The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.
van Leeuwen EM, Smouter FA, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, Bis JC, White CC, Jaiswal A, Oostra BA, Hofman A, Rivadeneira F, Uitterlinden AG, Boerwinkle E, Ballantyne CM, Gudnason V, Psaty BM, Cupples LA, Järvelin MR, Ripatti S, Isaacs A, Müller-Myhsok B, Karssen LC, van Duijn CM.
van Leeuwen EM, et al.
PLoS One. 2014 Oct 20;9(10):e109290. doi: 10.1371/journal.pone.0109290. eCollection 2014.
PLoS One. 2014.
PMID: 25329471
Free PMC article.
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction terms with a p-value<1 . 10-8 that replicated in the two independent cohorts. We were not able to replicate any of these interaction ter …
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction te …