk of some infections or benefit the graft owing to reduced HLA reactivity. We aimed to a …
Previous smaller studies suggest similar outcomes to ABO-compatible heart transplantation, but persisting alterations of the immune system i …
Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.
López-Abente J, Martínez-Bonet M, Bernaldo-de-Quirós E, Camino M, Gil N, Panadero E, Gil-Jaurena JM, Clemente M, Urschel S, West L, Pion M, Correa-Rocha R. López-Abente J, et al. Among authors: urschel s. Sci Rep. 2021 Jan 12;11(1):827. doi: 10.1038/s41598-020-80567-9. Sci Rep. 2021. PMID: 33436905 Free PMC article.
Post-operative fluid overload as a predictor of hospital and long-term outcomes in a pediatric heart transplant population.
Anderson NM, Bond GY, Joffe AR, MacDonald C, Robertson C, Urschel S, Morgan CJ; Western Canadian Complex Pediatric Therapies Program Follow-up Group. Anderson NM, et al. Among authors: urschel s. Pediatr Transplant. 2021 May;25(3):e13897. doi: 10.1111/petr.13897. Epub 2020 Nov 1. Pediatr Transplant. 2021. PMID: 33131128
Capillary leak and FO are associated with organ injury and may influence both short- and long-term outcomes. This study aimed to 1) determine the extent, timing, and predictors of post-operative FO and 2) investigate the association of FO with clinically important outcomes …
Capillary leak and FO are associated with organ injury and may influence both short- and long-term outcomes. This study aimed to 1) d …
Memory B Cells and Long-lived Plasma Cells.
Ionescu L, Urschel S. Ionescu L, et al. Among authors: urschel s. Transplantation. 2019 May;103(5):890-898. doi: 10.1097/TP.0000000000002594. Transplantation. 2019. PMID: 30747835 Review.
The importance of B cell and antibody-mediated immune response in the acute and long-term persistence of transplanted solid organs has become increasingly evident in recent years. ...Antibodies originate from plasma cells (PCs), which are terminally differentiated B cells. …
The importance of B cell and antibody-mediated immune response in the acute and long-term persistence of transplanted solid organs ha …
ABO-incompatible heart transplantation.
Urschel S, West LJ. Urschel S, et al. Curr Opin Pediatr. 2016 Oct;28(5):613-9. doi: 10.1097/MOP.0000000000000398. Curr Opin Pediatr. 2016. PMID: 27379804 Free PMC article. Review.
Observations of reduced antibody production and B-cell immunity toward the donor blood group have been confirmed in long-term follow-up. Mechanisms contributing to tolerance in this setting involve the interplay between B-cells and the complement system and the development …
Observations of reduced antibody production and B-cell immunity toward the donor blood group have been confirmed in long-term follow- …
Acute kidney injury after heart transplant in young children: risk factors and outcomes.
MacDonald C, Norris C, Alton GY, Urschel S, Joffe AR, Morgan CJ; Western Canadian Complex Pediatric Therapies Follow-Up Group. MacDonald C, et al. Among authors: urschel s. Pediatr Nephrol. 2016 Apr;31(4):671-8. doi: 10.1007/s00467-015-3252-x. Epub 2015 Nov 11. Pediatr Nephrol. 2016. PMID: 26559064
METHODS: Using data from a prospective study of 66 young children, we evaluated: (1) post-operative AKI rate (by pediatric modified RIFLE criteria); (2) pre, intra, and early post-operative AKI risk factors using stepwise logistic regression (3) effect of AKI on short-term …
METHODS: Using data from a prospective study of 66 young children, we evaluated: (1) post-operative AKI rate (by pediatric modified RIFLE cr …
Advanced therapies for congenital heart disease: ventricular assist devices and heart transplantation.
VanderPluym C, Urschel S, Buchholz H. VanderPluym C, et al. Among authors: urschel s. Can J Cardiol. 2013 Jul;29(7):796-802. doi: 10.1016/j.cjca.2013.02.008. Epub 2013 May 16. Can J Cardiol. 2013. PMID: 23683470 Review.
Improvement in pre-, peri-, and postoperative management of congenital heart disease (CHD) has significantly increased long-term survival in children with CHD. However, there is a subset of patients with CHD who are either poor candidates for surgical palliation or in whom …
Improvement in pre-, peri-, and postoperative management of congenital heart disease (CHD) has significantly increased long-term surv …
12 results