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Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
Rheault MN, Alpers CE, Barratt J, Bieler S, Canetta P, Chae DW, Coppock G, Diva U, Gesualdo L, Heerspink HJL, Inrig JK, Kirsztajn GM, Kohan D, Komers R, Kooienga LA, Lieberman K, Mercer A, Noronha IL, Perkovic V, Radhakrishnan J, Rote W, Rovin B, Tesar V, Trimarchi H, Tumlin J, Wong MG, Trachtman H; DUPRO Steering Committee and DUPLEX Investigators. Rheault MN, et al. N Engl J Med. 2023 Dec 28;389(26):2436-2445. doi: 10.1056/NEJMoa2308550. Epub 2023 Nov 3. N Engl J Med. 2023. PMID: 37921461 Clinical Trial.
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment with sparsentan for FSGS are unknown. METHODS: In this phase 3 trial, we enrolled patient …
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The e …
Health disparities in COVID-19: immune and vascular changes are linked to disease severity and persist in a high-risk population in Riverside County, California.
Bergersen KV, Pham K, Li J, Ulrich MT, Merrill P, He Y, Alaama S, Qiu X, Harahap-Carrillo IS, Ichii K, Frost S, Kaul M, Godzik A, Heinrich EC, Nair MG. Bergersen KV, et al. Among authors: ulrich mt. BMC Public Health. 2023 Aug 19;23(1):1584. doi: 10.1186/s12889-023-16462-5. BMC Public Health. 2023. PMID: 37598150 Free PMC article.
The goal of this study was to identify immune and endothelial factors that are associated with COVID-19 outcomes in Riverside County, a high-risk and predominantly Hispanic community, and investigate the long-term impacts of COVID-19 infection. METHODS: 112 participants in …
The goal of this study was to identify immune and endothelial factors that are associated with COVID-19 outcomes in Riverside County, a high …
Culturing Limbal Epithelial Cells of Long-term Stored Corneal Donors (Organ Culture) In Vitro - A Stepwise Linear Regression Algorithm.
Li Z, Böhringer D, Stachon T, Nastaranpour M, Fries FN, Seitz B, Ulrich M, Munteanu C, Langenbucher A, Szentmáry N. Li Z, et al. Among authors: ulrich m. Klin Monbl Augenheilkd. 2023 Oct 19. doi: 10.1055/a-2084-7168. Online ahead of print. Klin Monbl Augenheilkd. 2023. PMID: 37130569 English.
PURPOSE: To assess various potential factors on human limbal epithelial cell (LEC) outgrowth in vitro using corneal donor tissue following long-term storage (organ culture) and a stepwise linear regression algorithm. ...
PURPOSE: To assess various potential factors on human limbal epithelial cell (LEC) outgrowth in vitro using corneal donor tissue following l …
[Pandemic and value change?].
Eder A, Aschauer W, Höllinger F, Ulrich M. Eder A, et al. Among authors: ulrich m. OZS Osterr Z Soziol. 2022;47(4):333-357. doi: 10.1007/s11614-022-00505-z. Epub 2022 Oct 14. OZS Osterr Z Soziol. 2022. PMID: 36258896 Free PMC article. German.
Recent sociological diagnoses suggest that profound social crises such as the COVID-19 pandemic challenge our value orientations and could change them even in the relatively short term. Based on this observation, we investigate whether significant shifts in value prioritie …
Recent sociological diagnoses suggest that profound social crises such as the COVID-19 pandemic challenge our value orientations and could c …
Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.
Halliday A, Bulbulia R, Bonati LH, Chester J, Cradduck-Bamford A, Peto R, Pan H; ACST-2 Collaborative Group. Halliday A, et al. Lancet. 2021 Sep 18;398(10305):1065-1073. doi: 10.1016/S0140-6736(21)01910-3. Epub 2021 Aug 29. Lancet. 2021. PMID: 34469763 Free PMC article. Clinical Trial.
Comparison of their long-term protective effects requires large-scale randomised evidence. ...INTERPRETATION: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disab …
Comparison of their long-term protective effects requires large-scale randomised evidence. ...INTERPRETATION: Serious complications a …
Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles.
Mulder PPG, Vlig M, Boekema BKHL, Stoop MM, Pijpe A, van Zuijlen PPM, de Jong E, van Cranenbroek B, Joosten I, Koenen HJPM, Ulrich MMW. Mulder PPG, et al. Among authors: ulrich mmw. Front Immunol. 2021 Jan 29;11:621222. doi: 10.3389/fimmu.2020.621222. eCollection 2020. Front Immunol. 2021. PMID: 33584717 Free PMC article.
