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2011 3
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23 results

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High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex.
Hussain SA, Schmid E, Peters JM, Goyal M, Bebin EM, Northrup H, Sahin M, Krueger DA, Wu JY; Tuberous Sclerosis Complex Autism Center of Excellence Network. Hussain SA, et al. Epilepsy Res. 2018 Dec;148:1-7. doi: 10.1016/j.eplepsyres.2018.09.016. Epub 2018 Oct 2. Epilepsy Res. 2018. PMID: 30296632 Free PMC article.
After initially successful treatment of infantile spasms, the long-term cumulative risk of relapse approaches 50%, and there is no established protocol to mitigate this risk. ...
After initially successful treatment of infantile spasms, the long-term cumulative risk of relapse approaches 50%, and there is no es …
A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses.
Daum RS, Miller LG, Immergluck L, Fritz S, Creech CB, Young D, Kumar N, Downing M, Pettibone S, Hoagland R, Eells SJ, Boyle MG, Parker TC, Chambers HF; DMID 07-0051 Team. Daum RS, et al. N Engl J Med. 2017 Jun 29;376(26):2545-2555. doi: 10.1056/NEJMoa1607033. N Engl J Med. 2017. PMID: 28657870 Free PMC article. Clinical Trial.
CONCLUSIONS: As compared with incision and drainage alone, clindamycin or TMP-SMX in conjunction with incision and drainage improves short-term outcomes in patients who have a simple abscess. This benefit must be weighed against the known side-effect profile of these antim …
CONCLUSIONS: As compared with incision and drainage alone, clindamycin or TMP-SMX in conjunction with incision and drainage improves short- …
Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine.
Nelson MD, Sharif B, Shaw JL, Cook-Wiens G, Wei J, Shufelt C, Mehta PK, Thomson LEJ, Berman DS, Thompson RB, Handberg EM, Pepine CJ, Li D, Bairey Merz CN. Nelson MD, et al. Clin Cardiol. 2017 May;40(5):300-306. doi: 10.1002/clc.22660. Epub 2016 Dec 22. Clin Cardiol. 2017. PMID: 28004395 Free PMC article.
METHODS: To test this hypothesis, we performed retrospective tissue tracking analysis to evaluate systolic/diastolic strain, using cardiac magnetic resonance imaging cine images acquired in a recently completed, randomized, double-blind, placebo-controlled, crossover trial of sho …
METHODS: To test this hypothesis, we performed retrospective tissue tracking analysis to evaluate systolic/diastolic strain, using cardiac m …
A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve.
Bairey Merz CN, Handberg EM, Shufelt CL, Mehta PK, Minissian MB, Wei J, Thomson LE, Berman DS, Shaw LJ, Petersen JW, Brown GH, Anderson RD, Shuster JJ, Cook-Wiens G, Rogatko A, Pepine CJ. Bairey Merz CN, et al. Eur Heart J. 2016 May 14;37(19):1504-13. doi: 10.1093/eurheartj/ehv647. Epub 2015 Nov 27. Eur Heart J. 2016. PMID: 26614823 Free PMC article. Clinical Trial.
MATERIALS AND RESULTS: Randomized, double-blind, placebo-controlled, crossover, mechanistic trial in subjects with evidence of CMD [invasive coronary reactivity testing or non-invasive cardiac magnetic resonance imaging myocardial perfusion reserve index (MPRI)]. Short-term
MATERIALS AND RESULTS: Randomized, double-blind, placebo-controlled, crossover, mechanistic trial in subjects with evidence of CMD [invasive …
Association of Triple Therapy With Improvement in Cholesterol Profiles Over Two-Year Followup in the Treatment of Early Aggressive Rheumatoid Arthritis Trial.
Charles-Schoeman C, Wang X, Lee YY, Shahbazian A, Navarro-Millán I, Yang S, Chen L, Cofield SS, Moreland LW, O'Dell J, Bathon JM, Paulus H, Bridges SL Jr, Curtis JR. Charles-Schoeman C, et al. Arthritis Rheumatol. 2016 Mar;68(3):577-86. doi: 10.1002/art.39502. Arthritis Rheumatol. 2016. PMID: 26606398 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate long-term changes in cholesterol levels in patients with early rheumatoid arthritis (RA) who were randomized to begin treatment with methotrexate (MTX) monotherapy, MTX plus etanercept, or triple therapy (MTX plus sulfasalazine plus hydroxychloroquin …
OBJECTIVE: To evaluate long-term changes in cholesterol levels in patients with early rheumatoid arthritis (RA) who were randomized t …
Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial.
