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2008 5
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High prevalence of normal tests assessing hypercortisolism in subjects with mild and episodic Cushing's syndrome suggests that the paradigm for diagnosis and exclusion of Cushing's syndrome requires multiple testing.
Friedman TC, Ghods DE, Shahinian HK, Zachery L, Shayesteh N, Seasholtz S, Zuckerbraun E, Lee ML, McCutcheon IE. Friedman TC, et al. Horm Metab Res. 2010 Nov;42(12):874-81. doi: 10.1055/s-0030-1263128. Epub 2010 Aug 27. Horm Metab Res. 2010. PMID: 20803415 Free PMC article.
Rather, the paradigm for the diagnosis should be a careful history and physical examination and in those patients in whom mild Cushing's syndrome/disease is strongly suspected, multiple tests assessing hypercortisolism should be performed on subsequent occasions, especially when …
Rather, the paradigm for the diagnosis should be a careful history and physical examination and in those patients in whom mild Cushing's syn …
Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.
Anghel A, Jamieson CA, Ren X, Young J, Porche R, Ozigbo E, Ghods DE, Lee ML, Liu Y, Lutfy K, Friedman TC. Anghel A, et al. Neuroscience. 2010 May 5;167(2):554-66. doi: 10.1016/j.neuroscience.2010.01.043. Epub 2010 Feb 6. Neuroscience. 2010. PMID: 20144693 Free PMC article.
Long-term morphine treatment up-regulated 35 genes and down-regulated 51 genes. ...Long-term morphine treatment up-regulated 85 genes and down-regulated 37 pituitary genes. ...
Long-term morphine treatment up-regulated 35 genes and down-regulated 51 genes. ...Long-term morphine treatment up-regulated 8 …
The effects of opioids and opioid analogs on animal and human endocrine systems.
Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. Vuong C, et al. Endocr Rev. 2010 Feb;31(1):98-132. doi: 10.1210/er.2009-0009. Epub 2009 Nov 10. Endocr Rev. 2010. PMID: 19903933 Free PMC article. Review.
Physicians are also increasingly administering opioid analgesics for noncancer chronic pain. Thus, knowledge of the long-term consequences of opioid use/abuse has important implications for fully evaluating the clinical usefulness of opioid medications. ...
Physicians are also increasingly administering opioid analgesics for noncancer chronic pain. Thus, knowledge of the long-term consequ …
The impact of public hospital closure on medical and residency education: implications and recommendations.
Walker KO, Calmes D, Hanna N, Baker R. Walker KO, et al. J Natl Med Assoc. 2008 Dec;100(12):1377-83. doi: 10.1016/s0027-9684(15)31537-6. J Natl Med Assoc. 2008. PMID: 19110905 Free PMC article.
CONCLUSION: While the medical educational program changes undertaken in the wake of hospital closure have negatively affected the immediate clinical educational experiences of medical students and residents, it remains to be seen whether the training site location changes will al …
CONCLUSION: While the medical educational program changes undertaken in the wake of hospital closure have negatively affected the immediate …
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction.
Espinosa VP, Liu Y, Ferrini M, Anghel A, Nie Y, Tripathi PV, Porche R, Jansen E, Stuart RC, Nillni EA, Lutfy K, Friedman TC. Espinosa VP, et al. Neuroscience. 2008 Oct 15;156(3):788-99. doi: 10.1016/j.neuroscience.2008.07.063. Epub 2008 Aug 9. Neuroscience. 2008. PMID: 18771713 Free PMC article.
While short-term morphine exposure down-regulated, long-term morphine exposure up-regulated P-CREB, PC1/3 and PC2 protein levels in the rat hypothalamus as determined by Western blot analysis. ...Our data suggest that the regulation of the prohormone processing syst …
While short-term morphine exposure down-regulated, long-term morphine exposure up-regulated P-CREB, PC1/3 and PC2 protein leve …
The role of translational research in addressing health disparities: a conceptual framework.
Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. Fleming ES, et al. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-155-60. Ethn Dis. 2008. PMID: 18646340 Free PMC article.
Translational research has tremendous potential as a tool to reduce health disparities in the United States, but a lack of common understanding about the scope of this dynamic, multidisciplinary approach to research has limited its use. The term "translational research" is …
Translational research has tremendous potential as a tool to reduce health disparities in the United States, but a lack of common understand …
Oral opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women.
Fraser LA, Morrison D, Morley-Forster P, Paul TL, Tokmakejian S, Larry Nicholson R, Bureau Y, Friedman TC, Van Uum SH. Fraser LA, et al. Exp Clin Endocrinol Diabetes. 2009 Jan;117(1):38-43. doi: 10.1055/s-2008-1076715. Epub 2008 Jun 3. Exp Clin Endocrinol Diabetes. 2009. PMID: 18523930 Free PMC article.
The objective of this cross-sectional study was to determine the effect of long-term oral opioids on gonadal status and BMD in male and female patients with chronic non-cancer pain (CNCP). ...
The objective of this cross-sectional study was to determine the effect of long-term oral opioids on gonadal status and BMD in male a …
Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels.
Yuen KC, Cook DM, Sahasranam P, Patel P, Ghods DE, Shahinian HK, Friedman TC. Yuen KC, et al. Clin Endocrinol (Oxf). 2008 Aug;69(2):292-8. doi: 10.1111/j.1365-2265.2008.03201.x. Epub 2008 Jan 25. Clin Endocrinol (Oxf). 2008. PMID: 18221393 Free PMC article.
CONCLUSIONS: Our data demonstrated that a substantial number of patients with nonsecreting pituitary microadenomas failed the GHRH-arginine test despite normal serum IGF-1 levels, and had at least one other pituitary hormone deficiency, suggesting that nonsecreting microadenomas …
CONCLUSIONS: Our data demonstrated that a substantial number of patients with nonsecreting pituitary microadenomas failed the GHRH-arginine …