Severe burn injury causes local and systemic immune responses that can persist up to months, and can lead to systemic inflammatory response syndrome, organ damage and long-term sequalae such as hypertrophic scarring. To prevent these pathological conditions, a better under …
Severe burn injury causes local and systemic immune responses that can persist up to months, and can lead to systemic inflammatory response …
Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways.
Zissler UM, Jakwerth CA, Guerth F, Lewitan L, Rothkirch S, Davidovic M, Ulrich M, Oelsner M, Garn H, Schmidt-Weber CB, Chaker AM. Zissler UM, et al. Among authors: ulrich m. Allergy. 2021 Aug;76(8):2461-2474. doi: 10.1111/all.14756. Epub 2021 Mar 6. Allergy. 2021. PMID: 33528894
CONCLUSIONS: Allergen-specific immunotherapy induces a yet unknown local gene expression footprint in the lower airways that on one hand appears to be a result of multiple regulatory pathways and on the other hand reveals SCGB1A1 as novel anti-inflammatory mediator of long-ter …
CONCLUSIONS: Allergen-specific immunotherapy induces a yet unknown local gene expression footprint in the lower airways that on one hand app …
Organ Transplantation in Hereditary Fibrinogen A α-Chain Amyloidosis: A Case Series of French Patients.
Meyer L, Ulrich M, Ducloux D, Garrigue V, Vigneau C, Nochy D, Bobrie G, Ferlicot S, Colombat M, Boffa JJ, Clabault K, Mansour J, Mousson C, Azar R, Bacri JL, Dürrbach A, Duvic C, El Karoui K, Hoffmann M, Lionet A, Panescu V, Plaisier E, Ratsimbazafy A, Guerrot D, Vrigneaud L, Valleix S, François H. Meyer L, et al. Among authors: ulrich m. Am J Kidney Dis. 2020 Sep;76(3):384-391. doi: 10.1053/j.ajkd.2020.02.445. Epub 2020 Jul 10. Am J Kidney Dis. 2020. PMID: 32660897
The aim of this study was to characterize the natural history and long-term outcomes of this disease, with and without organ transplantation, among patients with AFib amyloidosis and various FGA variants. ...
The aim of this study was to characterize the natural history and long-term outcomes of this disease, with and without organ transpla …
C1 Inhibitor Administration Reduces Local Inflammation and Capillary Leakage, Without Affecting Long-term Wound Healing Parameters, in a Pig Burn Wound Model.
Korkmaz HI, Ulrich MMW, Wieringen WNV, Doǧan H, Vlig M, Emmens RW, Meyer KW, Sinnige P, Zeerleder S, Wouters D, Ham MSV, Zuijlen PPMV, Krijnen PAJ, Niessen HWM. Korkmaz HI, et al. Among authors: ulrich mmw. Antiinflamm Antiallergy Agents Med Chem. 2021;20(2):150-160. doi: 10.2174/1871523019666200702101513. Antiinflamm Antiallergy Agents Med Chem. 2021. PMID: 32614753
Despite these effects, no significant differences in the long-term wound healing parameters necrosis, reepithelialization and wound contraction were observed between C1inh and control pigs. CONCLUSION: In pigs, 15 days of C1inh treatment after burn, leads to a reduction in …
Despite these effects, no significant differences in the long-term wound healing parameters necrosis, reepithelialization and wound c …
Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity.
Patrono LV, Pléh K, Samuni L, Ulrich M, Röthemeier C, Sachse A, Muschter S, Nitsche A, Couacy-Hymann E, Boesch C, Wittig RM, Calvignac-Spencer S, Leendertz FH. Patrono LV, et al. Among authors: ulrich m. Nat Microbiol. 2020 Jul;5(7):955-965. doi: 10.1038/s41564-020-0706-0. Epub 2020 Apr 27. Nat Microbiol. 2020. PMID: 32341480
We also show that the carnivorous component of the Tai chimpanzees' diet, mainly consisting of the sympatric monkeys they regularly hunt, did not change nor shift towards rodent consumption (the presumed reservoir) before the outbreaks, suggesting that the sudden emergence of mon …
We also show that the carnivorous component of the Tai chimpanzees' diet, mainly consisting of the sympatric monkeys they regularly hunt, di …
32 results