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Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors.
Gulej R, Nyúl-Tóth Á, Csik B, Petersen B, Faakye J, Negri S, Chandragiri SS, Mukli P, Yabluchanskiy A, Conley S, Huffman DM, Csiszar A, Tarantini S, Ungvari Z. Gulej R, et al. Among authors: ungvari z. Geroscience. 2024 Feb;46(1):327-347. doi: 10.1007/s11357-023-01039-2. Epub 2023 Dec 21. Geroscience. 2024. PMID: 38123890 Free PMC article.
In conclusion, even a brief exposure to a youthful humoral environment can mitigate neurovascular aging phenotypes, rejuvenating NVC responses. Conversely, short-term exposure to an aged humoral milieu in young mice accelerates the acquisition of neurovascular aging traits …
In conclusion, even a brief exposure to a youthful humoral environment can mitigate neurovascular aging phenotypes, rejuvenating NVC respons …
Whole brain irradiation-induced endothelial dysfunction in the mouse brain.
Kiss T, Ungvari A, Gulej R, Nyúl-Tóth Á, Tarantini S, Benyo Z, Csik B, Yabluchanskiy A, Mukli P, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: ungvari z. Geroscience. 2024 Feb;46(1):531-541. doi: 10.1007/s11357-023-00990-4. Epub 2023 Nov 13. Geroscience. 2024. PMID: 37953375 Free PMC article.
These findings provide additional preclinical evidence supporting the notion that WBI induces dysfunction in cerebrovascular endothelial cells, which in turn likely contributes to the detrimental long-term effects of the treatment. This endothelial dysfunction resembles an …
These findings provide additional preclinical evidence supporting the notion that WBI induces dysfunction in cerebrovascular endothelial cel …
Disruption of Vitamin D Signaling Impairs Adaptation of Cerebrocortical Microcirculation to Carotid Artery Occlusion in Hyperandrogenic Female Mice.
Nagy D, Hricisák L, Walford GP, Lékai Á, Karácsony G, Várbíró S, Ungvári Z, Benyó Z, Pál É. Nagy D, et al. Among authors: ungvari z. Nutrients. 2023 Sep 5;15(18):3869. doi: 10.3390/nu15183869. Nutrients. 2023. PMID: 37764653 Free PMC article.
These findings suggest that the cerebrovascular consequences of disrupted VDR signaling are less pronounced in females, providing a level of protection even after ovariectomy. Conversely, even short-term androgen excess with lacking VDR signaling may lead to unfavorable ou …
These findings suggest that the cerebrovascular consequences of disrupted VDR signaling are less pronounced in females, providing a level of …
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors.
Prodan CI, Batra A, Ungvari Z, Liotta EM. Prodan CI, et al. Among authors: ungvari z. Geroscience. 2022 Jun;44(3):1255-1262. doi: 10.1007/s11357-022-00566-8. Epub 2022 Apr 25. Geroscience. 2022. PMID: 35467316 Free PMC article.
Further study of COVID-19-related public health policies on acute stroke populations is needed to capture the long-term impact of such policies. Learning from the real-time impact of pandemic surges and public health policy on presentation of acute medical conditions, such …
Further study of COVID-19-related public health policies on acute stroke populations is needed to capture the long-term impact of suc …
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults.
Owens CD, Mukli P, Csipo T, Lipecz A, Silva-Palacios F, Dasari TW, Tarantini S, Gardner AW, Montgomery PS, Waldstein SR, Kellawan JM, Nyul-Toth A, Balasubramanian P, Sotonyi P, Csiszar A, Ungvari Z, Yabluchanskiy A. Owens CD, et al. Among authors: ungvari z. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H924-H935. doi: 10.1152/ajpheart.00616.2021. Epub 2022 Mar 25. Am J Physiol Heart Circ Physiol. 2022. PMID: 35333116 Free PMC article.
We found that cognitive performance was compromised in patients with PAD, evidenced by reduced visual memory, short-term memory, and sustained attention. We found that NVC responses and peripheral microvascular endothelial function were significantly impaired in patients w …
We found that cognitive performance was compromised in patients with PAD, evidenced by reduced visual memory, short-term memory, and …
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Kiss T, Nyúl-Tóth Á, Gulej R, Tarantini S, Csipo T, Mukli P, Ungvari A, Balasubramanian P, Yabluchanskiy A, Benyo Z, Conley SM, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: ungvari z. Geroscience. 2022 Apr;44(2):953-981. doi: 10.1007/s11357-022-00519-1. Epub 2022 Feb 5. Geroscience. 2022. PMID: 35124764 Free PMC article.
IPA Upstream Regulator analysis (performed to identify upstream transcriptional regulators that may contribute to the observed transcriptomic changes) suggests that the mechanism of action of pro-geronic factors present in old blood may include inhibition of pathways mediated by …
IPA Upstream Regulator analysis (performed to identify upstream transcriptional regulators that may contribute to the observed transcriptomi …
Cognitive decrement in older adults with symptomatic peripheral artery disease.
Gardner AW, Montgomery PS, Wang M, Shen B, Casanegra AI, Silva-Palacios F, Ungvari Z, Yabluchanskiy A, Csiszar A, Waldstein SR. Gardner AW, et al. Among authors: ungvari z. Geroscience. 2021 Oct;43(5):2455-2465. doi: 10.1007/s11357-021-00437-8. Epub 2021 Sep 9. Geroscience. 2021. PMID: 34498199 Free PMC article.
Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis.
Csipo T, Cassidy BR, Balasubramanian P, Drevets DA, Ungvari ZI, Yabluchanskiy A. Csipo T, et al. Among authors: ungvari zi. Front Aging Neurosci. 2021 May 14;13:644733. doi: 10.3389/fnagi.2021.644733. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34054502 Free PMC article.
Our findings suggest that sepsis-associated endothelial dysfunction and impairment of NVC responses may contribute to long-term cognitive deficits in older sepsis survivors....
Our findings suggest that sepsis-associated endothelial dysfunction and impairment of NVC responses may contribute to long-term cogni …
Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.
Csipo T, Lipecz A, Mukli P, Bahadli D, Abdulhussein O, Owens CD, Tarantini S, Hand RA, Yabluchanska V, Kellawan JM, Sorond F, James JA, Csiszar A, Ungvari ZI, Yabluchanskiy A. Csipo T, et al. Among authors: ungvari zi. PLoS One. 2021 May 19;16(5):e0250043. doi: 10.1371/journal.pone.0250043. eCollection 2021. PLoS One. 2021. PMID: 34010279 Free PMC article.
34 results