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2012 3
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Page 1
The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.
van Leeuwen EM, Smouter FA, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, Bis JC, White CC, Jaiswal A, Oostra BA, Hofman A, Rivadeneira F, Uitterlinden AG, Boerwinkle E, Ballantyne CM, Gudnason V, Psaty BM, Cupples LA, Järvelin MR, Ripatti S, Isaacs A, Müller-Myhsok B, Karssen LC, van Duijn CM. van Leeuwen EM, et al. PLoS One. 2014 Oct 20;9(10):e109290. doi: 10.1371/journal.pone.0109290. eCollection 2014. PLoS One. 2014. PMID: 25329471 Free PMC article.
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction terms with a p-value<1 . 10-8 that replicated in the two independent cohorts. We were not able to replicate any of these interaction ter …
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction te …
Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine.
Wyatt CM, Kitch D, Gupta SK, Tierney C, Daar ES, Sax PE, Ha B, Melbourne K, McComsey GA; AIDS Clinical Trials Group Study A5224s Team. Wyatt CM, et al. J Acquir Immune Defic Syndr. 2014 Sep 1;67(1):36-44. doi: 10.1097/QAI.0000000000000245. J Acquir Immune Defic Syndr. 2014. PMID: 25117929 Free PMC article. Clinical Trial.
These are the first data from a randomized trial to suggest that initiation of TDF/FTC may not be associated with the same degree of improvement in proteinuria and albuminuria that have been reported with other regimens. Future studies should consider the long-term clinica …
These are the first data from a randomized trial to suggest that initiation of TDF/FTC may not be associated with the same degree of improve …
Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats.
Hokugo A, Sun S, Park S, McKenna CE, Nishimura I. Hokugo A, et al. Bone. 2013 Mar;53(1):59-68. doi: 10.1016/j.bone.2012.11.030. Epub 2012 Dec 4. Bone. 2013. PMID: 23219943 Free PMC article.
Our results suggest that equilibrium-dependent BP-bone interaction may, in part, determine the effectiveness and influence side effects of long-term and repeated applications of BPs....
Our results suggest that equilibrium-dependent BP-bone interaction may, in part, determine the effectiveness and influence side effects of l …
Integrity of the blood-testis barrier in healthy men after suppression of spermatogenesis with testosterone and levonorgestrel.
Ilani N, Armanious N, Lue YH, Swerdloff RS, Baravarian S, Adler A, Tsang C, Jia Y, Cui YG, Wang XH, Zhou ZM, Sha JH, Wang C. Ilani N, et al. Hum Reprod. 2012 Dec;27(12):3403-11. doi: 10.1093/humrep/des340. Epub 2012 Sep 27. Hum Reprod. 2012. PMID: 23019303 Free PMC article. Clinical Trial.
LIMITATIONS/REASONS FOR CAUTION: The duration of the study was short and the long-term effects of male hormonal contraceptive treatments on the integrity of the blood-testis barrier remain to be determined. ...
LIMITATIONS/REASONS FOR CAUTION: The duration of the study was short and the long-term effects of male hormonal contraceptive treatme …
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. Rosen CJ, et al. Endocr Rev. 2012 Jun;33(3):456-92. doi: 10.1210/er.2012-1000. Epub 2012 May 17. Endocr Rev. 2012. PMID: 22596255 Free PMC article. Review.
Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more stu …
Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, a …