Black DS, O'Reilly GA, Olmstead R, Breen EC, Irwin MR. Black DS, et al. JAMA Intern Med. 2015 Apr;175(4):494-501. doi: 10.1001/jamainternmed.2014.8081. JAMA Intern Med. 2015. PMID: 25686304 Free PMC article. Clinical Trial.
Formalized mindfulness-based interventions have clinical importance by possibly serving to remediate sleep problems among older adults in the short term, and this effect appears to carry over into reducing sleep-related daytime impairment that has implications for quality …
Formalized mindfulness-based interventions have clinical importance by possibly serving to remediate sleep problems among older adults in th …
Evaluating model-based imputation methods for missing covariates in regression models with interactions.
Kim S, Sugar CA, Belin TR. Kim S, et al. Stat Med. 2015 May 20;34(11):1876-88. doi: 10.1002/sim.6435. Epub 2015 Jan 29. Stat Med. 2015. PMID: 25630757 Free PMC article.
We derive the conditional distribution of the missing covariate and interaction term given the observed covariate and the outcome variable, and examine the performance of a multiple imputation procedure based on this distribution. ...Just as importantly for general practit …
We derive the conditional distribution of the missing covariate and interaction term given the observed covariate and the outcome var …
The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.
van Leeuwen EM, Smouter FA, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, Bis JC, White CC, Jaiswal A, Oostra BA, Hofman A, Rivadeneira F, Uitterlinden AG, Boerwinkle E, Ballantyne CM, Gudnason V, Psaty BM, Cupples LA, Järvelin MR, Ripatti S, Isaacs A, Müller-Myhsok B, Karssen LC, van Duijn CM. van Leeuwen EM, et al. PLoS One. 2014 Oct 20;9(10):e109290. doi: 10.1371/journal.pone.0109290. eCollection 2014. PLoS One. 2014. PMID: 25329471 Free PMC article.
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction terms with a p-value<1 . 10-8 that replicated in the two independent cohorts. We were not able to replicate any of these interaction ter
By performing a meta-analysis together with Rotterdam Study cohorts II and III (RS-II and RS-III), we were able to filter 181 interaction te …
Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine.
Wyatt CM, Kitch D, Gupta SK, Tierney C, Daar ES, Sax PE, Ha B, Melbourne K, McComsey GA; AIDS Clinical Trials Group Study A5224s Team. Wyatt CM, et al. J Acquir Immune Defic Syndr. 2014 Sep 1;67(1):36-44. doi: 10.1097/QAI.0000000000000245. J Acquir Immune Defic Syndr. 2014. PMID: 25117929 Free PMC article. Clinical Trial.
These are the first data from a randomized trial to suggest that initiation of TDF/FTC may not be associated with the same degree of improvement in proteinuria and albuminuria that have been reported with other regimens. Future studies should consider the long-term clinica …
These are the first data from a randomized trial to suggest that initiation of TDF/FTC may not be associated with the same degree of improve …
Lack of FGF23 response to acute changes in serum calcium and PTH in humans.
Wesseling-Perry K, Wang H, Elashoff R, Gales B, Jüppner H, Salusky IB. Wesseling-Perry K, et al. J Clin Endocrinol Metab. 2014 Oct;99(10):E1951-6. doi: 10.1210/jc.2014-2125. Epub 2014 Jul 25. J Clin Endocrinol Metab. 2014. PMID: 25062462 Free PMC article. Clinical Trial.
CONTEXT: 1,25-Dihydroxyvitamin D (1,25D) administration and long-term increases in phosphate, PTH, and calcium concentrations are associated with increases in circulating fibroblast growth factor 23 (FGF23); however, whether or not acute changes in serum calcium modulate s …
CONTEXT: 1,25-Dihydroxyvitamin D (1,25D) administration and long-term increases in phosphate, PTH, and calcium concentrations are ass …
23 results